Detection of the PFAS ADV in a non-occupationally exposed population living in Northern Italy
7 affiliations
- 1Department of Internal Medicine and Therapeutics, University of Pavia, 27100, Italy; Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, 27100 Pavia, Italy
- 2Società Estense Servizi Ambientali (S.E.S.A. S.p.A.), 35042 Este, Italy
- 3Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100, Italy
- 4Department of Internal Medicine and Therapeutics, University of Pavia, 27100, Italy
- 5Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, 27100 Pavia, Italy
- 6Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100, Italy; Istituti Clinici Scientifici Maugeri IRCCS, Hospital Operative Occupational Medicine Unit (UOOML), 27100 Pavia, Italy
- 7Società Estense Servizi Ambientali (S.E.S.A. S.p.A.), 35042 Este, Italy; Department of Environmental Sciences, Informatic, and Statistics, Ca’ Foscari University Venice, via Torino 155, 30172 Venezia-Mestre, Italy
Abstract
Background: ADVs are substances derived from polymerized perfluoropolyether carboxylic acids (Cl-PFPECAs), produced exclusively at a fluoropolymer plant in Northern Italy. Available evidence on human exposure to ADV is limited, particularly in populations without occupational exposure and living outside the immediate vicinity of the manufacturing source. This study aimed to characterize serum ADV concentrations in a non-occupationally exposed population living in Northern Italy. Methods: A total of 150 non-occupationally exposed individuals residing and/or working in Pavia, Northern Italy, were enrolled from the IDEA study (2024–2026). Participants underwent clinical evaluation and blood sampling, and serum concentrations of six ADV isomers were measured using a validated UHPLC–MS/MS method. Associations of ADV-N2 concentrations with demographic, biochemical, and hematological parameters were investigated using multivariable regression models. Results: ADV-N2 showed the highest detection frequency (98.0% of samples above the LOD), followed by ADV-N3 and ADV-M3, whereas the other isomers were detected rarely or not detected. ADV-N2 concentrations were higher in men than in women. An age × sex interaction analysis indicated different age-related patterns of ADV-N2 concentrations in women and men, with a stronger positive age-related estimate among women. Exploratory analyses of biochemical and hematological parameters showed positive association estimates for some hepatic and lipid parameters, although estimates were attenuated after multivariable adjustment and were characterized by considerable uncertainty. Conclusions: ADV was detected in serum from individuals without occupational exposure living outside the immediate vicinity of the manufacturing source. ADV-N2 was the most frequently detected isomer and showed sex-related differences and different age-related patterns in women and men. These findings expand the available evidence on human exposure to ADV beyond occupational settings and support further investigation of its environmental distribution, exposure determinants, and potential health effects.
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BibTeX
@article{coperchini2026detection,
title = {{Detection of the PFAS ADV in a non-occupationally exposed population living in Northern Italy}},
author = {Francesca Coperchini and Laura Croce and Simone Marangoni and Francesca Sellaro and Roberta Pernetti and Alessia Greco and Elena Franchi and Marco Denegri and Enrico Oddone and Tiziano Bonato and Mario Rotondi},
journal = {Environment International},
year = {2026},
month = oct,
doi = {10.1016/j.envint.2026.110571},
url = {https://doi.org/10.1016/j.envint.2026.110571},
note = {CC BY},
}
RIS
TY - JOUR
TI - Detection of the PFAS ADV in a non-occupationally exposed population living in Northern Italy
AU - Francesca Coperchini
AU - Laura Croce
AU - Simone Marangoni
AU - Francesca Sellaro
AU - Roberta Pernetti
AU - Alessia Greco
AU - Elena Franchi
AU - Marco Denegri
AU - Enrico Oddone
AU - Tiziano Bonato
AU - Mario Rotondi
PY - 2026
DA - 2026/10/30
JO - Environment International
DO - 10.1016/j.envint.2026.110571
UR - https://doi.org/10.1016/j.envint.2026.110571
AB - Background: ADVs are substances derived from polymerized perfluoropolyether carboxylic acids (Cl-PFPECAs), produced exclusively at a fluoropolymer plant in Northern Italy. Available evidence on human exposure to ADV is limited, particularly in populations without occupational exposure and living outside the immediate vicinity of the manufacturing source. This study aimed to characterize serum ADV concentrations in a non-occupationally exposed population living in Northern Italy. Methods: A total of 150 non-occupationally exposed individuals residing and/or working in Pavia, Northern Italy, were enrolled from the IDEA study (2024–2026). Participants underwent clinical evaluation and blood sampling, and serum concentrations of six ADV isomers were measured using a validated UHPLC–MS/MS method. Associations of ADV-N2 concentrations with demographic, biochemical, and hematological parameters were investigated using multivariable regression models. Results: ADV-N2 showed the highest detection frequency (98.0% of samples above the LOD), followed by ADV-N3 and ADV-M3, whereas the other isomers were detected rarely or not detected. ADV-N2 concentrations were higher in men than in women. An age × sex interaction analysis indicated different age-related patterns of ADV-N2 concentrations in women and men, with a stronger positive age-related estimate among women. Exploratory analyses of biochemical and hematological parameters showed positive association estimates for some hepatic and lipid parameters, although estimates were attenuated after multivariable adjustment and were characterized by considerable uncertainty. Conclusions: ADV was detected in serum from individuals without occupational exposure living outside the immediate vicinity of the manufacturing source. ADV-N2 was the most frequently detected isomer and showed sex-related differences and different age-related patterns in women and men. These findings expand the available evidence on human exposure to ADV beyond occupational settings and support further investigation of its environmental distribution, exposure determinants, and potential health effects.
SN - 0160-4120
ER -