Topical MSC-Derived Extracellular Vesicles Accelerate Healing of Second-Degree Burns: A Case Report
Abstract
Burn injuries are challenging to treat due to wound progression and long-term scarring. Mesenchymal stem cell (MSC)–derived extracellular vesicles (EVs) have regenerative and immunomodulatory properties that may mitigate these complications. In this phase 1/2a, first-in-human, open-label study, a 48-year-old man with deep second-degree burns received a single topical dose of allogeneic bone marrow MSC-derived EVs within 48 h of injury. The treated wound achieved > 99% closure within 1 week, with durable healing for over 1 year. Scar outcomes improved over 52 weeks, with Patient and Observer Scar Assessment Scale scores indicating early resolution of pain and pruritus and minimal residual scarring. No adverse events occurred. Laser Doppler imaging showed improved perfusion within 1 week, suggesting prevention of burn wound conversion. These findings support the potential of MSC-derived EVs to accelerate burn healing and reduce scar-related morbidity.
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BibTeX
@article{schulman2026topical,
title = {{Topical MSC-Derived Extracellular Vesicles Accelerate Healing of Second-Degree Burns: A Case Report}},
author = {Carl I Schulman and Nicholas Namias and Louis Pizano and Booker T King and Shelley Hartman and Gloria Mathews and Willistine Lenon and Heidi Kempinski and Luis Rodriguez-Menocal and Wellington Guzman and Aaron Sandoval and Evangelos V Badiavas},
journal = {Journal of Burn Care \& Research: Official Publication of the American Burn Association},
year = {2026},
month = aug,
doi = {10.1093/jbcr/irag148},
url = {https://doi.org/10.1093/jbcr/irag148},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Topical MSC-Derived Extracellular Vesicles Accelerate Healing of Second-Degree Burns: A Case Report
AU - Carl I Schulman
AU - Nicholas Namias
AU - Louis Pizano
AU - Booker T King
AU - Shelley Hartman
AU - Gloria Mathews
AU - Willistine Lenon
AU - Heidi Kempinski
AU - Luis Rodriguez-Menocal
AU - Wellington Guzman
AU - Aaron Sandoval
AU - Evangelos V Badiavas
PY - 2026
DA - 2026/08/20
JO - Journal of Burn Care & Research: Official Publication of the American Burn Association
DO - 10.1093/jbcr/irag148
UR - https://doi.org/10.1093/jbcr/irag148
AB - Burn injuries are challenging to treat due to wound progression and long-term scarring. Mesenchymal stem cell (MSC)–derived extracellular vesicles (EVs) have regenerative and immunomodulatory properties that may mitigate these complications. In this phase 1/2a, first-in-human, open-label study, a 48-year-old man with deep second-degree burns received a single topical dose of allogeneic bone marrow MSC-derived EVs within 48 h of injury. The treated wound achieved > 99% closure within 1 week, with durable healing for over 1 year. Scar outcomes improved over 52 weeks, with Patient and Observer Scar Assessment Scale scores indicating early resolution of pain and pruritus and minimal residual scarring. No adverse events occurred. Laser Doppler imaging showed improved perfusion within 1 week, suggesting prevention of burn wound conversion. These findings support the potential of MSC-derived EVs to accelerate burn healing and reduce scar-related morbidity.
SN - 1559-047X
SN - 1559-0488
ER -