Advances in Research on the Genotype–Phenotype Correspondence of Antibiotic Resistance in Helicobacter pylori and Its Molecular Mechanisms: A Narrative Review
4 affiliations
- 1Department of Gastroenterology West China Longquan Hospital Sichuan University/The First People′s Hospital of Longquanyi District Chengdu Chengdu Sichuan China
- 2Department of Laboratory Medicine West China Longquan Hospital Sichuan University/The First People′s Hospital of Longquanyi District Chengdu Chengdu Sichuan China
- 3Department of Endoscopy Center West China Longquan Hospital Sichuan University/The First People′s Hospital of Longquanyi District Chengdu Chengdu Sichuan China
- 4Department of Gastroenterology Affiliated Hospital of Southwest Medical University Luzhou Sichuan China ahswmu.cn
Abstract
Helicobacter pylori (H. pylori), recognized as the primary pathogen responsible for chronic gastric infections, has exhibited an increasing prevalence of antibiotic resistance, which significantly impairs the efficacy of clinical treatments. In recent years, the extensive utilization of antibiotics alongside the rising prevalence of resistant strains has elevated the investigation of the resistance mechanisms of H. pylori to a prominent area of research. This article systematically examines the phenotypic characteristics associated with the antibiotic resistance of H. pylori, establishing a correspondence with resistance genotypes. Particular emphasis is placed on analyzing the resistance mechanisms linked to commonly prescribed antibiotics such as clarithromycin, metronidazole, and amoxicillin, in addition to the molecular characteristics of the relevant resistance genes (such as mutations in “gyrA,” “gyrB,” “23S rRNA,” “frxA,” “pbp1,” and “rdxA”). By merging advancements in molecular biology with findings from epidemiological studies, this review explores the potential application of resistance genotype detection in facilitating tailored clinical treatment approaches. The objective of this review is to enhance the understanding of the resistance mechanisms of H. pylori, fostering the development of precise diagnostic and therapeutic strategies and offering theoretical insights and future research pathways for the treatment of anti–H. pylori infections.
Related
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BibTeX
@article{gong2026advances,
title = {{Advances in Research on the Genotype–Phenotype Correspondence of Antibiotic Resistance in Helicobacter pylori and Its Molecular Mechanisms: A Narrative Review}},
author = {Hui Gong and Yan Chun Huang and Bo Yang and Zhen Yu Song and Xue Qiong Xu and Fang Cui Xiao and Rong Peng and Chang Ping Li},
journal = {Gastroenterology Research and Practice},
year = {2026},
month = oct,
doi = {10.1155/grp/4557969},
url = {https://doi.org/10.1155/grp/4557969},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Advances in Research on the Genotype–Phenotype Correspondence of Antibiotic Resistance in Helicobacter pylori and Its Molecular Mechanisms: A Narrative Review
AU - Hui Gong
AU - Yan Chun Huang
AU - Bo Yang
AU - Zhen Yu Song
AU - Xue Qiong Xu
AU - Fang Cui Xiao
AU - Rong Peng
AU - Chang Ping Li
PY - 2026
DA - 2026/10/26
JO - Gastroenterology Research and Practice
DO - 10.1155/grp/4557969
UR - https://doi.org/10.1155/grp/4557969
AB - Helicobacter pylori (H. pylori), recognized as the primary pathogen responsible for chronic gastric infections, has exhibited an increasing prevalence of antibiotic resistance, which significantly impairs the efficacy of clinical treatments. In recent years, the extensive utilization of antibiotics alongside the rising prevalence of resistant strains has elevated the investigation of the resistance mechanisms of H. pylori to a prominent area of research. This article systematically examines the phenotypic characteristics associated with the antibiotic resistance of H. pylori, establishing a correspondence with resistance genotypes. Particular emphasis is placed on analyzing the resistance mechanisms linked to commonly prescribed antibiotics such as clarithromycin, metronidazole, and amoxicillin, in addition to the molecular characteristics of the relevant resistance genes (such as mutations in “gyrA,” “gyrB,” “23S rRNA,” “frxA,” “pbp1,” and “rdxA”). By merging advancements in molecular biology with findings from epidemiological studies, this review explores the potential application of resistance genotype detection in facilitating tailored clinical treatment approaches. The objective of this review is to enhance the understanding of the resistance mechanisms of H. pylori, fostering the development of precise diagnostic and therapeutic strategies and offering theoretical insights and future research pathways for the treatment of anti–H. pylori infections.
SN - 1687-6121
SN - 1687-630X
ER -