The causal association between Celiac disease and Ankylosing spondylitis: a two-sample Mendelian randomization analysis.
- 1Department of Basic Medical Sciences, Qinghai University Medical College, Xining, Qinghai, 810016, China. [email protected].
- 2Department of Basic Medical Sciences, Qinghai University Medical College, Xining, Qinghai, 810016, China. [email protected].
Abstract
Objective
The concept of the gut-joint axis is often mentioned when exploring the pathogenesis of Ankylosing spondylitis (AS). This study aims to explore whether there is a causal association between Celiac disease (CeD) and AS.Method
Two-sample Mendelian randomization (MR) analysis was conducted using the CeD dataset (the largest pure CeD phenotype dataset in the IEU OpenGWAS database at the time of data retrieval, n = 24,269) and the AS dataset (strictly defined, from the IEU OpenGWAS database, n = 218,030). Inverse Variance Weighting (IVW) was adopted as the primary MR analysis method, supplemented by Weighted Median Estimator, MR-Egger regression, Simple Mode, and Weighted Mode to comprehensively evaluate the causal association between CeD and AS. Additionally, horizontal pleiotropy, heterogeneity, and leave-one-out analysis were performed to further evaluate the robustness and reliability of the results.Results
IVW analysis showed a positive causal effect of genetically predicted CeD on AS (OR: 1.435, 95% CI: 1.210-1.702, p = 3.34E-05), and the other four analytical methods also yielded consistent causal effect evaluation results. No significant horizontal pleiotropy or heterogeneity was observed in this study.Conclusion
MR analysis indicates that CeD may be a potential risk factor for AS, providing genetic evidence for the increased risk of AS in individuals with a genetic predisposition to CeD.
Related
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BibTeX
@article{chen2026causal,
title = {{The causal association between Celiac disease and Ankylosing spondylitis: a two-sample Mendelian randomization analysis.}},
author = {Meiqi Chen and Xiang Gao},
journal = {BMC rheumatology},
year = {2026},
month = jul,
doi = {10.1186/s41927-026-00679-z},
url = {https://europepmc.org/article/MED/42897623},
note = {CC BY},
}
RIS
TY - JOUR
TI - The causal association between Celiac disease and Ankylosing spondylitis: a two-sample Mendelian randomization analysis.
AU - Meiqi Chen
AU - Xiang Gao
PY - 2026
DA - 2026/07/01
JO - BMC rheumatology
DO - 10.1186/s41927-026-00679-z
UR - https://europepmc.org/article/MED/42897623
AB - Objective The concept of the gut-joint axis is often mentioned when exploring the pathogenesis of Ankylosing spondylitis (AS). This study aims to explore whether there is a causal association between Celiac disease (CeD) and AS.Method Two-sample Mendelian randomization (MR) analysis was conducted using the CeD dataset (the largest pure CeD phenotype dataset in the IEU OpenGWAS database at the time of data retrieval, n = 24,269) and the AS dataset (strictly defined, from the IEU OpenGWAS database, n = 218,030). Inverse Variance Weighting (IVW) was adopted as the primary MR analysis method, supplemented by Weighted Median Estimator, MR-Egger regression, Simple Mode, and Weighted Mode to comprehensively evaluate the causal association between CeD and AS. Additionally, horizontal pleiotropy, heterogeneity, and leave-one-out analysis were performed to further evaluate the robustness and reliability of the results.Results IVW analysis showed a positive causal effect of genetically predicted CeD on AS (OR: 1.435, 95% CI: 1.210-1.702, p = 3.34E-05), and the other four analytical methods also yielded consistent causal effect evaluation results. No significant horizontal pleiotropy or heterogeneity was observed in this study.Conclusion MR analysis indicates that CeD may be a potential risk factor for AS, providing genetic evidence for the increased risk of AS in individuals with a genetic predisposition to CeD.
SN - 2520-1026
ER -