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Peer-reviewedCC BY 4.0Bioinorganic Chemistry and Applications

Ruthenium(II) Carbosilane Dendrimers With Aliphatic Polyamine Ligands for In Vivo Antimelanoma Activity

  • Yoel Garrosa-Miró1,2
  • Lorena García Hevia3,4
  • Mónica L. Fanarraga3,5
  • Paula Ortega1,2
  • Francisco Javier de la Mata1,2
5 affiliations
  1. 1Department of Organic Chemistry and Inorganic Chemistry Research Institute of Chemistry ‘Andrés M. Del Rio (IQAR)’ Institute “Ramón y Cajal” for Health Research (IRYCIS) University of Alcalá 28805 Madrid Spain uah.es
  2. 2Networking Research Center on Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN) 28029 Madrid Spain
  3. 3The Nanomedicine Group Universidad de Cantabria-IDIVAL Avda Herrera Oria s/n 39011 Santander Spain unican.es
  4. 4Departamento de Anatomía y Biología Celular Universidad de Cantabria Santander Spain unican.es
  5. 5Molecular Biology Department Faculty of Medicine Universidad de Cantabria 39011 Santander Spain unican.es
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Abstract

Metastatic melanoma remains a major therapeutic challenge due to the limited efficacy of current systemic treatments, which is motivating the development of alternative drug delivery strategies. Herein, we report the synthesis and characterization of carbosilane metallodendrimers functionalized with Ru(II) complexes bearing norspermidine‐derived ligands and evaluate their anticancer activity using malignant melanoma as a model of aggressive cancer. In vitro and in vivo studies demonstrate that these macromolecular systems exhibit enhanced antitumour activity compared with their mononuclear ruthenium counterparts. Notably, the second‐generation metallodendrimer produced a remarkable antitumour response in vivo, reducing tumour mass by more than 65% after single administration. These findings indicate that the biological performance of these Ru(II)‐based systems depends not only on the presence of multiple metal centres but also on the nanoscale dendritic architecture, highlighting the potential of metallodendrimers as macromolecular platforms for anticancer therapy.

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Cite

BibTeXRIS
BibTeX
@article{garrosamiro2026rutheniumii,
  title = {{Ruthenium(II) Carbosilane Dendrimers With Aliphatic Polyamine Ligands for In Vivo Antimelanoma Activity}},
  author = {Yoel Garrosa-Miró and Lorena García Hevia and Mónica L. Fanarraga and Paula Ortega and Francisco Javier de la Mata},
  journal = {Bioinorganic Chemistry and Applications},
  year = {2026},
  month = oct,
  doi = {10.1155/bca/4574339},
  url = {https://doi.org/10.1155/bca/4574339},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Ruthenium(II) Carbosilane Dendrimers With Aliphatic Polyamine Ligands for In Vivo Antimelanoma Activity
AU  - Yoel Garrosa-Miró
AU  - Lorena García Hevia
AU  - Mónica L. Fanarraga
AU  - Paula Ortega
AU  - Francisco Javier de la Mata
PY  - 2026
DA  - 2026/10/26
JO  - Bioinorganic Chemistry and Applications
DO  - 10.1155/bca/4574339
UR  - https://doi.org/10.1155/bca/4574339
AB  - Metastatic melanoma remains a major therapeutic challenge due to the limited efficacy of current systemic treatments, which is motivating the development of alternative drug delivery strategies. Herein, we report the synthesis and characterization of carbosilane metallodendrimers functionalized with Ru(II) complexes bearing norspermidine‐derived ligands and evaluate their anticancer activity using malignant melanoma as a model of aggressive cancer. In vitro and in vivo studies demonstrate that these macromolecular systems exhibit enhanced antitumour activity compared with their mononuclear ruthenium counterparts. Notably, the second‐generation metallodendrimer produced a remarkable antitumour response in vivo, reducing tumour mass by more than 65% after single administration. These findings indicate that the biological performance of these Ru(II)‐based systems depends not only on the presence of multiple metal centres but also on the nanoscale dendritic architecture, highlighting the potential of metallodendrimers as macromolecular platforms for anticancer therapy.
SN  - 1565-3633
SN  - 1687-479X
ER  -