Correlation of Glomerular MBL Deposition with the Clinicopathology and Prognosis of Idiopathic Membranous Nephropathy: A PLA2R Subgroup Analysis.
- 1Department of Nephrology, First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, People's Republic of China.
Abstract
Background and objective
This study investigates the correlation between mannose-binding lectin(MBL)and autoantibody IgG4 against the phospholipase A2 receptor (PLA2R) in idiopathic membranous nephropathy(IMN), as well as the role of MBL in the pathogenesis, clinicopathology, and prognosis of IMN.Methods
Thirty-nine patients with IMN from our hospital between 2021 and 2022 were divided into positive and negative groups based on glomerular MBL immunofluorescence results and anti-PLA2R antibody status. Clinical, pathological, and follow-up data were analyzed.Results
Among the 39 patients, the positive rates of glomerular MBL deposition, IgG4 deposition, and serum anti-PLA2R antibodies were 79.5%, 100%, and 66.7%, respectively. There were no significant differences in clinical and pathological features between MBL-positive and-negative groups, but renal tissue IgG4 expression differed (p<0.05). No significant differences in MBL deposition were found among IMN patients grouped by serum PLA2R antibody levels. Renal tissue C1q expression was low (15.38%). Univariate and multivariate Cox regression analyses showed that lower body weight and C3 negativity were independent promoting factors for patient improved prognosis (P<0.05). Kaplan-Meier survival analysis indicated that there were no significant differences in complete remission, partial remission, and relapse between MBL deposition positive and negative patients (P>0.05).Conclusion
Glomerular MBL deposition correlates with renal tissue IgG4 deposition (p=0.03), suggesting participation in IMN pathogenesis via lectin-pathway complement activation. However, no significant difference in MBL deposition was found between patients grouped by serum anti-PLA2R antibody status, nevertheless, its presence or absence exerts no significant impact on clinical presentation, pathology, or prognosis. In the exploratory Cox regression analysis, negative glomerular C3a deposition was associated with a higher likelihood of remission, though this requires validation in larger cohorts.
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BibTeX
@article{pan2026correlation,
title = {{Correlation of Glomerular MBL Deposition with the Clinicopathology and Prognosis of Idiopathic Membranous Nephropathy: A PLA2R Subgroup Analysis.}},
author = {Yan Pan and Yongxin Zhao and Xueping Wu and Bowen Chen and Mengru Lu and Dandan Shao and Lei Liu and Weidong Chen},
journal = {International journal of general medicine},
year = {2026},
month = oct,
doi = {10.2147/ijgm.s631116},
url = {https://europepmc.org/article/MED/42948706},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Correlation of Glomerular MBL Deposition with the Clinicopathology and Prognosis of Idiopathic Membranous Nephropathy: A PLA2R Subgroup Analysis.
AU - Yan Pan
AU - Yongxin Zhao
AU - Xueping Wu
AU - Bowen Chen
AU - Mengru Lu
AU - Dandan Shao
AU - Lei Liu
AU - Weidong Chen
PY - 2026
DA - 2026/10/23
JO - International journal of general medicine
DO - 10.2147/ijgm.s631116
UR - https://europepmc.org/article/MED/42948706
AB - Background and objective This study investigates the correlation between mannose-binding lectin(MBL)and autoantibody IgG4 against the phospholipase A2 receptor (PLA2R) in idiopathic membranous nephropathy(IMN), as well as the role of MBL in the pathogenesis, clinicopathology, and prognosis of IMN.Methods Thirty-nine patients with IMN from our hospital between 2021 and 2022 were divided into positive and negative groups based on glomerular MBL immunofluorescence results and anti-PLA2R antibody status. Clinical, pathological, and follow-up data were analyzed.Results Among the 39 patients, the positive rates of glomerular MBL deposition, IgG4 deposition, and serum anti-PLA2R antibodies were 79.5%, 100%, and 66.7%, respectively. There were no significant differences in clinical and pathological features between MBL-positive and-negative groups, but renal tissue IgG4 expression differed (p<0.05). No significant differences in MBL deposition were found among IMN patients grouped by serum PLA2R antibody levels. Renal tissue C1q expression was low (15.38%). Univariate and multivariate Cox regression analyses showed that lower body weight and C3 negativity were independent promoting factors for patient improved prognosis (P<0.05). Kaplan-Meier survival analysis indicated that there were no significant differences in complete remission, partial remission, and relapse between MBL deposition positive and negative patients (P>0.05).Conclusion Glomerular MBL deposition correlates with renal tissue IgG4 deposition (p=0.03), suggesting participation in IMN pathogenesis via lectin-pathway complement activation. However, no significant difference in MBL deposition was found between patients grouped by serum anti-PLA2R antibody status, nevertheless, its presence or absence exerts no significant impact on clinical presentation, pathology, or prognosis. In the exploratory Cox regression analysis, negative glomerular C3a deposition was associated with a higher likelihood of remission, though this requires validation in larger cohorts.
SN - 1178-7074
ER -