A Case Report: Diagnosis of Mycobacterium kansasii Infection by tNGS in a Patient With Parkinson's Disease.
- 1Department of Infectious Diseases Chongqing Wulong People's Hospital Wulong Chongqing 408500 China.
- 2Infection Diagnosis Center Sichuan Kingmed Center for Clinical Laboratory Co., Ltd Chengdu 610052 Sichuan China.
Abstract
Infections caused by nontuberculous mycobacteria (NTM), especially Mycobacterium kansasii, are characterized by nonspecific clinical manifestations. Moreover, their radiological features frequently overlap with those of both tuberculosis (TB) infections and lung cancer, which significantly complicates the differential diagnosis. We present a case of a patient with Parkinson's disease (PD) who was admitted with cough and sputum production and dyspnea. Chest computed tomography (CT) revealed atelectasis, multiple solid nodules, osteolytic lesions in multiple ribs, and pleural effusion. The initial diagnostic evaluation raised the suspicion of a lung cancer with multiple bone metastases. While acid-fast staining (AFS) of biopsy tissue was positive, polymerase chain reaction (PCR) for TB was negative. Ultimately, targeted next-generation sequencing (tNGS) of sputum detected M. kansasii, considering the diagnosis of pulmonary M. kansasii infection. This case highlights the need to consider M. kansasii infection in atypical imaging findings and the utility of tNGS for diagnosis when conventional tests are inconclusive.
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BibTeX
@article{gao2026case,
title = {{A Case Report: Diagnosis of Mycobacterium kansasii Infection by tNGS in a Patient With Parkinson's Disease.}},
author = {Shunmei Gao and Fangfang Deng and Gegang Wang},
journal = {Case reports in infectious diseases},
year = {2026},
month = oct,
doi = {10.1155/crdi/5084676},
url = {https://europepmc.org/article/MED/42959283},
note = {CC BY},
}
RIS
TY - JOUR
TI - A Case Report: Diagnosis of Mycobacterium kansasii Infection by tNGS in a Patient With Parkinson's Disease.
AU - Shunmei Gao
AU - Fangfang Deng
AU - Gegang Wang
PY - 2026
DA - 2026/10/28
JO - Case reports in infectious diseases
DO - 10.1155/crdi/5084676
UR - https://europepmc.org/article/MED/42959283
AB - Infections caused by nontuberculous mycobacteria (NTM), especially Mycobacterium kansasii, are characterized by nonspecific clinical manifestations. Moreover, their radiological features frequently overlap with those of both tuberculosis (TB) infections and lung cancer, which significantly complicates the differential diagnosis. We present a case of a patient with Parkinson's disease (PD) who was admitted with cough and sputum production and dyspnea. Chest computed tomography (CT) revealed atelectasis, multiple solid nodules, osteolytic lesions in multiple ribs, and pleural effusion. The initial diagnostic evaluation raised the suspicion of a lung cancer with multiple bone metastases. While acid-fast staining (AFS) of biopsy tissue was positive, polymerase chain reaction (PCR) for TB was negative. Ultimately, targeted next-generation sequencing (tNGS) of sputum detected M. kansasii, considering the diagnosis of pulmonary M. kansasii infection. This case highlights the need to consider M. kansasii infection in atypical imaging findings and the utility of tNGS for diagnosis when conventional tests are inconclusive.
SN - 2090-6625
SN - 2090-6633
ER -