Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 20 min ago
Peer-reviewedCC BY-NC-NDNutrition journal

Total and beverage-specific alcohol use at mid-life and all-cause and cause-specific mortality: a prospective cohort study.

  • Ziyue Li1,2,3
  • Bohao Tan1,2,3
  • Clémence Desjardins4
  • Lu Wang5
  • Neha Khandpur6
  • Yu Feng1,2,3
  • Hannah Oh7
  • Qirui Li1
  • Frank Qian8
  • Geng Zong9
  • Shenghua Zhou1,3
  • Trudy Voortman10,11
1 more authors
  • Zhangling Chen12,13,14,15
15 affiliations
  1. 1Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  2. 2FuRong Laboratory, Changsha, Hunan, China.
  3. 3Key Laboratory of Cardiometabolic Medicine in Hunan Province, Changsha, Hunan, China.
  4. 4Centre Nutrition, Santé et Société (NUTRISS), Institut sur la Nutrition et les Aliments Fonctionnels (INAF), Université Laval, Québec City, Canada.
  5. 5Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
  6. 6Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands.
  7. 7Interdisciplinary Program in Precision Public Health, Department of Public Health Sciences, Graduate School of Korea University, Seoul, Republic of Korea.
  8. 8Section of Cardiovascular Medicine, Boston Medical Center and Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
  9. 9CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai, China.
  10. 10Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  11. 11Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, US.
  12. 12Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. [email protected].
  13. 13FuRong Laboratory, Changsha, Hunan, China. [email protected].
  14. 14Key Laboratory of Cardiometabolic Medicine in Hunan Province, Changsha, Hunan, China. [email protected].
  15. 15Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. [email protected].
Read full textPDFDOICite

Abstract

Background

While detrimental health impacts of excessive alcohol use are well-established, potential effects of low-to-moderate drinking remain controversial. We examined the associations between total and beverage-specific alcohol intake and mortality, including cardiovascular disease (CVD), cancer (e.g., 20 site-specific cancers), and other mortality.Methods

We included 340,924 participants from UK Biobank (2006-2022). Alcohol use was categorized as: never or occasional alcohol consumption (≤ 20 g/week), low consumption (> 20 g/week to ≤ 20 g/d for men, > 20 g/week to ≤ 10 g/d for women), moderate consumption (> 20 to ≤ 40 g/d for men, > 10 to ≤ 20 g/d for women), and high consumption (> 40 g/d for men and > 20 g/d for women). We used Cox proportional hazard models to examine the associations of alcohol intake and mortality.Results

During a mean follow-up of 13.4 years, we documented 22,381 deaths. Compared with never or occasional alcohol intake, high total alcohol intake was associated with higher mortality from all-causes (HR and 95%CI: 1.24 (1.17, 1.31)), CVD (1.14 (1.01, 1.28)), cancer (1.36 (1.26, 1.47)), and other causes (1.12 (1.02, 1.22)), whereas moderate alcohol use was associated with higher cancer mortality (1.11 (1.03, 1.20)) only. Alcohol consumption from spirits and beer/cider, even at low to moderate levels, was associated with higher mortality from all-causes, CVD, cancer, and other diseases (HRs ranging from 1.07 to 1.83). Yet, low and moderate alcohol intake from wine was associated with lower all-cause, CVD, cancer, or other mortality. Importantly, moderate to high intake of total alcohol and alcohol from beer/cider and spirits, and high wine use were particularly associated with higher mortality from multiple site-specific cancers, including mortality from head/neck, respiratory system, gastrointestinal, liver/gallbladder, hematological, female breast, and female/male genital cancers.Conclusions

The results suggested that low to moderate alcohol intake from spirits and beer/cider was associated with higher all-cause, CVD, cancer, and other mortality, whereas low to moderate alcohol use from wine was associated with lower all-cause, CVD, cancer, and other mortality. However, high alcohol use, regardless of beverage-type, mortality from various site-specific cancers was elevated.

