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Peer-reviewedCC BY 4.0Cell Reports

Optogenetic reduction of theta oscillations induces remapping of time cells without memory impairment

  • Hyun Choong Yong1
  • HaoRan Chang2
  • Mark P. Brandon3
  1. 1Department of Psychiatry, Douglas Hospital Research Centre, McGill University, Montreal, QC, Canada; Integrated Program in Neuroscience (IPN), McGill University, Montreal, QC, Canada
  2. 2Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
  3. 3Department of Psychiatry, Douglas Hospital Research Centre, McGill University, Montreal, QC, Canada; Integrated Program in Neuroscience (IPN), McGill University, Montreal, QC, Canada. Electronic address: [email protected]
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Abstract

In a delayed alternation spatial working memory task, hippocampal time cells fire during specific moments of the delay period to form a sequential representation of the entire delay interval. The causal relationship between these sequences and working memory remains unclear. Similarly, hippocampal theta oscillations are thought to support working memory, primarily through the generation of time cell sequences. To causally examine these relationships, we optogenetically silence the medial septal GABAergic theta-generating circuit during the delay portion of a delayed spatial alternation task. With hippocampal theta oscillations substantially reduced, many time cells exhibit remapping, and new time cells are recruited. Despite partial remapping of time cell sequences, behavioral performance remains intact and trajectory-specific coding is preserved, suggesting that task-relevant information remains available under theta disruption.

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Cite

BibTeXRIS
BibTeX
@article{yong2026optogenetic,
  title = {{Optogenetic reduction of theta oscillations induces remapping of time cells without memory impairment}},
  author = {Hyun Choong Yong and HaoRan Chang and Mark P. Brandon},
  journal = {Cell Reports},
  year = {2026},
  month = oct,
  doi = {10.1016/j.celrep.2026.118192},
  url = {https://linkinghub.elsevier.com/retrieve/pii/S2211124726012714},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Optogenetic reduction of theta oscillations induces remapping of time cells without memory impairment
AU  - Hyun Choong Yong
AU  - HaoRan Chang
AU  - Mark P. Brandon
PY  - 2026
DA  - 2026/10/21
JO  - Cell Reports
DO  - 10.1016/j.celrep.2026.118192
UR  - https://linkinghub.elsevier.com/retrieve/pii/S2211124726012714
AB  - In a delayed alternation spatial working memory task, hippocampal time cells fire during specific moments of the delay period to form a sequential representation of the entire delay interval. The causal relationship between these sequences and working memory remains unclear. Similarly, hippocampal theta oscillations are thought to support working memory, primarily through the generation of time cell sequences. To causally examine these relationships, we optogenetically silence the medial septal GABAergic theta-generating circuit during the delay portion of a delayed spatial alternation task. With hippocampal theta oscillations substantially reduced, many time cells exhibit remapping, and new time cells are recruited. Despite partial remapping of time cell sequences, behavioral performance remains intact and trajectory-specific coding is preserved, suggesting that task-relevant information remains available under theta disruption.
SN  - 2211-1247
SN  - 2639-1856
ER  -