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PreprintCC BYChemRxiv

Research Progress and Applications of the Fundamental Principles of Soft Ionization Mass Spectrometry

  • jiehong Luo
  • luo jiehong
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Abstract

(1. Guangdong Huisheng Testing Technology Co., Ltd.) Abstract: Soft ionization mass spectrometry is widely applied in fields such as pharmaceuticals, cosmetics, environmental monitoring, and food safety; however, its fundamental principles remain subject to considerable debate, rendering it a "black-box" technology. This review summarizes the basic principles of electrospray ionization (ESI), matrix-assisted laser desorption (MALDI), and desorption electrospray ionization (DESI), and establishes "one theory, two equations, and three instruments" as the theoretical and practical foundation for soft ionization mass spectrometry. Furthermore, this study discusses the electromagnetic applications of soft ionization mass spectrometry, thereby expanding its scope of research and application.

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Cite

BibTeXRIS
BibTeX
@misc{luo2026research,
  title = {{Research Progress and Applications of the Fundamental Principles of Soft Ionization Mass Spectrometry}},
  author = {jiehong Luo and luo jiehong},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010190/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010190/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Research Progress and Applications of the Fundamental Principles of Soft Ionization Mass Spectrometry
AU  - jiehong Luo
AU  - luo jiehong
PY  - 2026
DA  - 2026/10/09
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010190/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010190/v1
AB  - (1. Guangdong Huisheng Testing Technology Co., Ltd.) Abstract: Soft ionization mass spectrometry is widely applied in fields such as pharmaceuticals, cosmetics, environmental monitoring, and food safety; however, its fundamental principles remain subject to considerable debate, rendering it a "black-box" technology. This review summarizes the basic principles of electrospray ionization (ESI), matrix-assisted laser desorption (MALDI), and desorption electrospray ionization (DESI), and establishes "one theory, two equations, and three instruments" as the theoretical and practical foundation for soft ionization mass spectrometry. Furthermore, this study discusses the electromagnetic applications of soft ionization mass spectrometry, thereby expanding its scope of research and application.
ER  -