Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 27 min ago
Peer-reviewedCC BY-NC 4.0Blood Purification

Evaluation of Splenic Volume and Oxygenation During Hemodialysis

  • Yusaku Watanabe1,2
  • Kiyonori Ito1
  • Hiroaki Nonaka1,2
  • Yuko Mutsuyoshi1
  • Junki Morino1
  • Haruhisa Miyazawa1
  • Jo Yoshizawa3
  • Sumiko Homma2
  • Mamoru Yoshizawa3
  • Yasushi Asano2
  • Yoshiyuki Morishita4
  • Susumu Ookawara1
4 affiliations
  1. 1Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan
  2. 2Division of Nephrology, Koga Red Cross Hospital, Koga, Ibaraki, Japan
  3. 3Division of Nephrology, Omiya Yoshizawa Clinic, Saitama, Japan
  4. 4Division of Nephrology, Department of Medicine, Jichi Medical University, Tochigi, Japan
Read full textPDFDOICite

Abstract

Introduction: During hemodialysis (HD), the redistribution of blood from the hepatosplanchnic vascular bed to the central circulation is a key compensatory response to ultrafiltration. A major blood reservoir, the spleen can expel red blood cells into the circulation upon contraction. However, changes in splenic volume and oxygenation during HD have yet to be fully investigated.

Methods: Splenic regional oxygen saturation (rSO2) was measured in 48 patients (33 men, 15 women) during HD using an INVOS 5100C oxygen saturation monitor (Covidien Japan, Tokyo, Japan). We assessed the spleen index by ultrasonography before and after the same HD session.

Results: The splenic rSO2 of patients undergoing HD was significantly lower than that of healthy controls (64.3 ± 13.4 vs. 87.0 ± 5.1%, p < 0.001). In contrast, no significant difference was detected between the pre- and post-HD values (64.3 ± 13.4 vs. 64.5 ± 13.6%, p = 0.890). The spleen index did not differ significantly between healthy control and pre-HD (31.3 [24–33] vs. 32.6 [23–40] cm2, p = 0.416). However, the spleen index decreased significantly after HD (32.6 [23–40] vs. 28.1 [20–35] cm2, p = 0.009). Multivariate regression analysis also showed that the pre-HD spleen index (standardized coefficient = −0.319), serum creatinine concentration (standardized coefficient = −0.492), and serum β2-microglobulin level (standardized coefficient = 0.344) were independently associated with changes in the spleen index.

Conclusion: In conclusion, splenic rSO2 did not change significantly during HD, whereas the spleen index decreased. This reduction may reflect active splenic contraction, passive venous decongestion, or both.

Related

  1. Determinants of MASLD and liver fibrosis in maintenance hemodialysis: a prospective evaluation of metabolic, nutritional, and volume-related factors.
    Leyla Koc, Caglayan Keklikkiran, Remzi Adnan Akdogan +1
    Diabetology & metabolic syndromePeer-reviewedCC BY-NC-NDFull textEpidemiology & public healthEurope PMCPMC
  2. Evaluation of Two Non-Invasive Extracorporeal Strategies for Enhancing Protein-Bound Uremic Toxin Removal During Hemodialysis.
    João G Brás, Fokko P Wieringa, Babette H Lentferink +8
    ToxinsPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  3. Splenic Volume Changes After Left Nephrectomy: A Retrospective Computed Tomography-Based Morphometric Study.
    Süniye Bilgiç Sal, Keziban Karacan, Alper Karacan +1
    Diagnostics (Basel, Switzerland)Peer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Ultrasound stimulation of hindlimb skeletal muscle is associated with selective differences in splenic metabolites during hindlimb unloading in mice
    Taketo Inoue, Nozomi Nishimura, Maximilian Dachs +9
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textPhysiologyCrossref
  5. Development of a volume management journey map for patients requiring hemodialysis
    Yuehong Wang, Yuan Xu, Ye Tian +5
    BMC NephrologyPeer-reviewedCC BYFull textGeneral medicineDOAJ

Cite

BibTeXRIS
BibTeX
@article{watanabe2026evaluation,
  title = {{Evaluation of Splenic Volume and Oxygenation During Hemodialysis}},
  author = {Yusaku Watanabe and Kiyonori Ito and Hiroaki Nonaka and Yuko Mutsuyoshi and Junki Morino and Haruhisa Miyazawa and Jo Yoshizawa and Sumiko Homma and Mamoru Yoshizawa and Yasushi Asano and Yoshiyuki Morishita and Susumu Ookawara},
  journal = {Blood Purification},
  year = {2026},
  month = oct,
  doi = {10.1159/bpu/abpag024},
  url = {https://doi.org/10.1159/bpu/abpag024},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Evaluation of Splenic Volume and Oxygenation During Hemodialysis
AU  - Yusaku Watanabe
AU  - Kiyonori Ito
AU  - Hiroaki Nonaka
AU  - Yuko Mutsuyoshi
AU  - Junki Morino
AU  - Haruhisa Miyazawa
AU  - Jo Yoshizawa
AU  - Sumiko Homma
AU  - Mamoru Yoshizawa
AU  - Yasushi Asano
AU  - Yoshiyuki Morishita
AU  - Susumu Ookawara
PY  - 2026
DA  - 2026/10/05
JO  - Blood Purification
DO  - 10.1159/bpu/abpag024
UR  - https://doi.org/10.1159/bpu/abpag024
AB  - Introduction: During hemodialysis (HD), the redistribution of blood from the hepatosplanchnic vascular bed to the central circulation is a key compensatory response to ultrafiltration. A major blood reservoir, the spleen can expel red blood cells into the circulation upon contraction. However, changes in splenic volume and oxygenation during HD have yet to be fully investigated.  Methods: Splenic regional oxygen saturation (rSO2) was measured in 48 patients (33 men, 15 women) during HD using an INVOS 5100C oxygen saturation monitor (Covidien Japan, Tokyo, Japan). We assessed the spleen index by ultrasonography before and after the same HD session.  Results: The splenic rSO2 of patients undergoing HD was significantly lower than that of healthy controls (64.3 ± 13.4 vs. 87.0 ± 5.1%, p < 0.001). In contrast, no significant difference was detected between the pre- and post-HD values (64.3 ± 13.4 vs. 64.5 ± 13.6%, p = 0.890). The spleen index did not differ significantly between healthy control and pre-HD (31.3 [24–33] vs. 32.6 [23–40] cm2, p = 0.416). However, the spleen index decreased significantly after HD (32.6 [23–40] vs. 28.1 [20–35] cm2, p = 0.009). Multivariate regression analysis also showed that the pre-HD spleen index (standardized coefficient = −0.319), serum creatinine concentration (standardized coefficient = −0.492), and serum β2-microglobulin level (standardized coefficient = 0.344) were independently associated with changes in the spleen index.  Conclusion: In conclusion, splenic rSO2 did not change significantly during HD, whereas the spleen index decreased. This reduction may reflect active splenic contraction, passive venous decongestion, or both.
SN  - 0253-5068
SN  - 1421-9735
ER  -