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Peer-reviewedCC BY 4.0ACS Omega

Rapid Aryne-Enabled Aryl Functionalization via Mechanically Assisted Microscale Mixing

  • Johanna Breinsperger1
  • Maximilian Kaiser1
  • Michael Schnürch1
  1. 1Institute of Applied Synthetic Chemistry, TU Wien , Getreidemarkt 9/163 , ,
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Abstract

Herein, we demonstrate that arynes can be generated and trapped efficiently through mechanically assisted microscale mixing on a standard vortex mixer. Brief vortex agitation enables ultra-fast generation and interception of these highly reactive intermediates with N-, O-, S-, and C-nucleophiles within 1 min, therefore providing a low-energy-solvent minimized approach for aryl functionalization without the need for inert atmosphere, heating, or bulk solvent.

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Cite

BibTeXRIS
BibTeX
@article{breinsperger2026rapid,
  title = {{Rapid Aryne-Enabled Aryl Functionalization via Mechanically Assisted Microscale Mixing}},
  author = {Johanna Breinsperger and Maximilian Kaiser and Michael Schnürch},
  journal = {ACS Omega},
  year = {2026},
  month = sep,
  doi = {10.1021/acsomega.6c09456},
  url = {https://pubs.acs.org/acsodf/article/11/40/62275/5442165/Rapid-Aryne-Enabled-Aryl-Functionalization-via},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Rapid Aryne-Enabled Aryl Functionalization via Mechanically Assisted Microscale Mixing
AU  - Johanna Breinsperger
AU  - Maximilian Kaiser
AU  - Michael Schnürch
PY  - 2026
DA  - 2026/09/30
JO  - ACS Omega
DO  - 10.1021/acsomega.6c09456
UR  - https://pubs.acs.org/acsodf/article/11/40/62275/5442165/Rapid-Aryne-Enabled-Aryl-Functionalization-via
AB  - Herein, we demonstrate that arynes can be generated and trapped efficiently through mechanically assisted microscale mixing on a standard vortex mixer. Brief vortex agitation enables ultra-fast generation and interception of these highly reactive intermediates with N-, O-, S-, and C-nucleophiles within 1 min, therefore providing a low-energy-solvent minimized approach for aryl functionalization without the need for inert atmosphere, heating, or bulk solvent.
SN  - 2470-1343
ER  -