Chronic Kidney Disease with Sjögren’s Syndrome and Hyperthyroidism: Discrepant Creatinine- and Cystatin C-Based eGFR
Abstract
We report the case of a 70-year-old woman with chronic kidney disease, hyperthyroidism, and Sjögren's syndrome who exhibited a marked discrepancy between creatinine-based and cystatin C-based estimated glomerular filtration rates(eGFRs). A kidney biopsy revealed chronic tubulointerstitial nephritis with lymphoplasmacytic infiltration, and electron microscopy showed focal subendothelial widening without electron-dense deposits. Methimazole improved the thyroid function and reduced discrepancies between eGFR estimates. Proteinuria and tubular injury markers improved after corticosteroid therapy. A correction of dehydration and an improvement in the nutritional status may also have influenced the clinical outcomes. These findings highlight the need to consider thyroid dysfunction when interpreting the renal biomarker levels.
Related
- Association of the sarcopenia index based on the serum creatinine to cystatin C ratio and genetic risk with venous thromboembolism: a population-based cohort study
- Study variation in estimating Glomerular Filtration Rate (GFR) from serum creatinine, cystatin C, age, and sex
- Comparative risk assessment of cardiovascular and kidney outcomes in patients with type 2 diabetes using cystatin C and creatinine in DECLARE-TIMI 58
- Plasma Cystatin C as a Marker of Acute-on-Chronic Liver Failure and 28-Day Mortality in Patients With Acutely Decompensated Liver Cirrhosis: A Prospective Observational Study
- Reversible Cerebral Vasoconstriction Syndrome with Hyperthyroidism
BibTeX
@article{mizuta2026chronic,
title = {{Chronic Kidney Disease with Sjögren’s Syndrome and Hyperthyroidism: Discrepant Creatinine- and Cystatin C-Based eGFR}},
author = {Masato Mizuta and Makoto Fukuda and Mako Fujii and Hikaru Fukamura and Yuki Ikeda and Akiko Kanaya and Maki Yoshihara and Shigehisa Aoki and Motoaki Miyazono},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.7902-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7902-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Chronic Kidney Disease with Sjögren’s Syndrome and Hyperthyroidism: Discrepant Creatinine- and Cystatin C-Based eGFR
AU - Masato Mizuta
AU - Makoto Fukuda
AU - Mako Fujii
AU - Hikaru Fukamura
AU - Yuki Ikeda
AU - Akiko Kanaya
AU - Maki Yoshihara
AU - Shigehisa Aoki
AU - Motoaki Miyazono
PY - 2026
DA - 2026/08/25
JO - Internal Medicine
DO - 10.2169/internalmedicine.7902-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7902-26/_article
AB - We report the case of a 70-year-old woman with chronic kidney disease, hyperthyroidism, and Sjögren's syndrome who exhibited a marked discrepancy between creatinine-based and cystatin C-based estimated glomerular filtration rates(eGFRs). A kidney biopsy revealed chronic tubulointerstitial nephritis with lymphoplasmacytic infiltration, and electron microscopy showed focal subendothelial widening without electron-dense deposits. Methimazole improved the thyroid function and reduced discrepancies between eGFR estimates. Proteinuria and tubular injury markers improved after corticosteroid therapy. A correction of dehydration and an improvement in the nutritional status may also have influenced the clinical outcomes. These findings highlight the need to consider thyroid dysfunction when interpreting the renal biomarker levels.
SN - 1349-7235
SN - 0918-2918
ER -