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Peer-reviewedCC BYFrontiers in immunology

Evaluating the in vivo effects of Aspirin on vaginal inflammation and barrier function.

  • Morgan K Taverner1
  • Marina Costa Fujishima2
  • Deesha Nayar2
  • Camila Oda2
  • Calvin Wong3
  • Lyle R McKinnon1,4,5
  • Emmanuel A Ho3
  • Keith R Fowke1,5,6
  • Thomas T Murooka1,2
6 affiliations
  1. 1Department of Medical Microbiology and Infectious Diseases, Faculty of Health SciencesUniversity of Manitoba, Winnipeg, MB, Canada.
  2. 2Department of Immunology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
  3. 3School of Pharmacy, Faculty of Science, University of Waterloo, Kitchener, ON, Canada.
  4. 4Centre for the AIDS Programme of Research in South African (CAPRISA), Durban, South Africa.
  5. 5Department of Medical Microbiology and Immunology, University of Nairobi, Nairobi, Kenya.
  6. 6Partners for Health and Development in African, Nairobi, Kenya.
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Abstract

Inflammation is an important component of protective immunity in the lower female genital tract but must be tightly regulated to limit host tissue damage. In this study, we evaluated the in vivo potential of the anti-inflammatory drug Acetylsalicylic Acid (ASA) to lower proinflammatory cytokine production, restore vaginal barrier integrity and reduce the frequency of activated T cells that serve as targets for HIV infection. Daily intraperitoneal administration of ASA in mice had no effect on epithelial layer structure and CD4⁺ T cell activation status at homeostasis but significantly reduced barrier disruption in response to inflammatory bacteria Mobiluncus mulieris (M. muleiris). ASA treatment lowered the frequency of activated CXCR6⁺ TH17 subsets in the vaginal mucosa in response to M. muleiris and Gardnerella vaginalis challenge, also reducing the number of CCR5⁺ T cells in the latter. RNAseq analysis of the draining lymph nodes indicate that ASA treatment modulates immunologic and metabolic pathways associated with inflammation, cytokine signaling and cell-cell junction proteins. Our data indicate that ASA administration may reduce inflammation and help restore vaginal homeostasis in mice and aligns with human cohort studies evaluating the potential for oral ASA to reduce HIV transmission.

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Cite

BibTeXRIS
BibTeX
@article{taverner2026evaluating,
  title = {{Evaluating the in vivo effects of Aspirin on vaginal inflammation and barrier function.}},
  author = {Morgan K Taverner and Marina Costa Fujishima and Deesha Nayar and Camila Oda and Calvin Wong and Lyle R McKinnon and Emmanuel A Ho and Keith R Fowke and Thomas T Murooka},
  journal = {Frontiers in immunology},
  year = {2026},
  month = sep,
  doi = {10.3389/fimmu.2026.1901550},
  url = {https://europepmc.org/article/MED/42835080},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Evaluating the in vivo effects of Aspirin on vaginal inflammation and barrier function.
AU  - Morgan K Taverner
AU  - Marina Costa Fujishima
AU  - Deesha Nayar
AU  - Camila Oda
AU  - Calvin Wong
AU  - Lyle R McKinnon
AU  - Emmanuel A Ho
AU  - Keith R Fowke
AU  - Thomas T Murooka
PY  - 2026
DA  - 2026/09/21
JO  - Frontiers in immunology
DO  - 10.3389/fimmu.2026.1901550
UR  - https://europepmc.org/article/MED/42835080
AB  - Inflammation is an important component of protective immunity in the lower female genital tract but must be tightly regulated to limit host tissue damage. In this study, we evaluated the in vivo potential of the anti-inflammatory drug Acetylsalicylic Acid (ASA) to lower proinflammatory cytokine production, restore vaginal barrier integrity and reduce the frequency of activated T cells that serve as targets for HIV infection. Daily intraperitoneal administration of ASA in mice had no effect on epithelial layer structure and CD4⁺ T cell activation status at homeostasis but significantly reduced barrier disruption in response to inflammatory bacteria Mobiluncus mulieris (M. muleiris). ASA treatment lowered the frequency of activated CXCR6⁺ TH17 subsets in the vaginal mucosa in response to M. muleiris and Gardnerella vaginalis challenge, also reducing the number of CCR5⁺ T cells in the latter. RNAseq analysis of the draining lymph nodes indicate that ASA treatment modulates immunologic and metabolic pathways associated with inflammation, cytokine signaling and cell-cell junction proteins. Our data indicate that ASA administration may reduce inflammation and help restore vaginal homeostasis in mice and aligns with human cohort studies evaluating the potential for oral ASA to reduce HIV transmission.
SN  - 1664-3224
ER  -