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Peer-reviewedCC BY-NC-NDInternal Medicine

Tubulointerstitial Nephritis with IgM-positive Plasma Cells Requiring Temporary Hemodialysis

  • Hisashi Furukawa
  • Tsutomu Inoue
  • Haruko Oba
  • Tomohiro Ikezawa
  • Tatsuo Kondo
  • Daichi Fukaya
  • Koji Tomori
  • Yusuke Watanabe
  • Mei Hamada
  • Keisuke Ishizawa
  • Naoki Takahashi
  • Hirokazu Okada
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Abstract

A 63-year-old Japanese woman was diagnosed with severe kidney dysfunction that required hemodialysis. Testing revealed an elevated serum IgM level (2,650 mg/dL). A kidney biopsy revealed tubulointerstitial nephritis with the infiltration of IgM and CD138 positive cells into the tubulointerstitium. The patient was diagnosed with tubulointerstitial nephritis with IgM-positive plasma cells (IgMPC-TIN) and required hemodialysis. Subsequently, the patient was treated with prednisolone, which improved her kidney function and led to the discontinuation of hemodialysis. Patients with IgMPC-TIN may experience a marked decline in kidney function; however, corticosteroid treatment can improve the outcomes in patients with severe kidney dysfunction.

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Cite

BibTeXRIS
BibTeX
@article{furukawa2026tubulointerstitial,
  title = {{Tubulointerstitial Nephritis with IgM-positive Plasma Cells Requiring Temporary Hemodialysis}},
  author = {Hisashi Furukawa and Tsutomu Inoue and Haruko Oba and Tomohiro Ikezawa and Tatsuo Kondo and Daichi Fukaya and Koji Tomori and Yusuke Watanabe and Mei Hamada and Keisuke Ishizawa and Naoki Takahashi and Hirokazu Okada},
  journal = {Internal Medicine},
  year = {2026},
  month = oct,
  doi = {10.2169/internalmedicine.6795-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/19/65_6795-25/_article},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Tubulointerstitial Nephritis with IgM-positive Plasma Cells Requiring Temporary Hemodialysis
AU  - Hisashi Furukawa
AU  - Tsutomu Inoue
AU  - Haruko Oba
AU  - Tomohiro Ikezawa
AU  - Tatsuo Kondo
AU  - Daichi Fukaya
AU  - Koji Tomori
AU  - Yusuke Watanabe
AU  - Mei Hamada
AU  - Keisuke Ishizawa
AU  - Naoki Takahashi
AU  - Hirokazu Okada
PY  - 2026
DA  - 2026/10/01
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6795-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/19/65_6795-25/_article
AB  - A 63-year-old Japanese woman was diagnosed with severe kidney dysfunction that required hemodialysis. Testing revealed an elevated serum IgM level (2,650 mg/dL). A kidney biopsy revealed tubulointerstitial nephritis with the infiltration of IgM and CD138 positive cells into the tubulointerstitium. The patient was diagnosed with tubulointerstitial nephritis with IgM-positive plasma cells (IgMPC-TIN) and required hemodialysis. Subsequently, the patient was treated with prednisolone, which improved her kidney function and led to the discontinuation of hemodialysis. Patients with IgMPC-TIN may experience a marked decline in kidney function; however, corticosteroid treatment can improve the outcomes in patients with severe kidney dysfunction.
SN  - 1349-7235
SN  - 0918-2918
ER  -