Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 35 min ago
Peer-reviewedCC BY-NC-ND 4.0In Vivo

Prognostic Value of Histology-specific Ki-67 Labeling Index Cutoffs in Stage I-III Non-small Cell Lung Cancer

  • YOHEI KAMEDA1,2
  • TETSUKAN WOO1,3
  • MAI MATSUMURA4
  • TOMOE SAWAZUMI5
  • HIROMASA ARAI6
  • KOJI OKUDELA4
  • AYA SAITO1
6 affiliations
  1. 1Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan
  2. 2Department of Thoracic Surgery, Yokohama Rosai Hospital, Yokohama, Japan
  3. 3Department of Thoracic Surgery, Yokohama City University School of Medicine, Yokohama, Japan
  4. 4Department of Pathology, Saitama Medical University School of Medicine, Saitama, Japan
  5. 5Department of Pathology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan
  6. 6Department of Thoracic Surgery, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan
Read full textPDFDOICite

Abstract

Background/Aim: Although the Ki-67 labeling index (LI) is widely used as a marker of tumor proliferative activity, its prognostic utility in non-small cell lung cancer (NSCLC) remains uncertain because of heterogeneous study populations and the lack of standardized, histology-specific cutoff values.

Patients and Methods: We retrospectively analyzed 1,245 patients with completely resected pathologic stage I-III NSCLC. Time-dependent receiver operating characteristic (ROC) analysis for postoperative recurrence within 5 years was used to determine Ki-67 LI cutoff values. Associations between Ki-67 LI status and recurrence-free survival (RFS) and overall survival (OS) were assessed using Kaplan-Meier analysis and multivariable Cox proportional hazards models.

Results: Ki-67 LI was significantly higher in squamous cell carcinoma than in adenocarcinoma (median, 40.0% vs. 15.0%; p<0.001). Time-dependent ROC analysis yielded a cutoff value of 21.0% for the overall NSCLC cohort and histology-specific cutoff values of 13.0% for adenocarcinoma and 40.5% for squamous cell carcinoma. The corresponding 5-year area under the curves (AUCs) were 0.656 for the overall NSCLC cohort, 0.691 for adenocarcinoma, and 0.607 for squamous cell carcinoma. After multivariable adjustment, high Ki-67 LI was independently associated with poorer RFS in the overall NSCLC cohort [hazard ratio (HR)=1.40; 95% confidence interval (CI)=1.11-1.77; p=0.005], adenocarcinoma cohort (HR=1.57; 95%CI=1.15-2.16; p=0.005), and squamous cell carcinoma cohort (HR=1.82; 95%CI=1.22-2.73; p=0.004). High Ki-67 LI was also independently associated with poorer OS in the overall NSCLC and adenocarcinoma cohorts, but not in the squamous cell carcinoma cohort.

Conclusion: High Ki-67 LI was independently associated with an increased risk of postoperative recurrence in both adenocarcinoma and squamous cell carcinoma. Histology-specific cutoffs derived by time-dependent ROC analysis may support Ki-67-based postoperative risk stratification in resected NSCLC.

