Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 45 min ago
Peer-reviewedCC BYFrontiers in immunology

Keratinocyte necroptosis in inflammatory skin diseases and acute epidermal injury: mechanisms, evidence, and therapeutic implications

  • Xu Liu1
  • Di Qu2
  • Jinyan Luo3
  • Bo Chen4
  • Xin Zhao5
  • Zhengxu Fu6
  • Jingdong Wu1
  • Fan Xia3
  • Yan Yan7
7 affiliations
  1. 1The First Clinical College, Liaoning University of Traditional Chinese Medicine , ,
  2. 2Department of Rehabilitation, Children's Hospital of Shenyang City , ,
  3. 3Chongqing Three Gorges Medical College , ,
  4. 4Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University , ,
  5. 5Department of Infection Management Section, Shenyang First People's Hospital , ,
  6. 6The First Clinical College, Shenyang Medical University , ,
  7. 7Department of Endocrinology and Metabolic Diseases, Shenyang First People's Hospital , ,
Read full textPDFDOICite

Abstract

The skin functions as a barrier against external insults and as an active immune organ. Keratinocytes are central to both roles, maintaining epidermal integrity while coordinating cutaneous immune responses. Necroptosis is a lytic form of regulated cell death that can compromise the epidermal barrier and release damage-associated molecular patterns, thereby linking tissue injury to immune activation. Accumulating evidence implicates keratinocyte necroptosis in multiple inflammatory skin diseases and acute epidermal injuries. This mini review summarizes the molecular regulation of keratinocyte necroptosis, critically appraises evidence for its involvement across distinct pathological contexts, and evaluates therapeutic strategies and associated translational challenges. Mechanistic studies and preliminary translational evidence suggest that necroptosis-related signaling in keratinocytes may represent a therapeutic target. However, the effects of pathway modulation may vary across disease contexts and depend on infection status and the immune microenvironment. Defining the disease-specific contribution of keratinocyte necroptosis and the corresponding therapeutic windows will therefore be essential for evaluating the clinical feasibility of this strategy.

Related

  1. Circular RNAs in tumor biology and immunology: molecular mechanisms and therapeutic implications
    Zhenyan Jiang, Yong Peng, Xiaojuan Yang
    Molecular CancerPeer-reviewedCC BYFull text1 citedMolecular biology & gene regulationDOAJ
  2. Epigenetic Rewiring of Enhancer–Promoter Interactions in Cancer: Mechanisms and Therapeutic Implications
    Lavanya Choppavarapu, Bakhtiyor Nosirov, Michael Kahn +1
    CancersPeer-reviewedCC BY 4.0Molecular biology & gene regulationCrossref
  3. Mitochondrial Dynamics in Diabetes Mellitus and Its Complications: Mechanisms, Pathological Roles, and Therapeutic Implications.
    Guohua Wang, Yige Zhao, Gaiting Liu +5
    International journal of molecular sciencesPeer-reviewedCC BYFull textMolecular biology & gene regulationEurope PMC
  4. Salidroside Regulates Energy Metabolism Reprogramming to Suppress Tumor Proliferation: Mechanisms and Therapeutic Implications
    Haolin Wang, Yuxin Du
    MetabolitesPeer-reviewedCC BY 4.0Full textMolecular biology & gene regulationCrossrefEurope PMC
  5. Gut microbiota in esophageal cancer: mechanisms, clinical implications, and therapeutic potential
    Yonghao Li, Lu Zhou, Ruixue Huang +6
    Frontiers in MicrobiologyPeer-reviewedCC BY 4.0Full textMolecular biology & gene regulationCrossrefEurope PMC

Cite

BibTeXRIS
BibTeX
@article{liu2026keratinocyte,
  title = {{Keratinocyte necroptosis in inflammatory skin diseases and acute epidermal injury: mechanisms, evidence, and therapeutic implications}},
  author = {Xu Liu and Di Qu and Jinyan Luo and Bo Chen and Xin Zhao and Zhengxu Fu and Jingdong Wu and Fan Xia and Yan Yan},
  journal = {Frontiers in immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1967855},
  url = {https://europepmc.org/article/PMC/PMC13673654},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Keratinocyte necroptosis in inflammatory skin diseases and acute epidermal injury: mechanisms, evidence, and therapeutic implications
AU  - Xu Liu
AU  - Di Qu
AU  - Jinyan Luo
AU  - Bo Chen
AU  - Xin Zhao
AU  - Zhengxu Fu
AU  - Jingdong Wu
AU  - Fan Xia
AU  - Yan Yan
PY  - 2026
DA  - 2026/10/02
JO  - Frontiers in immunology
DO  - 10.3389/fimmu.2026.1967855
UR  - https://europepmc.org/article/PMC/PMC13673654
AB  - The skin functions as a barrier against external insults and as an active immune organ. Keratinocytes are central to both roles, maintaining epidermal integrity while coordinating cutaneous immune responses. Necroptosis is a lytic form of regulated cell death that can compromise the epidermal barrier and release damage-associated molecular patterns, thereby linking tissue injury to immune activation. Accumulating evidence implicates keratinocyte necroptosis in multiple inflammatory skin diseases and acute epidermal injuries. This mini review summarizes the molecular regulation of keratinocyte necroptosis, critically appraises evidence for its involvement across distinct pathological contexts, and evaluates therapeutic strategies and associated translational challenges. Mechanistic studies and preliminary translational evidence suggest that necroptosis-related signaling in keratinocytes may represent a therapeutic target. However, the effects of pathway modulation may vary across disease contexts and depend on infection status and the immune microenvironment. Defining the disease-specific contribution of keratinocyte necroptosis and the corresponding therapeutic windows will therefore be essential for evaluating the clinical feasibility of this strategy.
SN  - 1664-3224
ER  -