CypA is a molecular barrier to HIV emergence from Eastern chimpanzees

Abstract

Of the two lineages of lentivirus that endemically infect chimpanzees, only one has served as a source of infections in hu-mans. Using HIV-CRISPR screening, we identify factors that limit the replication of lentivirus from Eastern chimpanzees. We find that CypA restricts nonzoonotic Eastern chimpanzee lentivirus due to a unique feature encoded in capsid. The ability of CypA to restrict lentivirus replication is surprising given that CypA is a host factor exploited by HIV to promote its replica-tion. The selective ability of CypA to restrict this virus provides a molecular explanation as to why lentivirus from Eastern Chimpanzees has never been observed to infect humans. Our work has important implications for understanding the origins of HIV-1 and the potential for novel zoonosis of primate lentiviruses.

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BibTeX RIS

BibTeX

@misc{young2026cypa,
  title = {{CypA is a molecular barrier to HIV emergence from Eastern chimpanzees}},
  author = {M. J. Young and F. Cotera and C. C. C. Gill and J. A. Lewis and F. G. Whitby and A. Abdellatif and J. L. Rocha and M. Singer and M. A. Nalls and F. Faghri and P. H. Sudmant and O. Pornillos and M. Ohainle},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.08.747897},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.08.747897v1},
  note = {CC BY-NC-ND},
}

RIS

TY  - UNPB
TI  - CypA is a molecular barrier to HIV emergence from Eastern chimpanzees
AU  - M. J. Young
AU  - F. Cotera
AU  - C. C. C. Gill
AU  - J. A. Lewis
AU  - F. G. Whitby
AU  - A. Abdellatif
AU  - J. L. Rocha
AU  - M. Singer
AU  - M. A. Nalls
AU  - F. Faghri
AU  - P. H. Sudmant
AU  - O. Pornillos
AU  - M. Ohainle
PY  - 2026
DA  - 2026/09/08
PB  - bioRxiv
DO  - 10.64898/2026.09.08.747897
UR  - https://www.biorxiv.org/content/10.64898/2026.09.08.747897v1
AB  - Of the two lineages of lentivirus that endemically infect chimpanzees, only one has served as a source of infections in hu-mans. Using HIV-CRISPR screening, we identify factors that limit the replication of lentivirus from Eastern chimpanzees. We find that CypA restricts nonzoonotic Eastern chimpanzee lentivirus due to a unique feature encoded in capsid. The ability of CypA to restrict lentivirus replication is surprising given that CypA is a host factor exploited by HIV to promote its replica-tion. The selective ability of CypA to restrict this virus provides a molecular explanation as to why lentivirus from Eastern Chimpanzees has never been observed to infect humans. Our work has important implications for understanding the origins of HIV-1 and the potential for novel zoonosis of primate lentiviruses.
ER  -

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