Related

  1. A Histology‐Derived Score Integrating Tumor–Stroma Ratio, Tertiary Lymphoid Structures, and Tumor Budding Improves Prognostic Stratification in Colorectal Cancer
    Meng Tian, Jianwei Yuan, Quanquan Hu +1
    Cancer MedicinePeer-reviewedCC BY-NC-ND 4.0Full textOncologyPMC
  2. Development and external clinical validation of a histology-inclusive prognostic nomogram for vulvar cancer based on the Surveillance, Epidemiology, and End Results database.
    Hongqian Ke, Ning Xie, Qian Wu +1
    Translational cancer researchPeer-reviewedCC BY-NC-NDFull textSurgery & anaesthesiaEurope PMC
  3. Development and internal validation of a prognostic model for cancer-specific survival in elderly patients with metastatic non-small cell lung cancer: a SEER-based study
    Journal of thoracic diseasePeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  4. FOXM1 Drives Subtype-Specific Dysregulation of Prognostic miRNAs in Breast Cancer Cells
    Zuhal Hamurcu, Venhar Cınar, Ayse Doga Karipcin +6
    Journal of clinical practice and researchPeer-reviewedCC BY-NCFull textGeneral medicineEurope PMC
  5. Comparative and Histology-Aware Bioinformatic Characterization of FAM171A1 and FAM171A2 in Sarcoma: Expression, Prognostic, and Immune Associations
    Gonul Seyda Seydel, Durmus Ayan
    BiomedicinesPeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{kameda2026prognostic,
  title = {{Prognostic Value of Histology-specific Ki-67 Labeling Index Cutoffs in Stage I-III Non-small Cell Lung Cancer}},
  author = {YOHEI KAMEDA and TETSUKAN WOO and MAI MATSUMURA and TOMOE SAWAZUMI and HIROMASA ARAI and KOJI OKUDELA and AYA SAITO},
  journal = {In Vivo},
  year = {2026},
  month = oct,
  doi = {10.21873/invivo.14514},
  url = {https://doi.org/10.21873/invivo.14514},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Prognostic Value of Histology-specific Ki-67 Labeling Index Cutoffs in Stage I-III Non-small Cell Lung Cancer
AU  - YOHEI KAMEDA
AU  - TETSUKAN WOO
AU  - MAI MATSUMURA
AU  - TOMOE SAWAZUMI
AU  - HIROMASA ARAI
AU  - KOJI OKUDELA
AU  - AYA SAITO
PY  - 2026
DA  - 2026/10/29
JO  - In Vivo
DO  - 10.21873/invivo.14514
UR  - https://doi.org/10.21873/invivo.14514
AB  - Background/Aim: Although the Ki-67 labeling index (LI) is widely used as a marker of tumor proliferative activity, its prognostic utility in non-small cell lung cancer (NSCLC) remains uncertain because of heterogeneous study populations and the lack of standardized, histology-specific cutoff values.  Patients and Methods: We retrospectively analyzed 1,245 patients with completely resected pathologic stage I-III NSCLC. Time-dependent receiver operating characteristic (ROC) analysis for postoperative recurrence within 5 years was used to determine Ki-67 LI cutoff values. Associations between Ki-67 LI status and recurrence-free survival (RFS) and overall survival (OS) were assessed using Kaplan-Meier analysis and multivariable Cox proportional hazards models.  Results: Ki-67 LI was significantly higher in squamous cell carcinoma than in adenocarcinoma (median, 40.0% vs. 15.0%; p<0.001). Time-dependent ROC analysis yielded a cutoff value of 21.0% for the overall NSCLC cohort and histology-specific cutoff values of 13.0% for adenocarcinoma and 40.5% for squamous cell carcinoma. The corresponding 5-year area under the curves (AUCs) were 0.656 for the overall NSCLC cohort, 0.691 for adenocarcinoma, and 0.607 for squamous cell carcinoma. After multivariable adjustment, high Ki-67 LI was independently associated with poorer RFS in the overall NSCLC cohort [hazard ratio (HR)=1.40; 95% confidence interval (CI)=1.11-1.77; p=0.005], adenocarcinoma cohort (HR=1.57; 95%CI=1.15-2.16; p=0.005), and squamous cell carcinoma cohort (HR=1.82; 95%CI=1.22-2.73; p=0.004). High Ki-67 LI was also independently associated with poorer OS in the overall NSCLC and adenocarcinoma cohorts, but not in the squamous cell carcinoma cohort.  Conclusion: High Ki-67 LI was independently associated with an increased risk of postoperative recurrence in both adenocarcinoma and squamous cell carcinoma. Histology-specific cutoffs derived by time-dependent ROC analysis may support Ki-67-based postoperative risk stratification in resected NSCLC.
SN  - 0258-851X
SN  - 1791-7549
ER  -