Sarrella massiliensis gen. nov. sp. nov., a new gut genus isolated from the stool of a healthy donor

Abstract

Strain Marseille-QA0792 (=CSUR QA0792, CECT 31199) was isolated from the feces of a healthy person using the culturomics method. The fecal sample originated from leftover material collected for a fecal microbiota transplantation (FMT) procedure, obtained during a routine screening in accordance with the guidelines of the French National Agency for Medicines and Health Products Safety (ANSM). This strain is Gram-stain-negative, rod-shaped, non-motile, and non-spore-forming. It is strictly anaerobic, with optimal growth at 37{degrees}C. Strain Marseille-QA0792 presented its highest 16S rRNA identity, 96.2%, with ''Merdibacter massiliensis'' strain Marseille-P3254 (not validly published) (accession number LT598590) and ANI similarity of 75.0% with the same species. Among validly published species, strain Marseille-QA0792 showed its highest 16S rRNA gene sequence similarity (91.5%) with Faecalicoccus acidiformans strain 37-2a (accession number HQ452864), whereas all computed average nucleotide identity (ANI) values were below 75%. Genome sequencing revealed a genome size of 2.67 Mb and a G+C content of 50.01%. This species is classified within the Erysipelotrichaceae family in the Bacillota phylum. Thus, we isolated for the first time a novel genus named Sarrella massiliensis gen. nov., sp. nov., strain Marseille-QA0792. This discovery highlights the importance of continuing culturomics efforts to explore the human microbiome.

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BibTeX RIS

BibTeX

@misc{semmar2026sarrella,
  title = {{Sarrella massiliensis gen. nov. sp. nov., a new gut genus isolated from the stool of a healthy donor}},
  author = {R. Semmar and M. Beye and N. Orain and S. Robinne and S. Alibar and S. Bakour and J.-C. Lagier and G. Dubourg and M. Tidjani Alou and C. Valles},
  howpublished = {bioRxiv},
  year = {2026},
  month = nov,
  doi = {10.64898/2026.11.03.764080},
  url = {https://www.biorxiv.org/content/10.64898/2026.11.03.764080v1},
  note = {CC BY},
}

RIS

TY  - UNPB
TI  - Sarrella massiliensis gen. nov. sp. nov., a new gut genus isolated from the stool of a healthy donor
AU  - R. Semmar
AU  - M. Beye
AU  - N. Orain
AU  - S. Robinne
AU  - S. Alibar
AU  - S. Bakour
AU  - J.-C. Lagier
AU  - G. Dubourg
AU  - M. Tidjani Alou
AU  - C. Valles
PY  - 2026
DA  - 2026/11/03
PB  - bioRxiv
DO  - 10.64898/2026.11.03.764080
UR  - https://www.biorxiv.org/content/10.64898/2026.11.03.764080v1
AB  - Strain Marseille-QA0792 (=CSUR QA0792, CECT 31199) was isolated from the feces of a healthy person using the culturomics method. The fecal sample originated from leftover material collected for a fecal microbiota transplantation (FMT) procedure, obtained during a routine screening in accordance with the guidelines of the French National Agency for Medicines and Health Products Safety (ANSM). This strain is Gram-stain-negative, rod-shaped, non-motile, and non-spore-forming. It is strictly anaerobic, with optimal growth at 37{degrees}C. Strain Marseille-QA0792 presented its highest 16S rRNA identity, 96.2%, with ''Merdibacter massiliensis'' strain Marseille-P3254 (not validly published) (accession number LT598590) and ANI similarity of 75.0% with the same species. Among validly published species, strain Marseille-QA0792 showed its highest 16S rRNA gene sequence similarity (91.5%) with Faecalicoccus acidiformans strain 37-2a (accession number HQ452864), whereas all computed average nucleotide identity (ANI) values were below 75%. Genome sequencing revealed a genome size of 2.67 Mb and a G+C content of 50.01%. This species is classified within the Erysipelotrichaceae family in the Bacillota phylum. Thus, we isolated for the first time a novel genus named Sarrella massiliensis gen. nov., sp. nov., strain Marseille-QA0792. This discovery highlights the importance of continuing culturomics efforts to explore the human microbiome.
ER  -

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