HEMATOLOGICAL PROFILE OF WOMEN WITH RECURRENT PREGNANCY LOSS: A CROSS-SECTIONAL STUDY AT SPECIALIZED CARE CENTERS IN SALVADOR, BAHIA, BRAZIL
5 affiliations
- 1Faculdade de Farmácia da Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil
- 2Instituto Gonçalo Moniz (IGM), FIOCRUZ, Salvador, BA, Brazil
- 3Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil
- 4Maternidade Climério de Oliveira (COM), Salvador, BA, Brazil
- 5Faculdade de Medicina da Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil
Abstract
Introduction: Recurrent Pregnancy Loss (RPL) is a reproductive condition with a multifactorial etiology that may be associated with hematological, immunological, thrombo-inflammatory, and hemostatic alterations. The evaluation of hematological parameters may contribute to a better understanding of the mechanisms involved in the pathophysiology of RPL (ASRM, 2026). Objective: To characterize the hematological profile and levels of natural anticoagulant proteins in women diagnosed with RPL. Methods: A cross-sectional study was conducted among 287 women with RPL receiving care at specialized services in Salvador, Bahia, Brazil. Laboratory data, including complete blood counts and natural anticoagulant proteins, were collected. Continuous variables were presented as mean ± standard deviation or median and interquartile range (IQR), according to the results of normality testing. Ethics Approval: CAAE 83666724.3.0000.8035. Results: Hematological parameters were within the reference ranges, with hemoglobin at 13.1 g/dL (IQR: 12.5–13.8), hematocrit at 38.3% (IQR: 36.2–40.2), total leukocyte count at 7.39 ×10 3 /µL (IQR: 5.63–9.13), and platelet count at 288 ×10 3 /µL (IQR: 237–330). Natural anticoagulant levels were preserved, with protein C (PC) at 104.8±20.8%, protein S (PS) at 87.3±19.0%, and antithrombin (AT) at 106.3±11.7%. Discussion: The apparent preservation of standard hematological parameters does not exclude more subtle alterations related to the inflammatory response and hematopoiesis. In a recent study of 531 women with RPL, those who experienced a subsequent pregnancy loss had higher erythrocyte, leukocyte, and lymphocyte counts, as well as alterations in RDW and MCV. Some of these parameters remained associated with the outcome after multivariate adjustment (MU et al., 2025). Together with the findings of the present study, these results suggest that blood count assessment in RPL may be more informative when considering not only absolute blood cell counts but also the patient’s inflammatory and metabolic context. Levels of PC, PS, and AT remained within the reference ranges. Similar findings were reported by Mekaj et al. (2015) in women with RPL, among whom no significant differences were observed in the mean levels of these anticoagulant proteins compared with controls. However, the combined occurrence of alterations in AT, PC, PS, and/or activated protein C resistance was more frequent among patients with RPL than among controls (21.15% vs. 5.45%). These findings suggest that an analysis based on mean values may not identify hemostatic alterations present in subgroups of women with RPL, highlighting the importance of individually assessing the components of the natural anticoagulant system. Conclusion: Women with RPL had hematological parameters within the reference ranges. The combined assessment of inflammatory and hemostatic markers may contribute to a better understanding of RPL.
