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Peer-reviewedCC BYMicroPublication biology

TBC-2, a Rab GTPase activating protein, regulates the localization of the HLH-30/TFEB and PQM-1 transcription factors in the C. elegans intestine.

  • Soumyendu Saha1
  • Icten Meras1
  • Christian E Rocheleau2,3,1
  1. 1Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada.
  2. 2Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, QC, Canada.
  3. 3Metabolic Disorders and Complications Program, RI-MUHC, Montreal, QC, CA.
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Abstract

Insulin/IGF signaling (IIS) inhibits the nuclear localization of the DAF-16 /FOXO transcription factor to regulate longevity and stress resistance in C. elegans . In the intestine, IIS promotes DAF-16 localization to endosomes and loss of TBC-2 , a RAB-5 GAP, results in increased endomembrane localization of DAF-16 at the expense of nuclear localization, decreased DAF-16 target gene expression, longevity and stress resistance. Here we found that TBC-2 differentially regulates the localization of the IIS-regulated transcription factors PQM-1 and HLH-30 /TFEB. Our results suggest a broader role for TBC-2 in regulating IIS and that TBC-2 likely functions at an upstream point in the IIS pathway.

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Cite

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BibTeX
@article{saha2026tbc2,
  title = {{TBC-2, a Rab GTPase activating protein, regulates the localization of the HLH-30/TFEB and PQM-1 transcription factors in the C. elegans intestine.}},
  author = {Soumyendu Saha and Icten Meras and Christian E Rocheleau},
  journal = {MicroPublication biology},
  year = {2026},
  month = oct,
  doi = {10.17912/micropub.biology.002470},
  url = {https://europepmc.org/article/MED/42953546},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - TBC-2, a Rab GTPase activating protein, regulates the localization of the HLH-30/TFEB and PQM-1 transcription factors in the C. elegans intestine.
AU  - Soumyendu Saha
AU  - Icten Meras
AU  - Christian E Rocheleau
PY  - 2026
DA  - 2026/10/13
JO  - MicroPublication biology
DO  - 10.17912/micropub.biology.002470
UR  - https://europepmc.org/article/MED/42953546
AB  - Insulin/IGF signaling (IIS) inhibits the nuclear localization of the DAF-16 /FOXO transcription factor to regulate longevity and stress resistance in C. elegans . In the intestine, IIS promotes DAF-16 localization to endosomes and loss of TBC-2 , a RAB-5 GAP, results in increased endomembrane localization of DAF-16 at the expense of nuclear localization, decreased DAF-16 target gene expression, longevity and stress resistance. Here we found that TBC-2 differentially regulates the localization of the IIS-regulated transcription factors PQM-1 and HLH-30 /TFEB. Our results suggest a broader role for TBC-2 in regulating IIS and that TBC-2 likely functions at an upstream point in the IIS pathway.
SN  - 2578-9430
ER  -