Biogenic aluminium nanoparticles synthesized from Terminalia chebula seed extract: characterization and exploration of their antiproliferative, antimicrobial and biosensing potential

@article{ramalingam2026biogenic,
  title = {{Biogenic aluminium nanoparticles synthesized from Terminalia chebula seed extract: characterization and exploration of their antiproliferative, antimicrobial and biosensing potential}},
  author = {Shenbhagaraman Ramalingam and Jenefar Sudarson and Archana Behera and Mukesh Kumar Dharmalingam Jothinathan and Mythileeswari Lakshmikanthan and Sakthivel Muthu and Maryam Abbasi Tarighat and Gholamreza Abdi},
  journal = {Scientific Reports},
  year = {2026},
  month = jul,
  doi = {10.1038/s41598-026-63168-w},
  url = {https://doi.org/10.1038/s41598-026-63168-w},
  note = {CC BY},
}

TY  - JOUR
TI  - Biogenic aluminium nanoparticles synthesized from Terminalia chebula seed extract: characterization and exploration of their antiproliferative, antimicrobial and biosensing potential
AU  - Shenbhagaraman Ramalingam
AU  - Jenefar Sudarson
AU  - Archana Behera
AU  - Mukesh Kumar Dharmalingam Jothinathan
AU  - Mythileeswari Lakshmikanthan
AU  - Sakthivel Muthu
AU  - Maryam Abbasi Tarighat
AU  - Gholamreza Abdi
PY  - 2026
DA  - 2026/07/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-63168-w
UR  - https://doi.org/10.1038/s41598-026-63168-w
AB  - The green synthesis of aluminium nanoparticles (Al-NPs) via aqueous extract of Terminalia chebula was used to evaluate the structural, biological and sensing applications of the synthesized nanoparticles. Nanoparticle development was confirmed by UV–Visible spectroscopy, showing a typical absorption peak at 300 nm. Fourier transform infrared spectroscopy (FTIR) identified key biomolecules involved in reduction and stabilization, including polysaccharides (C–O–C at 1044 cm− 1), proteins/peptides (amide I band at 1660 cm− 1) and phenolic compounds (O–H bending at 1328 cm− 1), with additional bands indicating the presence of alkenes and aromatic groups. Scanning electron microscopy (SEM) revealed irregular, spherical, leaf-like aggregates measuring 30 to 80 nm, while Energy Dispersive X-ray spectroscopy (EDX) established elemental proportion consistent with aluminium oxide, with Carbon, oxygen and aluminium present at 51.9%, 23.9% and 24.5% by weight, respectively. The biological activity of Al-NPs was demonstrated through dose-dependent antiproliferative effects against A549 lung carcinoma cells with an IC₅₀ value of 72.04 µg/mL, assessed via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Biogenic Al-NPs treated cells demonstrated orange-to-red fluorescence, indicates the presence of condensed and fragmented nuclei using Acridine Orange and Ethidium Bromide (AO/EB) assay, indicating apoptosis. The antibacterial efficacy of the biogenic Al-NPs was evaluated using Resazurin Based Microplate assay. The nanoparticles exhibited minimum inhibitory concentration (MIC) values of 1250, 625, 312, and 312 µg/mL and minimum bactericidal concentration (MBC) values of 2500, 1250, 312, and 625 µg/mL against Staphylococcus aureus, Salmonella ebony, Escherichia coli, and Pseudomonas aeruginosa, respectively, demonstrating enhanced activity against Gram-negative bacteria. Furthermore, the Al-NPs exhibited sensitive optical glucose sensing, with UV–Visible spectra showing a linear decrease in plasmonic absorption at 300 nm over glucose concentrations of 1–22 mM. These results highlight the potential of T. chebula mediated Al-NPs as multifunctional nanomaterials for biomedical and biosensing applications.
SN  - 2045-2322
ER  -