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Peer-reviewedCC BY-NC 4.0Cancer Control: Journal of the Moffitt Cancer Center

Making PRO Data Work: Remote Monitoring, Real-Time Visualization, and Timely Intervention in Oncology Trials and Patient Care

  • Bill Byrom1
  • Anthony Everhart2
  1. 1eCOA Science, Signant Health, Blue Bell, PA, USA
  2. 2Science and Medicine Signant Health, Blue Bell, PA, USA
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Abstract

Clinician assessment of adverse events in oncology systematically underestimates the severity and frequency of symptoms that patients actually experience, creating risks in both drug development and routine care. Electronic patient-reported outcome (ePRO) systems help to address this gap by enabling frequent remote symptom monitoring, bringing the patient voice into the care pathway between clinic visits. Published studies confirm that automated data-driven alerting in response to ePRO data entries can drive better patient outcomes including reduced emergency department visits, delayed physical function deterioration, and improved symptom control, with early intervention the likely mechanism. Translating this evidence into practice demands deliberate attention to how data are visualized, communicated, and acted upon. This perspectives article examines, primarily in the context of oncology clinical trials, the tools and design principles that translate ePRO data into timely clinical action, including heatmap visualizations that reveal symptom trajectories at a glance, predefined alert thresholds that trigger proactive responses, and patient-facing self-management support delivered at the moment of reporting. The regulatory, ethical and methodological case for embedding active monitoring within oncology trial design is also considered.

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Cite

BibTeXRIS
BibTeX
@article{byrom2026making,
  title = {{Making PRO Data Work: Remote Monitoring, Real-Time Visualization, and Timely Intervention in Oncology Trials and Patient Care}},
  author = {Bill Byrom and Anthony Everhart},
  journal = {Cancer Control: Journal of the Moffitt Cancer Center},
  year = {2026},
  month = sep,
  doi = {10.1177/10732748261492633},
  url = {https://doi.org/10.1177/10732748261492633},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Making PRO Data Work: Remote Monitoring, Real-Time Visualization, and Timely Intervention in Oncology Trials and Patient Care
AU  - Bill Byrom
AU  - Anthony Everhart
PY  - 2026
DA  - 2026/09/22
JO  - Cancer Control: Journal of the Moffitt Cancer Center
DO  - 10.1177/10732748261492633
UR  - https://doi.org/10.1177/10732748261492633
AB  - Clinician assessment of adverse events in oncology systematically underestimates the severity and frequency of symptoms that patients actually experience, creating risks in both drug development and routine care. Electronic patient-reported outcome (ePRO) systems help to address this gap by enabling frequent remote symptom monitoring, bringing the patient voice into the care pathway between clinic visits. Published studies confirm that automated data-driven alerting in response to ePRO data entries can drive better patient outcomes including reduced emergency department visits, delayed physical function deterioration, and improved symptom control, with early intervention the likely mechanism. Translating this evidence into practice demands deliberate attention to how data are visualized, communicated, and acted upon. This perspectives article examines, primarily in the context of oncology clinical trials, the tools and design principles that translate ePRO data into timely clinical action, including heatmap visualizations that reveal symptom trajectories at a glance, predefined alert thresholds that trigger proactive responses, and patient-facing self-management support delivered at the moment of reporting. The regulatory, ethical and methodological case for embedding active monitoring within oncology trial design is also considered.
SN  - 1073-2748
SN  - 1526-2359
ER  -