Posttraumatic stress disorder 2 months after induced vaginal delivery: A multicenter prospective study
Abstract
Objectives: An increased risk of postpartum posttraumatic stress disorder (PTSD) has been reported in women who had labor induced. Knowledge of childbirth-related PTSD in this context remain poorly documented. Our aim was to assess the PTSD prevalence and identify characteristics associated with it after induced vaginal delivery at or near term.
Methods: This was an ancillary cohort study of the Tranexamic Acid for Preventing Postpartum Hemorrhage Following a Vaginal Delivery (TRAAP) randomized controlled trial conducted in 15 French university hospitals in 2015-2016. We included women with induced labor followed by a singleton vaginal delivery after 35 weeks. The main outcome was PTSD profile assessed 2 months after childbirth by two self-administered screening questionnaires (Impact of Event Scale-Revised [IES-R] and the Traumatic Event Scale [TES]). Corrected prevalence of PTSD was estimated using inverse probability weighting for nonresponse. Associations with potential risk factors were assessed with multivariate logistic regression.
Results: Among the 3891 women in the TRAAP trial, 794/3891 (20.4%) had labor induced. Among 560/794 respondents (70.5%), the corrected prevalence of PTSD profile was 10.6% (95% confidence interval [CI] 8.1-13.7). Characteristics associated with a higher risk were psychosocial vulnerability factors (maternal birth in Africa and psychiatric history) and obstetric factors, including characteristics related to the labor induction (cervical ripening adjusted odds ratio [aOR], 2.0; 95% CI 1.1-3.6 and induction for fetal indication aOR, 2.6; 95% CI, 1.2-5.5), postpartum hemorrhage (PPH) ≥1000 mL (aOR, 4.9; 95% CI, 1.8-13.3), and bad memories of delivery at day 2 postpartum (aOR, 3.6; 95% CI, 1.5-10.3).
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BibTeX
@article{froeliger2026posttraumatic,
title = {{Posttraumatic stress disorder 2 months after induced vaginal delivery: A multicenter prospective study}},
author = {Alizée Froeliger and Catherine Deneux‐tharaux and Lola Loussert and Anne Laure Sutter‐dallay and Hugo Madar and Loïc Sentilhes},
journal = {International Journal of Gynecology and Obstetrics},
year = {2026},
month = sep,
doi = {10.1002/ijgo.71329},
url = {https://hal.science/hal-05801751v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Posttraumatic stress disorder 2 months after induced vaginal delivery: A multicenter prospective study
AU - Alizée Froeliger
AU - Catherine Deneux‐tharaux
AU - Lola Loussert
AU - Anne Laure Sutter‐dallay
AU - Hugo Madar
AU - Loïc Sentilhes
PY - 2026
DA - 2026/09/11
JO - International Journal of Gynecology and Obstetrics
DO - 10.1002/ijgo.71329
UR - https://hal.science/hal-05801751v1
AB - Objectives: An increased risk of postpartum posttraumatic stress disorder (PTSD) has been reported in women who had labor induced. Knowledge of childbirth-related PTSD in this context remain poorly documented. Our aim was to assess the PTSD prevalence and identify characteristics associated with it after induced vaginal delivery at or near term. Methods: This was an ancillary cohort study of the Tranexamic Acid for Preventing Postpartum Hemorrhage Following a Vaginal Delivery (TRAAP) randomized controlled trial conducted in 15 French university hospitals in 2015-2016. We included women with induced labor followed by a singleton vaginal delivery after 35 weeks. The main outcome was PTSD profile assessed 2 months after childbirth by two self-administered screening questionnaires (Impact of Event Scale-Revised [IES-R] and the Traumatic Event Scale [TES]). Corrected prevalence of PTSD was estimated using inverse probability weighting for nonresponse. Associations with potential risk factors were assessed with multivariate logistic regression. Results: Among the 3891 women in the TRAAP trial, 794/3891 (20.4%) had labor induced. Among 560/794 respondents (70.5%), the corrected prevalence of PTSD profile was 10.6% (95% confidence interval [CI] 8.1-13.7). Characteristics associated with a higher risk were psychosocial vulnerability factors (maternal birth in Africa and psychiatric history) and obstetric factors, including characteristics related to the labor induction (cervical ripening adjusted odds ratio [aOR], 2.0; 95% CI 1.1-3.6 and induction for fetal indication aOR, 2.6; 95% CI, 1.2-5.5), postpartum hemorrhage (PPH) ≥1000 mL (aOR, 4.9; 95% CI, 1.8-13.3), and bad memories of delivery at day 2 postpartum (aOR, 3.6; 95% CI, 1.5-10.3).
SN - 0020-7292
ER -