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Peer-reviewedCC BY 4.0Cureus

Beyond the Tumor: A Rare Paraneoplastic Combination Unmasking Lung Cancer

  • Mariame Jaouhari1,2
  • Hanane Ikrou1,2
  • Oussama Halloumi1,2
  • Hind Serhane1
  1. 1Department of Pulmonology, Mohamed VI University Hospital of Agadir, Agadir, MAR
  2. 2LARISS Laboratory, Faculty of Medicine and Pharmacy of Agadir, Ibn Zohr University, Agadir, MAR
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Abstract

Paraneoplastic syndromes are heterogeneous clinical manifestations that may occasionally reveal an underlying malignancy. We report the case of a 37-year-old man with lung adenocarcinoma who presented with severe hypotonic hyponatremia suggestive of syndrome of inappropriate antidiuretic hormone secretion (SIADH), recurrent hypoglycemia, and an isolated prolonged activated partial thromboplastin time (aPTT), in whom a paraneoplastic origin of these abnormalities was suspected. This uncommon coexistence highlights the importance of considering an occult malignancy in patients presenting with multiple unexplained endocrine and coagulation abnormalities. It also illustrates the challenges of interpreting an isolated prolonged aPTT and the need for a systematic diagnostic evaluation of each abnormality before attributing it to a paraneoplastic mechanism.

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Cite

BibTeXRIS
BibTeX
@article{jaouhari2026beyond,
  title = {{Beyond the Tumor: A Rare Paraneoplastic Combination Unmasking Lung Cancer}},
  author = {Mariame Jaouhari and Hanane Ikrou and Oussama Halloumi and Hind Serhane},
  journal = {Cureus},
  year = {2026},
  month = oct,
  doi = {10.7759/cureus.117588},
  url = {https://doi.org/10.7759/cureus.117588},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Beyond the Tumor: A Rare Paraneoplastic Combination Unmasking Lung Cancer
AU  - Mariame Jaouhari
AU  - Hanane Ikrou
AU  - Oussama Halloumi
AU  - Hind Serhane
PY  - 2026
DA  - 2026/10/07
JO  - Cureus
DO  - 10.7759/cureus.117588
UR  - https://doi.org/10.7759/cureus.117588
AB  - Paraneoplastic syndromes are heterogeneous clinical manifestations that may occasionally reveal an underlying malignancy. We report the case of a 37-year-old man with lung adenocarcinoma who presented with severe hypotonic hyponatremia suggestive of syndrome of inappropriate antidiuretic hormone secretion (SIADH), recurrent hypoglycemia, and an isolated prolonged activated partial thromboplastin time (aPTT), in whom a paraneoplastic origin of these abnormalities was suspected. This uncommon coexistence highlights the importance of considering an occult malignancy in patients presenting with multiple unexplained endocrine and coagulation abnormalities. It also illustrates the challenges of interpreting an isolated prolonged aPTT and the need for a systematic diagnostic evaluation of each abnormality before attributing it to a paraneoplastic mechanism.
SN  - 2168-8184
ER  -