Skip to content
DraconiticResearch
Search Sources API
201,683 studies31 sourcesUpdated 59 min ago
PreprintCC BYmedRxiv

Peripheral immunoinflammatory markers and clinical correlations in Parkinson's disease patients carrying LRRK2 G2385R and R1628P variants

  • H. X. Ding
  • T. S. Toh
  • N. J. Zulkefli
  • N. S. Zulhaimi
  • A. N. Khairul Anuar
  • J. W. Hor
  • Y. W. Tay
  • I. X. Kong
  • Y. C. Pang
  • R. Rajasuriar
  • S.-Y. Lim
  • A. H. Tan
1 more authors
  • L. C. Lit1
  1. 1Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Read full textPDFDOICite

Abstract

Peripheral inflammation in Parkinsons disease (PD) remains poorly characterised among carriers of Asian-prevalent LRRK2 G2385R and R1628P variants. We investigated plasma immunoinflammatory markers (i.e., IL-6, TNF-, CCL2, CX3CL1, CCL5, and VCAM-1) via multiplex immunoassay in 240 participants: PD-G2385R (n=53), PD-R1628P (n=58), PD-G2385R+R1628P (n=5), idiopathic PD (iPD; n=62), and controls (n=62), and their clinicobiological correlates including monocyte LRRK2 kinase activity (pRab10Thr73). Compared with iPD and/or controls, TNF-, CCL2, CX3CL1, and CCL5 were lower in PD-G2385R, while IL-6, TNF-, CCL2, and CCL5 were lower in PD-R1628P. Higher LRRK2 kinase activity correlated with lower TNF-. CX3CL1 correlated with greater motor severity in iPD but less disability in both variant groups. CCL5 correlated with less motor complications in PD-G2385R, while IL-6 and VCAM-1 correlated with worse disability and/or cognition in PD-R1628P. These findings suggest that immunoinflammatory profiles and their clinical relevance in PD differ by genotype, with implications for stratification in future immunomodulatory trials.

Related

  1. Correlation of peripheral blood BMAL1 level with non-motor symptoms in Parkinson’s disease patients
    Yanyan Jiang, Yufei Zhang, Luoqing Dong +1
    Frontiers in neurologyPeer-reviewedCC BYFull textNeurologyEurope PMC
  2. Autologous Peripheral Blood-Derived Stem Cells Combined with Platelet-Rich Plasma is Associated With Clinical and Radiological Improvement in Anterior Cruciate Ligament Ruptures—Preliminary Clinical and MRI Findings in 47 Consecutive Patients
    Patrick Weninger, Andreas Herbst, Veronika Pfafl-Weninger +1
    Indian journal of orthopaedicsPeer-reviewedCC BYFull textSurgery & anaesthesiaEurope PMC
  3. Clinical, epidemiological, and economic profile of patients with Parkinson disease eligible for neuromodulation
    T. A. Glinski, L. C. K. da Silva, J. L. R. N. da Luz +1
    medRxivPreprintCC BYFull textNeurologymedRxiv
  4. Interaction Between Exercise Intensity and Sedentary Behavior on VO2max Change in Patients with De Novo Parkinson Disease: The Study in Parkinson Disease of Exercise (SPARX) Phase 2 Randomized Clinical Trial
    B. J. Pae, T. S. Novak, G. J. Griffith +5
    medRxivPreprintCC BY-NCFull textNeurologymedRxiv
  5. Evaluation of peripheral and intranigral AAV-mediated Irisin delivery in a chronic AAV-A53T α-Synuclein overexpression mouse model of Parkinson’s disease
    Chunyan Shu, Jiehong Huang, Wandi Pu +4
    Frontiers in aging neurosciencePeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@misc{ding2026peripheral,
  title = {{Peripheral immunoinflammatory markers and clinical correlations in Parkinson's disease patients carrying LRRK2 G2385R and R1628P variants}},
  author = {H. X. Ding and T. S. Toh and N. J. Zulkefli and N. S. Zulhaimi and A. N. Khairul Anuar and J. W. Hor and Y. W. Tay and I. X. Kong and Y. C. Pang and R. Rajasuriar and S.-Y. Lim and A. H. Tan and L. C. Lit},
  howpublished = {medRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.20.26363505},
  url = {https://www.medrxiv.org/content/10.64898/2026.09.20.26363505v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Peripheral immunoinflammatory markers and clinical correlations in Parkinson's disease patients carrying LRRK2 G2385R and R1628P variants
AU  - H. X. Ding
AU  - T. S. Toh
AU  - N. J. Zulkefli
AU  - N. S. Zulhaimi
AU  - A. N. Khairul Anuar
AU  - J. W. Hor
AU  - Y. W. Tay
AU  - I. X. Kong
AU  - Y. C. Pang
AU  - R. Rajasuriar
AU  - S.-Y. Lim
AU  - A. H. Tan
AU  - L. C. Lit
PY  - 2026
DA  - 2026/09/20
PB  - medRxiv
DO  - 10.64898/2026.09.20.26363505
UR  - https://www.medrxiv.org/content/10.64898/2026.09.20.26363505v1
AB  - Peripheral inflammation in Parkinsons disease (PD) remains poorly characterised among carriers of Asian-prevalent LRRK2 G2385R and R1628P variants. We investigated plasma immunoinflammatory markers (i.e., IL-6, TNF-, CCL2, CX3CL1, CCL5, and VCAM-1) via multiplex immunoassay in 240 participants: PD-G2385R (n=53), PD-R1628P (n=58), PD-G2385R+R1628P (n=5), idiopathic PD (iPD; n=62), and controls (n=62), and their clinicobiological correlates including monocyte LRRK2 kinase activity (pRab10Thr73). Compared with iPD and/or controls, TNF-, CCL2, CX3CL1, and CCL5 were lower in PD-G2385R, while IL-6, TNF-, CCL2, and CCL5 were lower in PD-R1628P. Higher LRRK2 kinase activity correlated with lower TNF-. CX3CL1 correlated with greater motor severity in iPD but less disability in both variant groups. CCL5 correlated with less motor complications in PD-G2385R, while IL-6 and VCAM-1 correlated with worse disability and/or cognition in PD-R1628P. These findings suggest that immunoinflammatory profiles and their clinical relevance in PD differ by genotype, with implications for stratification in future immunomodulatory trials.
ER  -