Peer-reviewedCC BY-NC-NDInternal Medicine
Late Recurrence of Gastric Signet-Ring Cell Carcinoma Presenting as Pulmonary Metastasis 18 Years after Gastrectomy: A Case Report and Literature Review
Abstract
A 77-year-old woman presented with anorexia and weight loss. Chest computed tomography revealed a pulmonary mass and diffuse ground-glass opacity. She had undergone gastrectomy for gastric signet-ring cell carcinoma 18 years previously. A biopsy revealed poorly differentiated adenocarcinoma with signet ring cells. Treatment was initiated after the diagnosis of primary lung cancer. A temporary response was achieved; however, the patient died eight months later. Subsequent immunohistochemical findings were similar to the pathological findings obtained 18 years earlier, thus indicating gastric cancer recurrence. This case highlights the possibility of a late recurrence after surgery for gastric cancer.
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BibTeX
@article{setoguchi2026late,
title = {{Late Recurrence of Gastric Signet-Ring Cell Carcinoma Presenting as Pulmonary Metastasis 18 Years after Gastrectomy: A Case Report and Literature Review}},
author = {Daichi Setoguchi and Shinnosuke Takemoto and Kouki Yamashita and Akisato Itagaki and Iwanaga Shintaro and Akagi Kazumasa and Shougo Yamamoto and Dotsu Yosuke and Hirokazu Taniguchi and Yuji Ito and Hiroshi Mukae},
journal = {Internal Medicine},
year = {2026},
month = sep,
doi = {10.2169/internalmedicine.7978-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7978-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Late Recurrence of Gastric Signet-Ring Cell Carcinoma Presenting as Pulmonary Metastasis 18 Years after Gastrectomy: A Case Report and Literature Review
AU - Daichi Setoguchi
AU - Shinnosuke Takemoto
AU - Kouki Yamashita
AU - Akisato Itagaki
AU - Iwanaga Shintaro
AU - Akagi Kazumasa
AU - Shougo Yamamoto
AU - Dotsu Yosuke
AU - Hirokazu Taniguchi
AU - Yuji Ito
AU - Hiroshi Mukae
PY - 2026
DA - 2026/09/01
JO - Internal Medicine
DO - 10.2169/internalmedicine.7978-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7978-26/_article
AB - A 77-year-old woman presented with anorexia and weight loss. Chest computed tomography revealed a pulmonary mass and diffuse ground-glass opacity. She had undergone gastrectomy for gastric signet-ring cell carcinoma 18 years previously. A biopsy revealed poorly differentiated adenocarcinoma with signet ring cells. Treatment was initiated after the diagnosis of primary lung cancer. A temporary response was achieved; however, the patient died eight months later. Subsequent immunohistochemical findings were similar to the pathological findings obtained 18 years earlier, thus indicating gastric cancer recurrence. This case highlights the possibility of a late recurrence after surgery for gastric cancer.
SN - 1349-7235
SN - 0918-2918
ER -