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PreprintLicence not statedbioRxiv (Cold Spring Harbor Laboratory)

Efficient base editing and development in human embryos without chromosomal alterations

  • Stepan Jerabek1,2
  • Jimin Kim1
  • Julie Sung1
  • Chanju Jung3
  • Marcos Iuri Roos Kulmann4,5
  • Melisa Isado1
  • Hong-Su Jang6,7
  • Meng Li8
  • Sakshi Bhatele1
  • Michelle D. Kappy9
  • Shuangyi Xu1
  • Gue‐Ho Hwang10
6 more authors
  • Jia L. Xu11
  • Diego Marin12,11
  • Jae‐Sung Woo6
  • Sangsu Bae13,3,14
  • Nathan R. Treff15,11
  • Dieter M. Egli16,1,9
16 affiliations
  1. 1Columbia University, Department of Pediatrics, Division of Molecular Genetics, New York, USA
  2. 2Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic
  3. 3Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
  4. 4Department of Cell Biology, Charles University, Prague, Czech Republic
  5. 5Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
  6. 6Center for Biomolecular and Cellular Structure, Institute for Basic Science (IBS), Daejeon, Republic of Korea
  7. 7Department of Life Sciences, Korea University, Seoul, Republic of Korea
  8. 8Department of Medicine, Columbia University, New York, USA
  9. 9Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University, New York, USA
  10. 10Medical Research Center of Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
  11. 11Genomic Prediction Inc., 675 US Highway One, Suite 126 North Brunswick, New Jersey, USA
  12. 12Department of Human Genetics, Rutgers University, New Jersey, USA
  13. 13Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
  14. 14Medical Research Center of Genomic Medicine Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
  15. 15Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers University, New Jersey, USA
  16. 16Columbia Stem Cell Initiative, Columbia University, New York, USA
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Cite

BibTeXRIS
BibTeX
@misc{jerabek2026efficient,
  title = {{Efficient base editing and development in human embryos without chromosomal alterations}},
  author = {Stepan Jerabek and Jimin Kim and Julie Sung and Chanju Jung and Marcos Iuri Roos Kulmann and Melisa Isado and Hong-Su Jang and Meng Li and Sakshi Bhatele and Michelle D. Kappy and Shuangyi Xu and Gue‐Ho Hwang and Jia L. Xu and Diego Marin and Jae‐Sung Woo and Sangsu Bae and Nathan R. Treff and Dieter M. Egli},
  howpublished = {bioRxiv (Cold Spring Harbor Laboratory)},
  year = {2026},
  month = jun,
  doi = {10.64898/2026.05.30.728989},
  url = {https://doi.org/10.64898/2026.05.30.728989},
}
RIS
TY  - UNPB
TI  - Efficient base editing and development in human embryos without chromosomal alterations
AU  - Stepan Jerabek
AU  - Jimin Kim
AU  - Julie Sung
AU  - Chanju Jung
AU  - Marcos Iuri Roos Kulmann
AU  - Melisa Isado
AU  - Hong-Su Jang
AU  - Meng Li
AU  - Sakshi Bhatele
AU  - Michelle D. Kappy
AU  - Shuangyi Xu
AU  - Gue‐Ho Hwang
AU  - Jia L. Xu
AU  - Diego Marin
AU  - Jae‐Sung Woo
AU  - Sangsu Bae
AU  - Nathan R. Treff
AU  - Dieter M. Egli
PY  - 2026
DA  - 2026/06/01
PB  - bioRxiv (Cold Spring Harbor Laboratory)
DO  - 10.64898/2026.05.30.728989
UR  - https://doi.org/10.64898/2026.05.30.728989
ER  -