The role of PANSS-G12-rated clinical insight in self-reporting the impact of symptoms in patients with schizophrenia living in the community
11 affiliations
- 1Mental Health and Addictions Network, Institut d'Assistència Sanitària (IAS), Parc Hospitalari Martí i Julià, Edifici Til·lers, Salt, 17190, Spain.
- 2Mental Health and Addictions Research Group, Institut d'Investigació Biomèdica de Girona (IDIBGI-CERCA), Parc Hospitalari Martí i Julià, Edifici M2, Salt, 17190, Spain.
- 3Department of Statistics and Operational Research, Faculty of Medicine, University of Cadiz, Plaza Falla, 9, Cadiz, Spain.
- 4Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Monforte de Lemos 3-5, Pabellón 11, planta 0, Madrid, 28029, Spain.
- 5Department of Psychology, University of Cadiz, Republica Saharaui, s/n, Puerto Real, 11519, Spain.
- 6Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, University of Cádiz, Cádiz, Spain.
- 7Etiopathogenesis and treatment of severe mental disorders Group (MERITT), Institut de Recerca Sant Joan de Déu, Parc Sanitari Sant Joan de Déu, Dr. Pujades, 42, 08330 Sant Boi de Llobregat, Barcelona, Spain.
- 8Health Research Institute, University of Canberra, 11 Kirinari Street, Bruce, ACT, 2617, Australia.
- 9Department of Personality, Assessment and Psychological Treatment, University of Malaga, C/. Doctor Ortiz Ramos, 12, Ampliación de Teatinos, 29010, Málaga, 29071, Spain.
- 10Andalusian Group of Psychosocial Research (CTS-945), Department of Personality, Assessment and Psychological Treatment, University of Malaga, C/. Doctor Ortiz Ramos, 12, Ampliación deTeatinos, Málaga, 29071, Spain.
- 11Biomedical Research Institute of Malaga (IBIMA), Calle Severo Ochoa, 35, Málaga, 29590, Spain.
Abstract
Background
Impaired insight is common in schizophrenia and may influence the interpretation of patient-reported outcome measures, which are increasingly used in patient-centred care and research. However, little is known about how insight relates to self-reported symptom impact. This study examined this relationship in people with schizophrenia in community settings.Methods
Latent class analysis was applied to responses from 162 participants on the Patient-Reported Impact of Symptoms in Schizophrenia (PRISS) scale. Sociodemographic, clinical and functional disability variables were analysed as predictors of class membership. Insight was assessed using the Positive and Negative Syndrome Scale (PANSS) G12 item in a subset of participants. Invariance analyses evaluated the consistency of the latent class structure across samples and gender.Results
A four-class model was identified: Low symptom impact (50.62%); Disorganisation (26.54%); Suspiciousness (10.5%); and Severe (12.35%). The Severe clas showed a higher prevalence of clinician-rated negative symptoms. No association was observed between PANSS-G12-rated clinical insight and self-reported negative symptoms. The latent class structure was invariant across samples and gender, although women more frequently reported disturbance of volition, depression and feelings of guilt. Disability, psychological treatment and hospitalisation history were associated with class membership.Conclusions
Findings suggest that impaired PANSS-G12-rated clinical insight is associated with greater self-reported impact of disorganisation and suspiciousness, but not with the self-reported impact of negative symptoms. Four distinct profiles of symptom impact were identified, with self-reported depression being more prevalent in the most severe profile. These findings may support patient-centred assessment in schizophrenia.
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BibTeX
@article{frigolacapell2026role,
title = {{The role of PANSS-G12-rated clinical insight in self-reporting the impact of symptoms in patients with schizophrenia living in the community}},
author = {Eva Frigola-Capell and Juan Luis González-Caballero and Jordi Cid and Cristina Romero-López-Alberca and Susana Ochoa and Regina Vila-Badia and Luis Salvador-Carulla and Berta Moreno-Küstnerh},
journal = {Schizophrenia research. Cognition},
year = {2026},
month = oct,
doi = {10.1016/j.scog.2026.100465},
url = {https://europepmc.org/article/PMC/PMC13716961},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - The role of PANSS-G12-rated clinical insight in self-reporting the impact of symptoms in patients with schizophrenia living in the community
AU - Eva Frigola-Capell
AU - Juan Luis González-Caballero
AU - Jordi Cid
AU - Cristina Romero-López-Alberca
AU - Susana Ochoa
AU - Regina Vila-Badia
AU - Luis Salvador-Carulla
AU - Berta Moreno-Küstnerh
PY - 2026
DA - 2026/10/20
JO - Schizophrenia research. Cognition
DO - 10.1016/j.scog.2026.100465
UR - https://europepmc.org/article/PMC/PMC13716961
AB - Background Impaired insight is common in schizophrenia and may influence the interpretation of patient-reported outcome measures, which are increasingly used in patient-centred care and research. However, little is known about how insight relates to self-reported symptom impact. This study examined this relationship in people with schizophrenia in community settings.Methods Latent class analysis was applied to responses from 162 participants on the Patient-Reported Impact of Symptoms in Schizophrenia (PRISS) scale. Sociodemographic, clinical and functional disability variables were analysed as predictors of class membership. Insight was assessed using the Positive and Negative Syndrome Scale (PANSS) G12 item in a subset of participants. Invariance analyses evaluated the consistency of the latent class structure across samples and gender.Results A four-class model was identified: Low symptom impact (50.62%); Disorganisation (26.54%); Suspiciousness (10.5%); and Severe (12.35%). The Severe clas showed a higher prevalence of clinician-rated negative symptoms. No association was observed between PANSS-G12-rated clinical insight and self-reported negative symptoms. The latent class structure was invariant across samples and gender, although women more frequently reported disturbance of volition, depression and feelings of guilt. Disability, psychological treatment and hospitalisation history were associated with class membership.Conclusions Findings suggest that impaired PANSS-G12-rated clinical insight is associated with greater self-reported impact of disorganisation and suspiciousness, but not with the self-reported impact of negative symptoms. Four distinct profiles of symptom impact were identified, with self-reported depression being more prevalent in the most severe profile. These findings may support patient-centred assessment in schizophrenia.
SN - 2215-0013
ER -