Predictive Accuracy of the Advanced-DiaRem Score for Type 2 Diabetes Remission After Sleeve Gastrectomy in a Persian Cohort.
4 affiliations
- 1Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
- 2Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.
- 3Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
- 4Artificial Intelligence in Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
Abstract
Aims
This study evaluated the performance of the Advanced-DiaRem scoring system for predicting initial remission of type II diabetes mellitus (T2DM) after sleeve gastrectomy (SG) in the Persian population.Methods
A retrospective cohort study with cross-sectional telephone interviews was conducted, including adults with T2DM who underwent SG between 2016 and 2023. Baseline clinical, biochemical, and diabetes-related variables were collected, and Advanced-DiaRem scores were calculated. The primary outcome was initial T2DM remission, defined as initial physiological success rather than long-term, sustained remission. Receiver Operating Characteristic (ROC) curve analysis using Youden's Index evaluated model discrimination, and Decision Curve Analysis quantified clinical utility. Multivariable logistic regression identified independent predictors of initial remission.Results
Ninety-three patients (72.0% female) with a mean age of 49.1 ± 9.8 years were included, of whom 45.2% (95% CI: 34.9, 55.5) achieved initial remission. Remission was significantly associated with baseline HbA1c levels. The Advanced-DiaRem scoring system showed limited discriminatory performance (AUC 64.5%); the optimal cutoff <9 yielded 69% sensitivity, 59% specificity, 58% PPV, 70% NPV, 63% accuracy, LR+ of 1.68, and LR- of 0.53.Conclusion
The Advanced-DiaRem score showed limited accuracy in predicting initial T2DM remission after SG in this cohort. This study suggests that model recalibration or the development of population-specific prediction tools may improve predictive accuracy.
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BibTeX
@article{karimi2026predictive,
title = {{Predictive Accuracy of the Advanced-DiaRem Score for Type 2 Diabetes Remission After Sleeve Gastrectomy in a Persian Cohort.}},
author = {Yeganeh Karimi and Arash Abdollahi and Maziar Afshar and Ali Kabir},
journal = {Diabetes, metabolic syndrome and obesity : targets and therapy},
year = {2026},
month = oct,
doi = {10.2147/dmso.s589859},
url = {https://europepmc.org/article/MED/42968850},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Predictive Accuracy of the Advanced-DiaRem Score for Type 2 Diabetes Remission After Sleeve Gastrectomy in a Persian Cohort.
AU - Yeganeh Karimi
AU - Arash Abdollahi
AU - Maziar Afshar
AU - Ali Kabir
PY - 2026
DA - 2026/10/28
JO - Diabetes, metabolic syndrome and obesity : targets and therapy
DO - 10.2147/dmso.s589859
UR - https://europepmc.org/article/MED/42968850
AB - Aims This study evaluated the performance of the Advanced-DiaRem scoring system for predicting initial remission of type II diabetes mellitus (T2DM) after sleeve gastrectomy (SG) in the Persian population.Methods A retrospective cohort study with cross-sectional telephone interviews was conducted, including adults with T2DM who underwent SG between 2016 and 2023. Baseline clinical, biochemical, and diabetes-related variables were collected, and Advanced-DiaRem scores were calculated. The primary outcome was initial T2DM remission, defined as initial physiological success rather than long-term, sustained remission. Receiver Operating Characteristic (ROC) curve analysis using Youden's Index evaluated model discrimination, and Decision Curve Analysis quantified clinical utility. Multivariable logistic regression identified independent predictors of initial remission.Results Ninety-three patients (72.0% female) with a mean age of 49.1 ± 9.8 years were included, of whom 45.2% (95% CI: 34.9, 55.5) achieved initial remission. Remission was significantly associated with baseline HbA1c levels. The Advanced-DiaRem scoring system showed limited discriminatory performance (AUC 64.5%); the optimal cutoff <9 yielded 69% sensitivity, 59% specificity, 58% PPV, 70% NPV, 63% accuracy, LR+ of 1.68, and LR- of 0.53.Conclusion The Advanced-DiaRem score showed limited accuracy in predicting initial T2DM remission after SG in this cohort. This study suggests that model recalibration or the development of population-specific prediction tools may improve predictive accuracy.
SN - 1178-7007
ER -