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Peer-reviewedCC BY-NC-NDSTAR protocols

Protocol for an immunocompetent KPC mouse model of pancreatic cancer resection and recurrence for perioperative treatment studies.

  • Jacob L Léger1
  • Nawal Amhis2
  • Sarah Mansouri2
  • Maria Fernanda Meza Pacheco1
  • Lauren Daniel1
  • Hugo Giguère1
  • Yves Collin3
  • Lee-Hwa Tai4
4 affiliations
  1. 1Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
  2. 2Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Department of Surgery, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
  3. 3Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Department of Surgery, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
  4. 4Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada. Electronic address: [email protected].
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Abstract

In mouse models of pancreatic ductal adenocarcinoma, surgical removal of orthotopic tumors typically involves removing the primary tumor along with the spleen. Here, we present a protocol for surgical removal of the tumor in the tail of the pancreas while preserving the spleen. We describe steps for implantation of mouse pancreatic cancer cells followed by the identification and removal of the orthotopic tumor. We also outline perioperative treatment strategies for tumor recurrence.

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Cite

BibTeXRIS
BibTeX
@article{leger2026protocol,
  title = {{Protocol for an immunocompetent KPC mouse model of pancreatic cancer resection and recurrence for perioperative treatment studies.}},
  author = {Jacob L Léger and Nawal Amhis and Sarah Mansouri and Maria Fernanda Meza Pacheco and Lauren Daniel and Hugo Giguère and Yves Collin and Lee-Hwa Tai},
  journal = {STAR protocols},
  year = {2026},
  month = oct,
  doi = {10.1016/j.xpro.2026.104897},
  url = {https://europepmc.org/article/MED/42858257},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Protocol for an immunocompetent KPC mouse model of pancreatic cancer resection and recurrence for perioperative treatment studies.
AU  - Jacob L Léger
AU  - Nawal Amhis
AU  - Sarah Mansouri
AU  - Maria Fernanda Meza Pacheco
AU  - Lauren Daniel
AU  - Hugo Giguère
AU  - Yves Collin
AU  - Lee-Hwa Tai
PY  - 2026
DA  - 2026/10/10
JO  - STAR protocols
DO  - 10.1016/j.xpro.2026.104897
UR  - https://europepmc.org/article/MED/42858257
AB  - In mouse models of pancreatic ductal adenocarcinoma, surgical removal of orthotopic tumors typically involves removing the primary tumor along with the spleen. Here, we present a protocol for surgical removal of the tumor in the tail of the pancreas while preserving the spleen. We describe steps for implantation of mouse pancreatic cancer cells followed by the identification and removal of the orthotopic tumor. We also outline perioperative treatment strategies for tumor recurrence.
SN  - 2666-1667
ER  -