Skip to content
DraconiticResearch
Search Sources API
184,937 studies31 sourcesUpdated 42 min ago
Peer-reviewedCC BY 4.0Frontiers in Immunology

Case Report: Interleukin-17A blockade for SAPHO syndrome presenting as an FDG-avid destructive osteolytic acetabular lesion

  • Shu Liu1
  • Anning Wang1
  • Yiming Yuan1
  • Xiaomin Yan2
  • Xianfeng Yang3
  • Qiong Jiao4
  • Zhiyong Chen5
  • Shiying Wang1
5 affiliations
  1. 1Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
  2. 2Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
  3. 3Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
  4. 4Department of Pathology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
  5. 5Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Read full textPDFDOICite

Abstract

SAPHO syndrome is an autoinflammatory osteitis disorder that may be misdiagnosed when bone destruction dominates the presentation. We report a 27-year-old woman with 7 months of left hip pain and intermittent anterior chest-wall pain. Imaging revealed an FDG-avid destructive osteolytic lesion in the left acetabulum and adjacent ilium, initially raising concern for malignancy, lymphoma, Langerhans-cell histiocytosis, or infection. Repeated tissue sampling showed chronic sterile osteomyelitis-like inflammation without evidence of malignancy or a reproducible pathogen. The disease evolved with pustular eruption after tumor necrosis factor inhibition, insufficient axial imaging control with Janus kinase inhibition, and marked improvement of a T12 vertebral-corner inflammatory lesion after interleukin-17A blockade with secukinumab. This case highlights the value of longitudinal clinicopathologic reassessment in destructive inflammatory bone disease and suggests that IL-17A blockade may be a rational strategy for SAPHO syndrome with active axial osteitis and pustular inflammation.

Related

  1. Targeting O-GlcNAcylation in tumor-associated macrophages: from metabolic reprogramming to osteolytic niche formation in bone-invasive solid tumors
    Shengqian Li, Yuan Zhi, Shaoming Li +6
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0ImmunologyCrossref
  2. The enlightened entomologist: fast, non-destructive whole-arthropod clearing for three-dimensional imaging
    M. Moulzir, H. Touja, M. Oheim +1
    bioRxivPreprintAll rights reservedFull textZoology & animal behaviourbioRxiv
  3. Recent advancements on innovative technologies and applications for non-destructive monitoring of tomato quality
    Yirui Huang, Jiahao Gu, Mingyu Yang +4
    Frontiers in plant sciencePeer-reviewedCC BYFull textPlant biologyEurope PMC
  4. RGB-Based Non-Destructive Measurement of Greenhouse Tomato Fruit Traits Using High-Fidelity Segmentation
    Ke Zhang, Aoxue Shen, Ruocheng Gao +7
    Plants (Basel, Switzerland)Peer-reviewedCC BYFull textPlant biologyEurope PMC
  5. Near-infrared spectroscopy for rapid and non-destructive assessment of PFAS effects in blue mussels (Mytilus spp.): a proof-of-concept study
    Colleen Guinle, Cécile Levasseur-Garcia, Laurence Poirier +2
    Marine Pollution BulletinPeer-reviewedCC BY 4.0Full textGeneral biochemistryGeneral biologyHAL

Cite

BibTeXRIS
BibTeX
@article{liu2026case,
  title = {{Case Report: Interleukin-17A blockade for SAPHO syndrome presenting as an FDG-avid destructive osteolytic acetabular lesion}},
  author = {Shu Liu and Anning Wang and Yiming Yuan and Xiaomin Yan and Xianfeng Yang and Qiong Jiao and Zhiyong Chen and Shiying Wang},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1988760},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1988760/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Case Report: Interleukin-17A blockade for SAPHO syndrome presenting as an FDG-avid destructive osteolytic acetabular lesion
AU  - Shu Liu
AU  - Anning Wang
AU  - Yiming Yuan
AU  - Xiaomin Yan
AU  - Xianfeng Yang
AU  - Qiong Jiao
AU  - Zhiyong Chen
AU  - Shiying Wang
PY  - 2026
DA  - 2026/10/23
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1988760
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1988760/full
AB  - SAPHO syndrome is an autoinflammatory osteitis disorder that may be misdiagnosed when bone destruction dominates the presentation. We report a 27-year-old woman with 7 months of left hip pain and intermittent anterior chest-wall pain. Imaging revealed an FDG-avid destructive osteolytic lesion in the left acetabulum and adjacent ilium, initially raising concern for malignancy, lymphoma, Langerhans-cell histiocytosis, or infection. Repeated tissue sampling showed chronic sterile osteomyelitis-like inflammation without evidence of malignancy or a reproducible pathogen. The disease evolved with pustular eruption after tumor necrosis factor inhibition, insufficient axial imaging control with Janus kinase inhibition, and marked improvement of a T12 vertebral-corner inflammatory lesion after interleukin-17A blockade with secukinumab. This case highlights the value of longitudinal clinicopathologic reassessment in destructive inflammatory bone disease and suggests that IL-17A blockade may be a rational strategy for SAPHO syndrome with active axial osteitis and pustular inflammation.
SN  - 1664-3224
ER  -