Incidence and prevalence of hidradenitis suppurativa across spondyloarthritis-related diseases: cohort study using electronic health records
9 affiliations
- 1Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom.
- 2Department of Rheumatology, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
- 3Department of Medicine, University Hospital Aintree, University Hospitals of Liverpool Group, Liverpool, United Kingdom.
- 4Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
- 5Department of General Surgery (Coloproctology), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
- 6Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
- 7Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
- 8Centre for Dermatology Research, Salford Royal NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, The University of Manchester, Manchester, United Kingdom.
- 9Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Abstract
Objective: To describe the recorded prevalence and incidence of HS across pathologically related diseases within the spondyloarthritis (SpA) family, namely psoriatic arthritis (PsA), psoriasis, axial spondyloarthritis (axSpA), uveitis, Crohn’s disease, ulcerative colitis, and, for context, rheumatoid arthritis (RA).
Methods: We conducted a retrospective cohort study using electronic health records data between June 2006 and June 2026. ICD codes were used to define populations of SpA-related diseases and RA. We estimated recorded baseline prevalence and crude incidence of HS, then separately performed 1:1 propensity-score matched comparisons of each disease with healthcare controls, matching for age, sex, BMI and comorbidities.
Results: The disease populations ranged from 55,407 to 429,647 individuals. Recorded HS prevalence was highest in psoriasis (0.65%), PsA (0.52%) and Crohn’s disease (0.47%). Crude incidence was highest in Crohn’s (187.4 per 100,000 person-years) and PsA (134.1 per 100,000 person-years). After matching, incidence was higher than in controls for PsA (incidence rate ratio [IRR] 1.63, 95% CI 1.41-1.88), Crohn’s disease (2.02, 1.85-2.20), and ulcerative colitis (1.17, 1.04-1.32). Incidence was lower than controls in axSpA and RA.
Conclusions: This study highlights a significant epidemiological association between HS and PsA and Crohn’s disease. Clinicians providing care to these patient groups should consider enquiring about HS symptoms, although overall incidence rates are low. Further research is needed into the shared pathophysiology of HS and psoriatic disease.
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BibTeX
@article{zhao2026incidence,
title = {{Incidence and prevalence of hidradenitis suppurativa across spondyloarthritis-related diseases: cohort study using electronic health records}},
author = {Sizheng Steven Zhao and Qingfan Yang and Zhimin Liu and Zenas Yiu and Uazman Alam},
journal = {Frontiers in Immunology},
year = {2026},
month = oct,
doi = {10.3389/fimmu.2026.1945638},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1945638/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Incidence and prevalence of hidradenitis suppurativa across spondyloarthritis-related diseases: cohort study using electronic health records
AU - Sizheng Steven Zhao
AU - Qingfan Yang
AU - Zhimin Liu
AU - Zenas Yiu
AU - Uazman Alam
PY - 2026
DA - 2026/10/13
JO - Frontiers in Immunology
DO - 10.3389/fimmu.2026.1945638
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1945638/full
AB - Objective: To describe the recorded prevalence and incidence of HS across pathologically related diseases within the spondyloarthritis (SpA) family, namely psoriatic arthritis (PsA), psoriasis, axial spondyloarthritis (axSpA), uveitis, Crohn’s disease, ulcerative colitis, and, for context, rheumatoid arthritis (RA). Methods: We conducted a retrospective cohort study using electronic health records data between June 2006 and June 2026. ICD codes were used to define populations of SpA-related diseases and RA. We estimated recorded baseline prevalence and crude incidence of HS, then separately performed 1:1 propensity-score matched comparisons of each disease with healthcare controls, matching for age, sex, BMI and comorbidities. Results: The disease populations ranged from 55,407 to 429,647 individuals. Recorded HS prevalence was highest in psoriasis (0.65%), PsA (0.52%) and Crohn’s disease (0.47%). Crude incidence was highest in Crohn’s (187.4 per 100,000 person-years) and PsA (134.1 per 100,000 person-years). After matching, incidence was higher than in controls for PsA (incidence rate ratio [IRR] 1.63, 95% CI 1.41-1.88), Crohn’s disease (2.02, 1.85-2.20), and ulcerative colitis (1.17, 1.04-1.32). Incidence was lower than controls in axSpA and RA. Conclusions: This study highlights a significant epidemiological association between HS and PsA and Crohn’s disease. Clinicians providing care to these patient groups should consider enquiring about HS symptoms, although overall incidence rates are low. Further research is needed into the shared pathophysiology of HS and psoriatic disease.
SN - 1664-3224
ER -