Peer-reviewedLicence not statedNew England Journal of Medicine
Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection
40 affiliations
- 1Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Guangzhou, China
- 2Division of Gastroenterology and Hepatology, National University Health System, Singapore
- 3Liver Unit, Hospital Universitario Vall d’Hebron, Centro de Investigación Biomédica en Red Enfermadades Hepáticas y Digestivas del Instituto Carlos III, Barcelona
- 4Department of Medicine, School of Clinical Medicine and State Key Laboratory of Liver Research, Queen Mary Hospital, University of Hong Kong, Hong Kong
- 5Liver Transplant Unit, University of Auckland, Auckland, New Zealand
- 6CRC A.M. and A. Migliavacca Center for Liver Disease, Department of Pathophysiology and Transplantation, University of Milan, Milan
- 7Division of Gastroenterology and Hepatology, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan
- 8Gastrointestinal and Liver Diseases Division, Keck School of Medicine, University of Southern California, Los Angeles
- 9San Jose Gastroenterology, San Jose, CA
- 10Department of Internal Medicine, Korea University Ansan Hospital, Ansan, South Korea
- 11Department of Infectious Disease, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai
- 12Department of Infectious Disease, Sichuan Provincial People’s Hospital, Chengdu, China
- 13Department of Infectious Disease, 1st Affiliated Hospital of Zhejiang University, Hangzhou, China
- 14College of Medicine, Chang Gung University, Linkou, Taiwan
- 15Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taiwan
- 16Department of Internal Medicine, College of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea
- 17Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan
- 18Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
- 19Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
- 20Department of Hepatology Division 2, Beijing Ditan Hospital, Beijing
- 21Department of Family Medicine and Infectious Diseases, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland
- 22Clinic of Internal Diseases and Hepato-Gastroenterology, University of Medicine and Hospital for Active Treatment Sofiamed, Sofia, Bulgaria
- 23Department of Gastroenterology, SIDS Hospital and Research Center, Surat, India
- 24Institute of Liver Studies, Kings College Hospital NHS Trust, London
- 25Department of Public Health, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil
- 26Hospital de Cirurgia, NewData Clinical Research, Federal University of Sergipe, Aracaju, Brazil
- 27Research Unit, Clinical Hospital for Infectious Diseases, Ovidius University of Constanta, Constanta, Romania
- 28Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand
- 29Department of Medicine, Snyder Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
- 30Liver Unit, Hospital Italiano de Buenos Aires, Buenos Aires
- 31Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell’Adulto, Università di Modena e Reggio Emilia, Modena, Italy
- 32Medicina Interna a Indirizzo Metabolico-Nutrizionale, Ospedale Clinicizzato di Baggiovara, Azienda Ospedaliaro–Universitaria di Modena, Modena, Italy
- 33Department of Gastroenterology and Hepatology, Kumamoto Shinto General Hospital, Kumamoto, Japan
- 343rd Department of Internal Medicine and Liver Unit, Evangelismos General Hospital, Athens
- 35Department of Gastroenterology and Hepatology, University of Yamanashi, Yamanashi, Japan
- 36Sorbonne Université, Hôpital Pitié–Salpêtrière, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris
- 37Centre Hospitalier Universitaire de Rouen, Hôpital Charles Nicolle, Rouen, France
- 38Department of Infectious Diseases, St. Joseph Hospital, Berlin
- 39Epimed, Berlin
- 40Aotearoa Clinical Trials, Papatoetoe, Auckland, New Zealand
Related
- 만성 B형간염에서 Bepirovirsen 3상 임상시험: 기간 한정 치료를 통한 기능적 완치의 가능성 Phase 3 Trials of Bepirovirsen in Chronic Hepatitis B: Toward Functional Cure with Finite Therapy
- Bepirovirsen improves the functional cure of chronic hepatitis B through novel mechanisms.
- Value-based price corridor for bepirovirsen in chronic hepatitis B: an early health technology assessment in a cost-compressed setting.
- Established Versus Novel Strategies for Hepatitis B Functional Cure: A Cross-Regional Cost-Effectiveness Analysis of Pegylated Interferon and Bepirovirsen Add-on Therapy
- Mass Cytometry Reveals Cell Type-specific Immune Remodeling in Placentas of Women with Chronic Hepatitis B Infection
BibTeX
@article{hou2026phase,
title = {{Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection}},
author = {Jinlin Hou and Seng Gee Lim and Marı́a Buti and M-F Yuen and Edward Gane and Pietro Lampertico and Norah A. Terrault and Huy Nguyen and Hyung Joon Yim and Qing Xie and 林健梅 and Yunqing Qiu and Wen‐Juei Jeng and Jeong Heo and Cheng‐Yuan Peng and Chien‐Hung Chen and Wan‐Long Chuang and Y D Xie and Maria Hlebowicz and Nevin Idriz and Rajiv M Mehta and Kosh Agarwal and M C Silva and Alex Franca and Roxana Carmen Cernat and Apinya Leerapun and Carla S. Coffin and Adrian Carlos Gadano and Pietro Andreoné and Shigetoshi Fujiyama and Vassilios Sevastianos and Yuichiro Suzuki and Vlad Ratziu and Ghassan Riachi and Hartmut Stocker and Tien Huey Lim and Tarik Asselah and Yasuhito Tanaka and Jacinta Holmes and Xieer Liang and Jennifer Cremer and Tamara Lukić and Helene Plein and Geoff Quinn and Yu Tao and Melanie T. Paff and Dickens Theodore and Robert Elston},
journal = {New England Journal of Medicine},
year = {2026},
month = may,
doi = {10.1056/nejmoa2515131},
url = {http://publicatio.bibl.u-szeged.hu/40536/1/Hou2026.pdf},
}
RIS
TY - JOUR
TI - Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection
AU - Jinlin Hou
AU - Seng Gee Lim
AU - Marı́a Buti
AU - M-F Yuen
AU - Edward Gane
AU - Pietro Lampertico
AU - Norah A. Terrault
AU - Huy Nguyen
AU - Hyung Joon Yim
AU - Qing Xie
AU - 林健梅
AU - Yunqing Qiu
AU - Wen‐Juei Jeng
AU - Jeong Heo
AU - Cheng‐Yuan Peng
AU - Chien‐Hung Chen
AU - Wan‐Long Chuang
AU - Y D Xie
AU - Maria Hlebowicz
AU - Nevin Idriz
AU - Rajiv M Mehta
AU - Kosh Agarwal
AU - M C Silva
AU - Alex Franca
AU - Roxana Carmen Cernat
AU - Apinya Leerapun
AU - Carla S. Coffin
AU - Adrian Carlos Gadano
AU - Pietro Andreoné
AU - Shigetoshi Fujiyama
AU - Vassilios Sevastianos
AU - Yuichiro Suzuki
AU - Vlad Ratziu
AU - Ghassan Riachi
AU - Hartmut Stocker
AU - Tien Huey Lim
AU - Tarik Asselah
AU - Yasuhito Tanaka
AU - Jacinta Holmes
AU - Xieer Liang
AU - Jennifer Cremer
AU - Tamara Lukić
AU - Helene Plein
AU - Geoff Quinn
AU - Yu Tao
AU - Melanie T. Paff
AU - Dickens Theodore
AU - Robert Elston
PY - 2026
DA - 2026/05/28
JO - New England Journal of Medicine
DO - 10.1056/nejmoa2515131
UR - http://publicatio.bibl.u-szeged.hu/40536/1/Hou2026.pdf
SN - 0028-4793
SN - 0096-6762
SN - 1533-4406
SN - 2331-4710
ER -