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Peer-reviewedLicence not statedNature

Targeting cancer-specific mutations with RNA-triggered chromatin shredding

  • Jingkun Zeng1,2,3,4
  • Zhiyuan Cheng2,3,5
  • Huadong Chen6
  • Zhaojun Wang2,3
  • Jared Thompson7
  • Kadin T. Crosby8
  • Hesong Han4
  • Arushi Singhal2,3
  • Wayne Ngo1,2,3,4
  • Chenglong Xia4
  • Daniel Rosas-Rivera2,3
  • Zeyuan Terry Zhang1,4
13 more authors
  • Min Hyung Kang4
  • Ying Mao6
  • Morgan E. Diolaiti6
  • Giselle C. Lee9
  • John F.X. Diffley9
  • Yixuan Song9
  • Longhui Qiu10
  • Nathan M. Krah7,11
  • Niren Murthy12,4
  • Ryan N. Jackson8
  • Yang Liu7
  • Alan Ashworth6
  • Jennifer A. Doudna13,14,15,16,17,18,19,20,21
21 affiliations
  1. 1California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA
  2. 2Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA
  3. 3Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA
  4. 4Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA
  5. 5School of Biological Science, University of Manchester, Manchester, UK
  6. 6Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA
  7. 7Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA
  8. 8Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA
  9. 9The Francis Crick Institute, London, UK
  10. 10Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
  11. 11Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA
  12. 12Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA
  13. 13California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA. [email protected]
  14. 14Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA. [email protected]
  15. 15Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. [email protected]
  16. 16Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA. [email protected]
  17. 17Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. [email protected]
  18. 18Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA. [email protected]
  19. 19Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. [email protected]
  20. 20Li Ka Shing Center for Genomic Engineering, University of California, Berkeley, Berkeley, CA, USA. [email protected]
  21. 21Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. [email protected]
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{zeng2026targeting,
  title = {{Targeting cancer-specific mutations with RNA-triggered chromatin shredding}},
  author = {Jingkun Zeng and Zhiyuan Cheng and Huadong Chen and Zhaojun Wang and Jared Thompson and Kadin T. Crosby and Hesong Han and Arushi Singhal and Wayne Ngo and Chenglong Xia and Daniel Rosas-Rivera and Zeyuan Terry Zhang and Min Hyung Kang and Ying Mao and Morgan E. Diolaiti and Giselle C. Lee and John F.X. Diffley and Yixuan Song and Longhui Qiu and Nathan M. Krah and Niren Murthy and Ryan N. Jackson and Yang Liu and Alan Ashworth and Jennifer A. Doudna},
  journal = {Nature},
  year = {2026},
  month = jun,
  doi = {10.1038/s41586-026-10738-7},
  url = {https://pmc.ncbi.nlm.nih.gov/articles/PMC13533554/pdf/nihms-2203200.pdf},
}
RIS
TY  - JOUR
TI  - Targeting cancer-specific mutations with RNA-triggered chromatin shredding
AU  - Jingkun Zeng
AU  - Zhiyuan Cheng
AU  - Huadong Chen
AU  - Zhaojun Wang
AU  - Jared Thompson
AU  - Kadin T. Crosby
AU  - Hesong Han
AU  - Arushi Singhal
AU  - Wayne Ngo
AU  - Chenglong Xia
AU  - Daniel Rosas-Rivera
AU  - Zeyuan Terry Zhang
AU  - Min Hyung Kang
AU  - Ying Mao
AU  - Morgan E. Diolaiti
AU  - Giselle C. Lee
AU  - John F.X. Diffley
AU  - Yixuan Song
AU  - Longhui Qiu
AU  - Nathan M. Krah
AU  - Niren Murthy
AU  - Ryan N. Jackson
AU  - Yang Liu
AU  - Alan Ashworth
AU  - Jennifer A. Doudna
PY  - 2026
DA  - 2026/06/08
JO  - Nature
DO  - 10.1038/s41586-026-10738-7
UR  - https://pmc.ncbi.nlm.nih.gov/articles/PMC13533554/pdf/nihms-2203200.pdf
SN  - 0028-0836
SN  - 1476-4687
ER  -