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Peer-reviewedCC BY-NC-ND 4.0Npj Women's Health

Spatially mapping the mechanical and structural properties of the seedling uterine fibroid-myometrium interface

  • Daniella M. Fodera1
  • Alara Sutcu2,3
  • Arielle S. Joasil4
  • Aidan M. Therien4
  • Johanna L. L. Jackson1
  • Arnold P. Advincula5
  • Xiaowei Chen6
  • Christine P. Hendon4
  • Michelle L. Oyen7
  • Tal Korem3,5
  • Kristin M. Myers8
8 affiliations
  1. 1Department of Biomedical Engineering, Columbia University, New York, NY USA
  2. 2Institute of Human Nutrition, Columbia University Irving Medical Center, New York, NY USA
  3. 3Program for Mathematical Genomics, Department of Systems Biology, Columbia University Irving Medical Center, New York, NY USA
  4. 4Department of Electrical Engineering, Columbia University, New York, NY USA
  5. 5Department of Obstetrics & Gynecology, Columbia University Irving Medical Center, New York, NY USA
  6. 6Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY USA
  7. 7Department of Biomedical Engineering, Wayne State University, Detroit, MI USA
  8. 8Department of Mechanical Engineering, Columbia University, New York, NY USA
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Abstract

Uterine fibroids (leiomyomas) are highly prevalent, noncancerous tumors canonically described as stiff and collagen-dense. Still, the mechanical heterogeneity within uterine fibroids and the alterations that occur at the fibroid-myometrium interface remain poorly understood. This study quantitatively maps the local mechanical, structural, and compositional properties of seedling uterine fibroids (< 1 cm) at the interface region. Relative to patient-matched myometrial tissues, uterine fibroids exhibited increased stiffness, decreased permeability, increased diffusivity, decreased hydration, greater collagen content, and distinct collagen organization. At the fibroid-myometrium interface, a band of aligned myometrial fibers immediately adjacent to the fibroid was observed, and heterogeneous spatial patterns in elastic modulus and permeability were identified. Ultimately, this study establishes foundational knowledge on the mechanics and structure of seedling uterine fibroids, facilitating future developments of clinically translatable detection tools.

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Cite

BibTeXRIS
BibTeX
@article{fodera2026spatially,
  title = {{Spatially mapping the mechanical and structural properties of the seedling uterine fibroid-myometrium interface}},
  author = {Daniella M. Fodera and Alara Sutcu and Arielle S. Joasil and Aidan M. Therien and Johanna L. L. Jackson and Arnold P. Advincula and Xiaowei Chen and Christine P. Hendon and Michelle L. Oyen and Tal Korem and Kristin M. Myers},
  journal = {Npj Women's Health},
  year = {2026},
  month = jul,
  doi = {10.1038/s44294-026-00152-9},
  url = {https://doi.org/10.1038/s44294-026-00152-9},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Spatially mapping the mechanical and structural properties of the seedling uterine fibroid-myometrium interface
AU  - Daniella M. Fodera
AU  - Alara Sutcu
AU  - Arielle S. Joasil
AU  - Aidan M. Therien
AU  - Johanna L. L. Jackson
AU  - Arnold P. Advincula
AU  - Xiaowei Chen
AU  - Christine P. Hendon
AU  - Michelle L. Oyen
AU  - Tal Korem
AU  - Kristin M. Myers
PY  - 2026
DA  - 2026/07/07
JO  - Npj Women's Health
DO  - 10.1038/s44294-026-00152-9
UR  - https://doi.org/10.1038/s44294-026-00152-9
AB  - Uterine fibroids (leiomyomas) are highly prevalent, noncancerous tumors canonically described as stiff and collagen-dense. Still, the mechanical heterogeneity within uterine fibroids and the alterations that occur at the fibroid-myometrium interface remain poorly understood. This study quantitatively maps the local mechanical, structural, and compositional properties of seedling uterine fibroids (< 1 cm) at the interface region. Relative to patient-matched myometrial tissues, uterine fibroids exhibited increased stiffness, decreased permeability, increased diffusivity, decreased hydration, greater collagen content, and distinct collagen organization. At the fibroid-myometrium interface, a band of aligned myometrial fibers immediately adjacent to the fibroid was observed, and heterogeneous spatial patterns in elastic modulus and permeability were identified. Ultimately, this study establishes foundational knowledge on the mechanics and structure of seedling uterine fibroids, facilitating future developments of clinically translatable detection tools.
SN  - 2948-1716
ER  -