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BibTeX
@article{neto2026hematological,
title = {{HEMATOLOGICAL PROFILE OF WOMEN WITH RECURRENT PREGNANCY LOSS: A CROSS-SECTIONAL STUDY AT SPECIALIZED CARE CENTERS IN SALVADOR, BAHIA, BRAZIL}},
author = {Francisco Das Chagas Barros NETO and Victoria Nascimento SUZART and Elisangela Vitoria ADORNO and Isabella Lima RIBEIRO and Gabriela Moraes SANTANA and Taíse Lalesca de Oliveira SILVA and Robson Da Paixão de SOUZA and Márcia Cristina Santana MOREIRA and Manoel Alfredo Curvelo SARNO and Carlos Augusto Santos de MENEZES and Sabrina Oliveira de CARVALHO and Cynara Gomes BARBOSA},
journal = {Hematology, Transfusion and Cell Therapy},
year = {2026},
month = oct,
doi = {10.1016/j.htct.2026.106735},
url = {https://doi.org/10.1016/j.htct.2026.106735},
note = {CC BY},
}
RIS
TY - JOUR
TI - HEMATOLOGICAL PROFILE OF WOMEN WITH RECURRENT PREGNANCY LOSS: A CROSS-SECTIONAL STUDY AT SPECIALIZED CARE CENTERS IN SALVADOR, BAHIA, BRAZIL
AU - Francisco Das Chagas Barros NETO
AU - Victoria Nascimento SUZART
AU - Elisangela Vitoria ADORNO
AU - Isabella Lima RIBEIRO
AU - Gabriela Moraes SANTANA
AU - Taíse Lalesca de Oliveira SILVA
AU - Robson Da Paixão de SOUZA
AU - Márcia Cristina Santana MOREIRA
AU - Manoel Alfredo Curvelo SARNO
AU - Carlos Augusto Santos de MENEZES
AU - Sabrina Oliveira de CARVALHO
AU - Cynara Gomes BARBOSA
PY - 2026
DA - 2026/10/23
JO - Hematology, Transfusion and Cell Therapy
DO - 10.1016/j.htct.2026.106735
UR - https://doi.org/10.1016/j.htct.2026.106735
AB - Introduction: Recurrent Pregnancy Loss (RPL) is a reproductive condition with a multifactorial etiology that may be associated with hematological, immunological, thrombo-inflammatory, and hemostatic alterations. The evaluation of hematological parameters may contribute to a better understanding of the mechanisms involved in the pathophysiology of RPL (ASRM, 2026). Objective: To characterize the hematological profile and levels of natural anticoagulant proteins in women diagnosed with RPL. Methods: A cross-sectional study was conducted among 287 women with RPL receiving care at specialized services in Salvador, Bahia, Brazil. Laboratory data, including complete blood counts and natural anticoagulant proteins, were collected. Continuous variables were presented as mean ± standard deviation or median and interquartile range (IQR), according to the results of normality testing. Ethics Approval: CAAE 83666724.3.0000.8035. Results: Hematological parameters were within the reference ranges, with hemoglobin at 13.1 g/dL (IQR: 12.5–13.8), hematocrit at 38.3% (IQR: 36.2–40.2), total leukocyte count at 7.39 ×10 3 /µL (IQR: 5.63–9.13), and platelet count at 288 ×10 3 /µL (IQR: 237–330). Natural anticoagulant levels were preserved, with protein C (PC) at 104.8±20.8%, protein S (PS) at 87.3±19.0%, and antithrombin (AT) at 106.3±11.7%. Discussion: The apparent preservation of standard hematological parameters does not exclude more subtle alterations related to the inflammatory response and hematopoiesis. In a recent study of 531 women with RPL, those who experienced a subsequent pregnancy loss had higher erythrocyte, leukocyte, and lymphocyte counts, as well as alterations in RDW and MCV. Some of these parameters remained associated with the outcome after multivariate adjustment (MU et al., 2025). Together with the findings of the present study, these results suggest that blood count assessment in RPL may be more informative when considering not only absolute blood cell counts but also the patient’s inflammatory and metabolic context. Levels of PC, PS, and AT remained within the reference ranges. Similar findings were reported by Mekaj et al. (2015) in women with RPL, among whom no significant differences were observed in the mean levels of these anticoagulant proteins compared with controls. However, the combined occurrence of alterations in AT, PC, PS, and/or activated protein C resistance was more frequent among patients with RPL than among controls (21.15% vs. 5.45%). These findings suggest that an analysis based on mean values may not identify hemostatic alterations present in subgroups of women with RPL, highlighting the importance of individually assessing the components of the natural anticoagulant system. Conclusion: Women with RPL had hematological parameters within the reference ranges. The combined assessment of inflammatory and hemostatic markers may contribute to a better understanding of RPL.
SN - 2531-1379
SN - 2531-1387
ER -