Peer-reviewedCC BYStructural heart : the journal of the Heart Team
Transcatheter Mitral Valve Replacement: Clinical Challenges, Evolving Indications, and Future Directions.
12 affiliations
- 1Clinical Trials Center, Cardiovascular Research Foundation, New York, New York, USA.
- 2Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 3Department of Clinical Physiology and Echocardiography-Heart Valve Clinic, CHU Lille, Lille, France.
- 4Department of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany.
- 5Department of Interventional Cardiology, McGill University Health Centre, Montreal, Quebec, Canada.
- 6Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.
- 7Cardiology Department, Interbalkan Medical Center, Thessaloniki, Greece.
- 8Interventional Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
- 9Interventional Cardiology, Sutter Health California Pacific Medical Center, San Francisco, California, USA.
- 10Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
- 11Columbia University Medical Center, New York Presbyterian Hospital, New York, New York, USA.
- 12Medico-Surgical Department, Haut-Lévêque Cardiological Hospital; Bordeaux University Hospital, Pessac, France.
Abstract
Mitral regurgitation is a highly prevalent valvular heart disease and, when hemodynamically significant, is associated with adverse outcomes. Despite advances in surgical techniques and catheter-based edge-to-edge repair, a large number of patients remain untreated due to high surgical risk or anatomical limitations. Transcatheter mitral valve replacement (TMVR) has emerged as a promising therapeutic option for these patients. Over the past 15 years, the TMVR field has substantially progressed, with multiple devices advancing to human clinical evaluation. This review aims to provide an overview of the key milestones in TMVR development, patient selection pathways, and the transition from transapical to transseptal delivery. We further summarize the available clinical outcomes across different platforms and discuss remaining knowledge gaps, as well as future directions for this evolving field.
Related
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BibTeX
@article{ascione2026transcatheter,
title = {{Transcatheter Mitral Valve Replacement: Clinical Challenges, Evolving Indications, and Future Directions.}},
author = {Guido Ascione and Sebastian Ludwig and Augustin Coisne and Philipp von Stein and Nicolo Piazza and Firas Zahr and Vlasis Ninios and D Scott Lim and David V Daniels and Charanjit S Rihal and Torsten P Vahl and Thomas Modine and Juan F Granada},
journal = {Structural heart : the journal of the Heart Team},
year = {2026},
month = sep,
doi = {10.1016/j.shj.2026.101125},
url = {https://europepmc.org/article/MED/42903629},
note = {CC BY},
}
RIS
TY - JOUR
TI - Transcatheter Mitral Valve Replacement: Clinical Challenges, Evolving Indications, and Future Directions.
AU - Guido Ascione
AU - Sebastian Ludwig
AU - Augustin Coisne
AU - Philipp von Stein
AU - Nicolo Piazza
AU - Firas Zahr
AU - Vlasis Ninios
AU - D Scott Lim
AU - David V Daniels
AU - Charanjit S Rihal
AU - Torsten P Vahl
AU - Thomas Modine
AU - Juan F Granada
PY - 2026
DA - 2026/09/07
JO - Structural heart : the journal of the Heart Team
DO - 10.1016/j.shj.2026.101125
UR - https://europepmc.org/article/MED/42903629
AB - Mitral regurgitation is a highly prevalent valvular heart disease and, when hemodynamically significant, is associated with adverse outcomes. Despite advances in surgical techniques and catheter-based edge-to-edge repair, a large number of patients remain untreated due to high surgical risk or anatomical limitations. Transcatheter mitral valve replacement (TMVR) has emerged as a promising therapeutic option for these patients. Over the past 15 years, the TMVR field has substantially progressed, with multiple devices advancing to human clinical evaluation. This review aims to provide an overview of the key milestones in TMVR development, patient selection pathways, and the transition from transapical to transseptal delivery. We further summarize the available clinical outcomes across different platforms and discuss remaining knowledge gaps, as well as future directions for this evolving field.
SN - 2474-8706
SN - 2474-8714
ER -