Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 24 min ago
Peer-reviewedCC BYJournal of veterinary science

Phylodynamic analysis provides insights into genotype displacement of duck hepatitis A virus in China.

  • Chenyi Xie1,2
  • Baoyan Wang1
  • Ying Wang1
  • Guangrong Zhao1
  • Yang Liu1,2
  • Jianlong Zhang1,2
  • Xin Yu1
  • Linlin Jiang1,2
  • Jiayu Yu1
  • Jiuyu Zhan1,3
  • Hongwei Zhu1,4
  • Xingxiao Zhang1,5
5 affiliations
  1. 1School of Life Sciences, Ludong University, Yantai 264025, China.
  2. 2Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264025, China.
  3. 3Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264025, China. [email protected].
  4. 4Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264025, China. [email protected].
  5. 5Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264025, China. [email protected].
Read full textPDFDOICite

Abstract

Importance

Duck viral hepatitis, caused by the duck hepatitis A virus (DHAV), poses a significant threat to the global duck industry, particularly in China.Objective

This study examined the evolutionary mechanisms driving the genotype displacement of DHAV-1 by DHAV-3 in China using phylodynamic analysis.Methods

The vp1 genes of 9 DHAV-1 and 17 DHAV-3 strains were sequenced and combined with 82 DHAV-1 and 86 DHAV-3 sequences from GenBank. Bayesian phylogenetic, demographic, and phylogeographic analyses were performed using BEAST v1.10.Results

The substitution rate for DHAV-1 vp1 was 4.89 × 10⁻⁴ substitutions/site/year (95% highest posterior density [HPD]: 3.072 × 10⁻⁴ to 6.83 × 10⁻⁴), and for DHAV-3 was 2.125 × 10⁻⁴ substitutions/site/year (95% HPD: 1.686 × 10⁻⁴ to 2.567 × 10⁻⁴). The time to the most recent common ancestor for DHAV-1 was estimated at ~1911 and for DHAV-3 at ~1992. The demographic trends showed a decline in DHAV-1 after 2003 and a resurgence of DHAV-3 in ~2010. Phylogeography identified China as the hub for DHAV-3 spread to South Korea, Vietnam, and Egypt.Conclusions and relevance

DHAV-3 has a higher evolutionary rate, and adaptive mutations drive its dominance, informing vaccine design and control strategies.

Related

  1. Genotype-by-sequencing of global hyacinth bean (Lablab purpureus) collections provides genomic resources for crop conservation and improvement
    Elice Godson Lekasio, Kelvin Mtei, Xavier Argout +6
    Genetic Resources and Crop EvolutionPeer-reviewedCC BY 4.0Full textPlant biologyHAL
  2. A dual recombinant strategy to quantify PreS1 antibody in hepatitis B patients with genotype B or C virus by ELISA
    Yumin Li, Xiaoyu Wen, Jing Zhan +8
    iSciencePeer-reviewedCC BY-NC-ND 4.0Full textImmunologyMicrobiologyCell PressCrossrefEurope PMC
  3. Near-gapless genome of Sassafras tzumu provides insights into magnoliid evolution and cellulose synthase expansion associated with wood formation
    Xianyin Ding, Zhuchou Lu, Yue Zhang +2
    Horticulture researchPeer-reviewedCC BYFull textPlant biologyEurope PMCPMC
  4. An Early Jurassic soft eggshell provides insights into the evolutionary history of dinosaur eggs
    Zhiyong Di, Haiquan Wang, Tao Wang +6
    Nature CommunicationsPeer-reviewedCC BY-NC-ND 4.0Full textEvolutionary biologyCrossref
  5. A Draft Genome Assembly of Argania spinosa Provides Insights into Lipid Metabolism-Associated Genes and Repeat-Rich Genome Architecture
    My Abdelmajid Kassem, Naoufal Lakhssassi, Dounya Knizia +2
    Plants (Basel, Switzerland)Peer-reviewedCC BYFull textPlant biologyEurope PMC

Cite

BibTeXRIS
BibTeX
@article{xie2026phylodynamic,
  title = {{Phylodynamic analysis provides insights into genotype displacement of duck hepatitis A virus in China.}},
  author = {Chenyi Xie and Baoyan Wang and Ying Wang and Guangrong Zhao and Yang Liu and Jianlong Zhang and Xin Yu and Linlin Jiang and Jiayu Yu and Jiuyu Zhan and Hongwei Zhu and Xingxiao Zhang},
  journal = {Journal of veterinary science},
  year = {2026},
  month = sep,
  doi = {10.4142/jvs.25210},
  url = {https://europepmc.org/article/MED/42847794},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Phylodynamic analysis provides insights into genotype displacement of duck hepatitis A virus in China.
AU  - Chenyi Xie
AU  - Baoyan Wang
AU  - Ying Wang
AU  - Guangrong Zhao
AU  - Yang Liu
AU  - Jianlong Zhang
AU  - Xin Yu
AU  - Linlin Jiang
AU  - Jiayu Yu
AU  - Jiuyu Zhan
AU  - Hongwei Zhu
AU  - Xingxiao Zhang
PY  - 2026
DA  - 2026/09/01
JO  - Journal of veterinary science
DO  - 10.4142/jvs.25210
UR  - https://europepmc.org/article/MED/42847794
AB  - Importance  Duck viral hepatitis, caused by the duck hepatitis A virus (DHAV), poses a significant threat to the global duck industry, particularly in China.Objective  This study examined the evolutionary mechanisms driving the genotype displacement of DHAV-1 by DHAV-3 in China using phylodynamic analysis.Methods  The vp1 genes of 9 DHAV-1 and 17 DHAV-3 strains were sequenced and combined with 82 DHAV-1 and 86 DHAV-3 sequences from GenBank. Bayesian phylogenetic, demographic, and phylogeographic analyses were performed using BEAST v1.10.Results  The substitution rate for DHAV-1 vp1 was 4.89 × 10⁻⁴ substitutions/site/year (95% highest posterior density [HPD]: 3.072 × 10⁻⁴ to 6.83 × 10⁻⁴), and for DHAV-3 was 2.125 × 10⁻⁴ substitutions/site/year (95% HPD: 1.686 × 10⁻⁴ to 2.567 × 10⁻⁴). The time to the most recent common ancestor for DHAV-1 was estimated at ~1911 and for DHAV-3 at ~1992. The demographic trends showed a decline in DHAV-1 after 2003 and a resurgence of DHAV-3 in ~2010. Phylogeography identified China as the hub for DHAV-3 spread to South Korea, Vietnam, and Egypt.Conclusions and relevance  DHAV-3 has a higher evolutionary rate, and adaptive mutations drive its dominance, informing vaccine design and control strategies.
SN  - 1229-845X
SN  - 1976-555X
ER  -