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Peer-reviewedLicence not statedNature Genetics

Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease

  • Donghoon Lee1,2,3,4,5,6,7,8
  • James M. Vicari9,10,11,12
  • Christian Porras9,10,11,12,5,6,7,8
  • Colleen Spencer9,10,11,12,5,6,7,8
  • Milos Pjanic9,10,11,12,5,6,7,8
  • Xinyi Wang9,10,11,12,5,6,7,8
  • Seon Kinrot9,10,11,12
  • Philipp Weiler13,14
  • Roman Kosoy9,10,11,12,5,6,7,8
  • Jaroslav M. Bendl9,10,11,12,5,6,7,8
  • N. M. Prashant9,10,11,12,6,8
  • Konstantina Psychogyiou9,10,11,12
23 more authors
  • Periklis Malakates9,10,11,12
  • Evelyn Hennigan9,10,11,12
  • Jennifer Monteiro Fortes9,10,11,12
  • Shiwei Zheng15,10,16,17,6
  • Karen Therrien9,10,11,12,5,6,7,8
  • Deepika Dayal Mathur9,10,11,12,5,6,7,8
  • Steven P. Kleopoulos9,10,11,12,5,6,7,8
  • Zhiping Shao9,10,11,12,5,6,7,8
  • Stathis Argyriou9,10,11,12,5,6,7,8
  • Marcela Alvia9,10,11,12,5,6,7,8
  • Clara Casey9,10,11,12,5,6,7,8
  • Aram Hong9,10,11,12,5,6,7,8
  • Kristin G. Beaumont10,6
  • Robert Sebra10,6
  • Christopher Paul Kellner18,19
  • David Alan Bennett20
  • Guo‐Cheng Yuan15,10,16,17,6
  • Georgios Voloudakis9,21,10,11,12,22,5,6,7,8
  • Fabian Joachim Theis13,14,23
  • Vahram H. Haroutunian24,11,12,22,25,7,8,26
  • Gabriel E. Hoffman9,21,10,11,12,22,5,6,7,8
  • John F. Fullard9,10,11,12,5,6,7,8
  • Panos Roussos27,28,29,30,31,32,5,6,7,8,26
32 affiliations
  1. 1Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. [email protected]
  2. 2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. [email protected]
  3. 3Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. [email protected]
  4. 4Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. [email protected]
  5. 5Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  6. 6Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  7. 7Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  8. 8Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  9. 9Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  10. 10Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  11. 11Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  12. 12Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  13. 13Department of Mathematics, Technical University of Munich, Munich, Germany
  14. 14Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany
  15. 15Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  16. 16Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  17. 17Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
  18. 18Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  19. 19Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  20. 20Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA
  21. 21Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, Bronx, NY, USA
  22. 22Mental Illness Research, Education and Clinical Centers, James J. Peters VA Medical Center, Bronx, NY, USA
  23. 23TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany
  24. 24Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
  25. 25Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  26. 26Mental Illness Research, Education and Clinical Centers, James J. Peters VA Medical Center, Bronx, New York
  27. 27Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. [email protected]
  28. 28Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, Bronx, NY, USA. [email protected]
  29. 29Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. [email protected]
  30. 30Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. [email protected]
  31. 31Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. [email protected]
  32. 32Mental Illness Research, Education and Clinical Centers, James J. Peters VA Medical Center, Bronx, NY, USA. [email protected]
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Cite

BibTeXRIS
BibTeX
@article{lee2026plasticity,
  title = {{Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease}},
  author = {Donghoon Lee and James M. Vicari and Christian Porras and Colleen Spencer and Milos Pjanic and Xinyi Wang and Seon Kinrot and Philipp Weiler and Roman Kosoy and Jaroslav M. Bendl and N. M. Prashant and Konstantina Psychogyiou and Periklis Malakates and Evelyn Hennigan and Jennifer Monteiro Fortes and Shiwei Zheng and Karen Therrien and Deepika Dayal Mathur and Steven P. Kleopoulos and Zhiping Shao and Stathis Argyriou and Marcela Alvia and Clara Casey and Aram Hong and Kristin G. Beaumont and Robert Sebra and Christopher Paul Kellner and David Alan Bennett and Guo‐Cheng Yuan and Georgios Voloudakis and Fabian Joachim Theis and Vahram H. Haroutunian and Gabriel E. Hoffman and John F. Fullard and Panos Roussos},
  journal = {Nature Genetics},
  year = {2026},
  month = aug,
  doi = {10.1038/s41588-026-02716-6},
  url = {https://doi.org/10.1101/2023.10.25.23297558},
}
RIS
TY  - JOUR
TI  - Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease
AU  - Donghoon Lee
AU  - James M. Vicari
AU  - Christian Porras
AU  - Colleen Spencer
AU  - Milos Pjanic
AU  - Xinyi Wang
AU  - Seon Kinrot
AU  - Philipp Weiler
AU  - Roman Kosoy
AU  - Jaroslav M. Bendl
AU  - N. M. Prashant
AU  - Konstantina Psychogyiou
AU  - Periklis Malakates
AU  - Evelyn Hennigan
AU  - Jennifer Monteiro Fortes
AU  - Shiwei Zheng
AU  - Karen Therrien
AU  - Deepika Dayal Mathur
AU  - Steven P. Kleopoulos
AU  - Zhiping Shao
AU  - Stathis Argyriou
AU  - Marcela Alvia
AU  - Clara Casey
AU  - Aram Hong
AU  - Kristin G. Beaumont
AU  - Robert Sebra
AU  - Christopher Paul Kellner
AU  - David Alan Bennett
AU  - Guo‐Cheng Yuan
AU  - Georgios Voloudakis
AU  - Fabian Joachim Theis
AU  - Vahram H. Haroutunian
AU  - Gabriel E. Hoffman
AU  - John F. Fullard
AU  - Panos Roussos
PY  - 2026
DA  - 2026/08/11
JO  - Nature Genetics
DO  - 10.1038/s41588-026-02716-6
UR  - https://doi.org/10.1101/2023.10.25.23297558
SN  - 1061-4036
SN  - 1546-1718
ER  -