Real-world epidemiology and renal outcomes of ADPKD in Türkiye: the PKD-TURK cohort.

@article{deger2026realworld,
  title = {{Real-world epidemiology and renal outcomes of ADPKD in Türkiye: the PKD-TURK cohort.}},
  author = {Serpil Muge Deger and Necmi Eren and Sibel Yucel Kocak and Gulay Ulusal Okyay and Beyhan Güvercin and Abdulmecit Yildiz and Halime Soyak Kabaca and Sabahat Alisir Ecder and Tahsin Karaaslan and Ayca Inci and Mehmet Asi Oktan and Mine Sebnem Karakan and Asil Demirezen and Ulver Boztepe Derici and Bartu Ediz and Ilhan Kurultak and Bulent Huddam and Ozlem Usalan and Ilker Atay and Aysun Toraman and Haci Hasan Yeter and Kursad Onec and Alper Azak and Kenan Turgutalp and Belda Dursun and Onur Tunca and Sinan Kazan and Tulin Akagun and Saliha Yıldırım and Emre Yasar and Hulya Colak and Hayri Ustun Arda and Selma Alagoz and Hamad Dheir and Musa Pinar and Ramazan Danis and Eren Eynel and Berna Yelken and Gursel Yildiz and Funda Sari and Serkan Bakirdogen and Bulent Kaya and Ozgur Can and Melike Betul Ogutmen and Metin Ergul and Sibel Gokcay Bek and Tevfik Ecder},
  journal = {BMC nephrology},
  year = {2026},
  month = jul,
  doi = {10.1186/s12882-026-05217-0},
  url = {https://europepmc.org/article/MED/42902287},
  note = {CC BY},
}

TY  - JOUR
TI  - Real-world epidemiology and renal outcomes of ADPKD in Türkiye: the PKD-TURK cohort.
AU  - Serpil Muge Deger
AU  - Necmi Eren
AU  - Sibel Yucel Kocak
AU  - Gulay Ulusal Okyay
AU  - Beyhan Güvercin
AU  - Abdulmecit Yildiz
AU  - Halime Soyak Kabaca
AU  - Sabahat Alisir Ecder
AU  - Tahsin Karaaslan
AU  - Ayca Inci
AU  - Mehmet Asi Oktan
AU  - Mine Sebnem Karakan
AU  - Asil Demirezen
AU  - Ulver Boztepe Derici
AU  - Bartu Ediz
AU  - Ilhan Kurultak
AU  - Bulent Huddam
AU  - Ozlem Usalan
AU  - Ilker Atay
AU  - Aysun Toraman
AU  - Haci Hasan Yeter
AU  - Kursad Onec
AU  - Alper Azak
AU  - Kenan Turgutalp
AU  - Belda Dursun
AU  - Onur Tunca
AU  - Sinan Kazan
AU  - Tulin Akagun
AU  - Saliha Yıldırım
AU  - Emre Yasar
AU  - Hulya Colak
AU  - Hayri Ustun Arda
AU  - Selma Alagoz
AU  - Hamad Dheir
AU  - Musa Pinar
AU  - Ramazan Danis
AU  - Eren Eynel
AU  - Berna Yelken
AU  - Gursel Yildiz
AU  - Funda Sari
AU  - Serkan Bakirdogen
AU  - Bulent Kaya
AU  - Ozgur Can
AU  - Melike Betul Ogutmen
AU  - Metin Ergul
AU  - Sibel Gokcay Bek
AU  - Tevfik Ecder
PY  - 2026
DA  - 2026/07/01
JO  - BMC nephrology
DO  - 10.1186/s12882-026-05217-0
UR  - https://europepmc.org/article/MED/42902287
AB  - Introduction  Real-world epidemiological and longitudinal outcome data on autosomal dominant polycystic kidney disease (ADPKD) remain limited in underrepresented populations, including Türkiye. We aimed to characterize the epidemiology, regional distribution, and renal outcomes of ADPKD in a large multicenter national cohort.Methods  In this retrospective multicenter study, adult patients with ADPKD were identified across tertiary nephrology centers in six regions of Türkiye (2010-2025). Study-based prevalence was calculated using Turkish Statistical Institute population data. Longitudinal renal outcomes were evaluated using serial eGFR measurements and Cox regression models identified predictors of ≥ 40% eGFR decline.Results  A total of 2361 patients were included (mean age 38.6 ± 14 years; 51.8% female). Median province-level study-based prevalence was 3.86 per 100,000 population (IQR 2.92-5.49), with substantial regional variation, highest in the Black Sea region (13.46 per 100,000). Study-based prevalence increased significantly over time (annual percent change 14.4%; 95% CI 13.1-15.6; p < 0.001). During a median follow-up of 6 years, 23.9% experienced a ≥ 40% eGFR decline and 10.5% progressed to kidney failure (eGFR < 15 ml/min/1.73m2). Median annual eGFR decline was - 3.33 mL/min/1.73 m²/year. In multivariable analysis, age (adjusted HR 1.02; 95% CI 1.00-1.03; p = 0.010) and hypertension (adjusted HR 2.33; 95% CI 1.25-4.32; p = 0.007) were independently associated with renal progression, whereas tolvaptan use was associated with a lower risk of progression (adjusted HR 0.56; 95% CI 0.37-0.85; p = 0.004). The Mayo Imaging Classification remained independently predictive of renal outcomes (p = 0.027).Conclusions  This large real-world multicenter cohort highlights the geographically heterogeneous study-based burden of ADPKD across participating regions of Türkiye. Increasing prevalence over time likely reflects improved disease recognition, whereas the relatively low study-based prevalence suggests persistent under-recognition of ADPKD. These findings provide important longitudinal outcome data from an underrepresented population and support the need for earlier detection and improved risk stratification in ADPKD.
SN  - 1471-2369
ER  -