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Peer-reviewedCC BY 4.0The Journal of Physiological Sciences : JPS

An open-source platform for measuring optomotor responses in mice

  • Naofumi Suematsu1
  • Toshihide Ikeda2
  • Takanori Aoki1,2
  • Moe Asayama1,2
  • Takuro Horii3
  • Atsushi Hoshino4
  • Hiroshi Tanaka2
  • Shogo Soma1
4 affiliations
  1. 1Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan
  2. 2Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan
  3. 3Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, 371-8512, Japan
  4. 4Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan
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Abstract

The optomotor response (OMR) is a valuable behavioral index for assessing visual function in basic research; however, commercially available OMR evaluation equipment is expensive and lacks flexibility, as proprietary software and fixed hardware geometry restrict custom stimulus protocols and system modifications. Alternative low-cost, non-OMR methods often require extensive animal pre-training and are unsuitable for high-throughput studies. To overcome these limitations, we developed a low-cost, open-source OMR recording system for mice that lowers both financial and practical barriers, thereby facilitating widespread adoption across laboratories. Following a one-hour training session for evaluators, the system enabled precise quantification of visual acuity and assessment of contrast sensitivity in normal-sighted mice, detection of age-related visual decline, and evaluation of OMR extinction in retinitis pigmentosa model mice. This system facilitates accessible and efficient assessment of visual function in vision research.

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Cite

BibTeXRIS
BibTeX
@article{suematsu2026opensource,
  title = {{An open-source platform for measuring optomotor responses in mice}},
  author = {Naofumi Suematsu and Toshihide Ikeda and Takanori Aoki and Moe Asayama and Takuro Horii and Atsushi Hoshino and Hiroshi Tanaka and Shogo Soma},
  journal = {The Journal of Physiological Sciences : JPS},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jphyss.2026.100113},
  url = {https://doi.org/10.1016/j.jphyss.2026.100113},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - An open-source platform for measuring optomotor responses in mice
AU  - Naofumi Suematsu
AU  - Toshihide Ikeda
AU  - Takanori Aoki
AU  - Moe Asayama
AU  - Takuro Horii
AU  - Atsushi Hoshino
AU  - Hiroshi Tanaka
AU  - Shogo Soma
PY  - 2026
DA  - 2026/10/23
JO  - The Journal of Physiological Sciences : JPS
DO  - 10.1016/j.jphyss.2026.100113
UR  - https://doi.org/10.1016/j.jphyss.2026.100113
AB  - The optomotor response (OMR) is a valuable behavioral index for assessing visual function in basic research; however, commercially available OMR evaluation equipment is expensive and lacks flexibility, as proprietary software and fixed hardware geometry restrict custom stimulus protocols and system modifications. Alternative low-cost, non-OMR methods often require extensive animal pre-training and are unsuitable for high-throughput studies. To overcome these limitations, we developed a low-cost, open-source OMR recording system for mice that lowers both financial and practical barriers, thereby facilitating widespread adoption across laboratories. Following a one-hour training session for evaluators, the system enabled precise quantification of visual acuity and assessment of contrast sensitivity in normal-sighted mice, detection of age-related visual decline, and evaluation of OMR extinction in retinitis pigmentosa model mice. This system facilitates accessible and efficient assessment of visual function in vision research.
SN  - 1880-6546
SN  - 1880-6562
ER  -