Risk factors for postoperative nausea and vomiting after sleeve gastrectomy and the impact of intraoperative ondansetron: a retrospective cohort study
- 1Department of Anesthesiology and Intensive Care, Municipal Hospital, Olsztyn, Poland
- 2Department of General and Oncological Surgery, Specialist Hospital, Lublin, Poland
- 3Department of General, Minimally-Invasive, and Elderly Surgery, University of Warmia and Mazury, Olsztyn, Poland
Abstract
INTRODUCTION:: Postoperative nausea and vomiting (PONV) remain common adverse postoperative events after sleeve gastrectomy (SG), and they may negatively affect patient recovery.
AIM:: The aim of this study was to identify risk factors for PONV after SG and to evaluate the impact of intraoperative ondansetron administration on both the occurrence and severity of PONV.
MATERIALS AND METHODS:: A retrospective analysis of patients who underwent primary SG between 2024 and 2025 in a single bariatric center was conducted. Since PONV episodes were not recorded directly, the symptoms were assessed indirectly based on antiemetic consumption. Any PONV was defined as administration of at least 8 mg of ondansetron within 24 hours after surgery, whereas severe PONV was defined as a requirement for 16 mg of ondansetron or more with or without additional antiemetic agents.
RESULTS:: A total of 463 patients were included. Any PONV occurred in 195 patients (42.1%), while severe PONV was observed in 57 individuals (12.3%). Male sex (odds ratio [OR], 0.36; 95% CI, 0.22–0.61; P <0.001), older age (OR, 0.97; 95% CI, 0.95–0.99; P = 0.01), elevated body mass index (OR, 0.96; 95% CI, 0.93–1; P = 0.03), hypertension (OR, 0.53; 95% CI, 0.33–0.83; P = 0.006), and intraoperative ondansetron administration (OR, 0.38; 95% CI, 0.24–0.58; P <0.001) were independently associated with a lower risk of any PONV. Male sex was an independent protective factor against severe PONV (OR, 0.11; 95% CI, 0.03–0.48; P = 0.003).
CONCLUSIONS:: Intraoperative ondansetron administration was associated with a lower risk of PONV after SG. Male sex was the only independent protective factor against severe PONV, while ondansetron showed no significant effect on the occurrence of severe symptoms.
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BibTeX
@article{dobruchowskakesikowska2026risk,
title = {{Risk factors for postoperative nausea and vomiting after sleeve gastrectomy and the impact of intraoperative ondansetron: a retrospective cohort study}},
author = {Eliza Dobruchowska-Kęsikowska and Mateusz Wityk and Dominika Mysiorska and Julia Młyńska and Natalia Mazek and Natalia Dowgiałło-Gornowicz},
journal = {Videosurgery and other Miniinvasive Techniques},
year = {2026},
month = aug,
doi = {10.20452/wiitm.2026.18043},
url = {https://doi.org/10.20452/wiitm.2026.18043},
note = {CC BY-NC-SA 4.0},
}
RIS
TY - JOUR
TI - Risk factors for postoperative nausea and vomiting after sleeve gastrectomy and the impact of intraoperative ondansetron: a retrospective cohort study
AU - Eliza Dobruchowska-Kęsikowska
AU - Mateusz Wityk
AU - Dominika Mysiorska
AU - Julia Młyńska
AU - Natalia Mazek
AU - Natalia Dowgiałło-Gornowicz
PY - 2026
DA - 2026/08/27
JO - Videosurgery and other Miniinvasive Techniques
DO - 10.20452/wiitm.2026.18043
UR - https://doi.org/10.20452/wiitm.2026.18043
AB - INTRODUCTION:: Postoperative nausea and vomiting (PONV) remain common adverse postoperative events after sleeve gastrectomy (SG), and they may negatively affect patient recovery. AIM:: The aim of this study was to identify risk factors for PONV after SG and to evaluate the impact of intraoperative ondansetron administration on both the occurrence and severity of PONV. MATERIALS AND METHODS:: A retrospective analysis of patients who underwent primary SG between 2024 and 2025 in a single bariatric center was conducted. Since PONV episodes were not recorded directly, the symptoms were assessed indirectly based on antiemetic consumption. Any PONV was defined as administration of at least 8 mg of ondansetron within 24 hours after surgery, whereas severe PONV was defined as a requirement for 16 mg of ondansetron or more with or without additional antiemetic agents. RESULTS:: A total of 463 patients were included. Any PONV occurred in 195 patients (42.1%), while severe PONV was observed in 57 individuals (12.3%). Male sex (odds ratio [OR], 0.36; 95% CI, 0.22–0.61; P <0.001), older age (OR, 0.97; 95% CI, 0.95–0.99; P = 0.01), elevated body mass index (OR, 0.96; 95% CI, 0.93–1; P = 0.03), hypertension (OR, 0.53; 95% CI, 0.33–0.83; P = 0.006), and intraoperative ondansetron administration (OR, 0.38; 95% CI, 0.24–0.58; P <0.001) were independently associated with a lower risk of any PONV. Male sex was an independent protective factor against severe PONV (OR, 0.11; 95% CI, 0.03–0.48; P = 0.003). CONCLUSIONS:: Intraoperative ondansetron administration was associated with a lower risk of PONV after SG. Male sex was the only independent protective factor against severe PONV, while ondansetron showed no significant effect on the occurrence of severe symptoms.
SN - 1895-4588
SN - 2299-0054
ER -