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Peer-reviewedCC BYCureus

When Mammary-Like Anogenital Glands Go Rogue: Vulvar Phyllodes Tumor With Incorporated Hidradenoma Papilliferum.

  • Mariam N Albrahim1
  • Rajan Arora1
  • Ramani Samudrala2
  1. 1Pathology and Laboratory Medicine, Farwaniya Hospital, Farwaniya, KWT.
  2. 2Obstetrics and Gynecology, Farwaniya Hospital, Farwaniya, KWT.
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Abstract

Vulvar phyllodes tumor is a rare fibroepithelial neoplasm with morphologic features resembling mammary phyllodes tumor. Hidradenoma papilliferum is a benign anogenital neoplasm associated with mammary-like anogenital glands. We report a 55-year-old female patient with a three-year history of an asymptomatic right labial mass clinically diagnosed as a sebaceous cyst. Histopathologic examination revealed a benign phyllodes tumor with an incorporated glandular proliferation consistent with hidradenoma papilliferum. Immunohistochemistry demonstrated a p63-positive myoepithelial layer. To the best of our knowledge, this association has not been previously reported. This case expands the recognized morphologic spectrum of mammary-like gland-associated vulvar neoplasia and highlights the importance of recognizing both patterns within a single lesion.

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Cite

BibTeXRIS
BibTeX
@article{albrahim2026when,
  title = {{When Mammary-Like Anogenital Glands Go Rogue: Vulvar Phyllodes Tumor With Incorporated Hidradenoma Papilliferum.}},
  author = {Mariam N Albrahim and Rajan Arora and Ramani Samudrala},
  journal = {Cureus},
  year = {2026},
  month = sep,
  doi = {10.7759/cureus.116700},
  url = {https://europepmc.org/article/MED/42923274},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - When Mammary-Like Anogenital Glands Go Rogue: Vulvar Phyllodes Tumor With Incorporated Hidradenoma Papilliferum.
AU  - Mariam N Albrahim
AU  - Rajan Arora
AU  - Ramani Samudrala
PY  - 2026
DA  - 2026/09/22
JO  - Cureus
DO  - 10.7759/cureus.116700
UR  - https://europepmc.org/article/MED/42923274
AB  - Vulvar phyllodes tumor is a rare fibroepithelial neoplasm with morphologic features resembling mammary phyllodes tumor. Hidradenoma papilliferum is a benign anogenital neoplasm associated with mammary-like anogenital glands. We report a 55-year-old female patient with a three-year history of an asymptomatic right labial mass clinically diagnosed as a sebaceous cyst. Histopathologic examination revealed a benign phyllodes tumor with an incorporated glandular proliferation consistent with hidradenoma papilliferum. Immunohistochemistry demonstrated a p63-positive myoepithelial layer. To the best of our knowledge, this association has not been previously reported. This case expands the recognized morphologic spectrum of mammary-like gland-associated vulvar neoplasia and highlights the importance of recognizing both patterns within a single lesion.
SN  - 2168-8184
ER  -