Rapid Pain Reduction and Wound Closure Following Treatment With an Amorphous Silica-Based Fiber Wound Matrix in Partial-Thickness Thermal Burns: A Case Report.
- 1Research and Development, SiOxMed, Winston Salem, USA.
Abstract
Partial-thickness thermal burns can cause substantial pain and require effective wound management to support re-epithelialization. A 30-year-old man sustained 3%-4% total body surface area partial-thickness burns of the left hand, forearm, elbow, and abdomen following a gasoline-accelerated brush fire. Despite emergency debridement, dressings, and multimodal analgesia, pain remained 6-10/10. Approximately two days after injury, an amorphous silica-based fiber (SBF) wound matrix was applied to the open wounds, while a silica-based cream (SBC) was applied to surrounding intact skin. At initial SBF/SBC treatment, patient-reported pain decreased from 7/10 to 0/10 on a 0-10 numerical rating scale (NRS), with substantial relief reported within approximately 5-10 minutes. Across 12 paired assessments, mean pain decreased from 2.46/10 before treatment to 1.17/10 afterward. Serial planimetry demonstrated progressive wound closure with complete measured closure by Day 10, with sustained epithelial coverage and minimal scarring at Day 63. Because partial-thickness burns may spontaneously re-epithelialize, and this represents a single uncontrolled case with prior and concomitant treatment, causality cannot be established. The observed temporal pain response and wound-healing trajectory support prospective controlled evaluation using standardized pain, analgesic-use, epithelialization, functional, and safety endpoints.
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BibTeX
@article{jorgensen2026rapid,
title = {{Rapid Pain Reduction and Wound Closure Following Treatment With an Amorphous Silica-Based Fiber Wound Matrix in Partial-Thickness Thermal Burns: A Case Report.}},
author = {Adam M Jorgensen and William L Hickerson},
journal = {Cureus},
year = {2026},
month = sep,
doi = {10.7759/cureus.116638},
url = {https://europepmc.org/article/MED/42910198},
note = {CC BY},
}
RIS
TY - JOUR
TI - Rapid Pain Reduction and Wound Closure Following Treatment With an Amorphous Silica-Based Fiber Wound Matrix in Partial-Thickness Thermal Burns: A Case Report.
AU - Adam M Jorgensen
AU - William L Hickerson
PY - 2026
DA - 2026/09/21
JO - Cureus
DO - 10.7759/cureus.116638
UR - https://europepmc.org/article/MED/42910198
AB - Partial-thickness thermal burns can cause substantial pain and require effective wound management to support re-epithelialization. A 30-year-old man sustained 3%-4% total body surface area partial-thickness burns of the left hand, forearm, elbow, and abdomen following a gasoline-accelerated brush fire. Despite emergency debridement, dressings, and multimodal analgesia, pain remained 6-10/10. Approximately two days after injury, an amorphous silica-based fiber (SBF) wound matrix was applied to the open wounds, while a silica-based cream (SBC) was applied to surrounding intact skin. At initial SBF/SBC treatment, patient-reported pain decreased from 7/10 to 0/10 on a 0-10 numerical rating scale (NRS), with substantial relief reported within approximately 5-10 minutes. Across 12 paired assessments, mean pain decreased from 2.46/10 before treatment to 1.17/10 afterward. Serial planimetry demonstrated progressive wound closure with complete measured closure by Day 10, with sustained epithelial coverage and minimal scarring at Day 63. Because partial-thickness burns may spontaneously re-epithelialize, and this represents a single uncontrolled case with prior and concomitant treatment, causality cannot be established. The observed temporal pain response and wound-healing trajectory support prospective controlled evaluation using standardized pain, analgesic-use, epithelialization, functional, and safety endpoints.
SN - 2168-8184
ER -