Related

  1. Association Between Sugar‐Sweetened Beverage Consumption and All‐Cause Mortality in Individuals With and Without Metabolic Syndrome: A Prospective Cohort Study
    Tingting Lv, Xintian Ren, Yanfang Tan +1
    Health Science ReportsPeer-reviewedCC BY 4.0Full textEndocrinology & metabolismPMCEurope PMCDOAJ
  2. Wrist-worn accelerometer-derived activity fragmentation and cause-specific mortality in US adults: a population-based prospective cohort study
    Jie Li, Xiubo Sun, Jing Zhang +2
    BMC Public HealthPeer-reviewedCC BY-NC-ND 4.0PhysiologyCrossref
  3. Cytomegalovirus Viremia Is Strongly Associated With 6-Month Mortality Among Adults Living With Advanced HIV Disease: A Prospective Cohort Study in South Africa
    Open forum infectious diseasesPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. The cardiovascular–liver–metabolic syndemic and mortality and life expectancy: two prospective cohort studies
    Jiaxiang Wang, Cheng Zu, Yongfu Yu +3
    BMC MedicinePeer-reviewedCC BY-NC-ND 4.0Endocrinology & metabolismCrossref
  5. Night-to-night sleep variability and all-cause and cardiovascular mortality: a prospective cohort study with a complementary in vitro circadian-disruption experiment
    Jing Bai, Peng Chen, Chao Cui +1
    Frontiers in medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{li2026total,
  title = {{Total and beverage-specific alcohol use at mid-life and all-cause and cause-specific mortality: a prospective cohort study.}},
  author = {Ziyue Li and Bohao Tan and Clémence Desjardins and Lu Wang and Neha Khandpur and Yu Feng and Hannah Oh and Qirui Li and Frank Qian and Geng Zong and Shenghua Zhou and Trudy Voortman and Zhangling Chen},
  journal = {Nutrition journal},
  year = {2026},
  month = jul,
  doi = {10.1186/s12937-026-01361-3},
  url = {https://europepmc.org/article/MED/42902373},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Total and beverage-specific alcohol use at mid-life and all-cause and cause-specific mortality: a prospective cohort study.
AU  - Ziyue Li
AU  - Bohao Tan
AU  - Clémence Desjardins
AU  - Lu Wang
AU  - Neha Khandpur
AU  - Yu Feng
AU  - Hannah Oh
AU  - Qirui Li
AU  - Frank Qian
AU  - Geng Zong
AU  - Shenghua Zhou
AU  - Trudy Voortman
AU  - Zhangling Chen
PY  - 2026
DA  - 2026/07/01
JO  - Nutrition journal
DO  - 10.1186/s12937-026-01361-3
UR  - https://europepmc.org/article/MED/42902373
AB  - Background  While detrimental health impacts of excessive alcohol use are well-established, potential effects of low-to-moderate drinking remain controversial. We examined the associations between total and beverage-specific alcohol intake and mortality, including cardiovascular disease (CVD), cancer (e.g., 20 site-specific cancers), and other mortality.Methods  We included 340,924 participants from UK Biobank (2006-2022). Alcohol use was categorized as: never or occasional alcohol consumption (≤ 20 g/week), low consumption (> 20 g/week to ≤ 20 g/d for men, > 20 g/week to ≤ 10 g/d for women), moderate consumption (> 20 to ≤ 40 g/d for men, > 10 to ≤ 20 g/d for women), and high consumption (> 40 g/d for men and > 20 g/d for women). We used Cox proportional hazard models to examine the associations of alcohol intake and mortality.Results  During a mean follow-up of 13.4 years, we documented 22,381 deaths. Compared with never or occasional alcohol intake, high total alcohol intake was associated with higher mortality from all-causes (HR and 95%CI: 1.24 (1.17, 1.31)), CVD (1.14 (1.01, 1.28)), cancer (1.36 (1.26, 1.47)), and other causes (1.12 (1.02, 1.22)), whereas moderate alcohol use was associated with higher cancer mortality (1.11 (1.03, 1.20)) only. Alcohol consumption from spirits and beer/cider, even at low to moderate levels, was associated with higher mortality from all-causes, CVD, cancer, and other diseases (HRs ranging from 1.07 to 1.83). Yet, low and moderate alcohol intake from wine was associated with lower all-cause, CVD, cancer, or other mortality. Importantly, moderate to high intake of total alcohol and alcohol from beer/cider and spirits, and high wine use were particularly associated with higher mortality from multiple site-specific cancers, including mortality from head/neck, respiratory system, gastrointestinal, liver/gallbladder, hematological, female breast, and female/male genital cancers.Conclusions  The results suggested that low to moderate alcohol intake from spirits and beer/cider was associated with higher all-cause, CVD, cancer, and other mortality, whereas low to moderate alcohol use from wine was associated with lower all-cause, CVD, cancer, and other mortality. However, high alcohol use, regardless of beverage-type, mortality from various site-specific cancers was elevated.
SN  - 1475-2891
ER  -