Rituximab-induced Acute Thrombocytopenia in Systemic Sclerosis: A Case Report of Two Cases

Abstract

Rituximab is frequently used to treat hematological and autoimmune diseases. Rituximab-induced acute thrombocytopenia (RIAT) is a rare adverse event associated with the use of this drug. In this report, we describe two cases of RIAT in patients with systemic sclerosis. Severe thrombocytopenia was observed in both patients following the second rituximab infusion. In addition, mild leukopenia, hypocomplementemia, and systemic inflammation were observed. Most previous reports have described RIAT in patients with hematological malignancies, but patients with autoimmune diseases may also develop this condition.

Systemic Sclerosis Presenting With Long-Standing Peripheral Neuropathy and Delayed Multisystem Manifestations: A Case Report
Bhargavan PV, Sila Chandran, Aswin US +2
Cureus16 Oct 2026Peer-reviewedCC BYFull textGeneral medicineEurope PMC
Case Report: Value of MR relaxometry and spectroscopy in multimodal imaging characterization of limbic encephalitis in systemic sclerosis
Florian Awin Stolz, Andrei Manzhurtsev, Marlene Bönstrup +5
Frontiers in radiology16 Oct 2026Peer-reviewedCC BYFull textMedical imaging & radiologyEurope PMC
Interpreting long‐term response to rituximab in immune thrombocytopenia: Cohort construction, treatment attribution, and dynamic prognostication
Xin Zhou, Ningning Shan
HemaSphere29 Oct 2026Peer-reviewedCC BYFull textEndocrinology & metabolismDOAJ
Scleroderma Renal Crisis-Associated Thrombotic Microangiopathy Preceding Skin Sclerosis in Diffuse Cutaneous Systemic Sclerosis: A Case Report
Tomoki Kobayashi, Ken Goda, Kodai Yamamoto +5
Internal Medicine29 Sep 2026Peer-reviewedCC BY-NC-NDFull textGeneral medicineJ-STAGE
Case Report: Upfront sotatercept-based triple therapy in high-risk systemic sclerosis-associated pulmonary arterial hypertension
Yuichi Tamura, Sarasa Isobe, Hiroyuki Fujii +2
Frontiers in Cardiovascular Medicine7 Oct 2026Peer-reviewedCC BY 4.0Full textCardiovascular medicineCrossrefEurope PMC

Cite

BibTeX RIS

BibTeX

@article{saiki2026rituximabinduced,
  title = {{Rituximab-induced Acute Thrombocytopenia in Systemic Sclerosis: A Case Report of Two Cases}},
  author = {Chihiro Saiki and Masahiro Ayano and Yuki Kojima and Atsushi Naito and Naoyasu Ueda and Hiroaki Niiro},
  journal = {Internal Medicine},
  year = {2026},
  month = aug,
  doi = {10.2169/internalmedicine.6630-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/16/65_6630-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Rituximab-induced Acute Thrombocytopenia in Systemic Sclerosis: A Case Report of Two Cases
AU  - Chihiro Saiki
AU  - Masahiro Ayano
AU  - Yuki Kojima
AU  - Atsushi Naito
AU  - Naoyasu Ueda
AU  - Hiroaki Niiro
PY  - 2026
DA  - 2026/08/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6630-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/16/65_6630-25/_article
AB  - Rituximab is frequently used to treat hematological and autoimmune diseases. Rituximab-induced acute thrombocytopenia (RIAT) is a rare adverse event associated with the use of this drug. In this report, we describe two cases of RIAT in patients with systemic sclerosis. Severe thrombocytopenia was observed in both patients following the second rituximab infusion. In addition, mild leukopenia, hypocomplementemia, and systemic inflammation were observed. Most previous reports have described RIAT in patients with hematological malignancies, but patients with autoimmune diseases may also develop this condition.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

Related

Cite