Enhancing canine intestinal health: evodiamine-enriched functional diet modulates microbiota and metabolic pathways.
4 affiliations
- 1Institute of Innovation and Translational Medicine, Gannan Medical University, Ganzhou, China.
- 2Gannan Institute of Innovation and Translational Medicine, Ganzhou, China.
- 3State Key Laboratory of New Targets Discovery and Drug Development for Major Disease, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
- 4Ganzhou Pet Health Science Research Institute, Ganzhou, China.
Abstract
This study investigated the effects of an evodiamine (EVO)-enriched functional diet on canine intestinal health, with a focus on its modulation of microbiota composition and promotion of intestinal well-being. After a one-week acclimatization period, dogs were randomly assigned to either the control group or the EVO group, receiving their respective diets for 8 weeks. Physiological and hematological parameters were assessed at 0, 4, and 8 weeks, and fresh feces were collected at 4 and 8 weeks for microbial analysis to evaluate the impact of the functional diet on canine intestinal microorganisms. The 8-week trial revealed that the functional gut diet regulated microbial composition, improving intestinal health without affecting body metrics or routine blood indicators, and the diet's safety was affirmed by normal biochemical indices. Comparative analysis indicated altered microbial abundance in model dogs, highlighting positive changes favoring intestinal barrier enhancement. Alpha diversity analysis confirmed increased species diversity in the EVO group, reflecting a healthier gut. Moreover, the study demonstrated the functional diet's regulatory impact on microbial metabolic pathways and species differences without observed side effects, reinforcing its positive influence on gut health. Therefore, the canine intestinal functional diet containing EVO showed no significant impact on physiological health but exhibited regulatory effects on intestinal microorganisms. EVO effectively modulated microbial abundance and diversity, fostering intestinal mucosal repair and barrier protection. Additionally, the diet improved microbial function by regulating canine intestinal metabolic pathways. This study serves as a valuable reference for future research in promoting canine intestinal health.
Related
- Zhuhuang Granules alleviate psoriatic inflammation via restoring gut microbiota balance and enhancing intestinal barrier integrity.
- Dietary BmKn2-7 Supplementation Modulates Intestinal Microbiota and Hepatopancreatic Responses and Enhances Resistance to Vibrio parahaemolyticus in Litopenaeus vannamei
- Microbiota-driven, strain-specific Asaia colonisation modulates mosquito vector competence
- Chronic {triangleup}9-Tetrahydrocannabinol Vapor Self-Administration Modulates Gut Microbiota and the Immune and Endocannabinoid Systems in Female Sprague-Dawley Rats
- Intestinal microbiota-associated LysoPC(16:0) promotes endometriosis via PPARγ-mediated M2 macrophage polarization and IL-10 secretion
BibTeX
@article{wang2026enhancing,
title = {{Enhancing canine intestinal health: evodiamine-enriched functional diet modulates microbiota and metabolic pathways.}},
author = {Qingzheng Wang and Fuqing Huang and Xu Cheng and Song Tian and Juan Wan and Yun Chen and Xiaojie Xiao and Xin Zhang and Manli Hu},
journal = {Journal of animal science and technology},
year = {2026},
month = sep,
doi = {10.5187/jast.2024.e89},
url = {https://europepmc.org/article/MED/42898839},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Enhancing canine intestinal health: evodiamine-enriched functional diet modulates microbiota and metabolic pathways.
AU - Qingzheng Wang
AU - Fuqing Huang
AU - Xu Cheng
AU - Song Tian
AU - Juan Wan
AU - Yun Chen
AU - Xiaojie Xiao
AU - Xin Zhang
AU - Manli Hu
PY - 2026
DA - 2026/09/30
JO - Journal of animal science and technology
DO - 10.5187/jast.2024.e89
UR - https://europepmc.org/article/MED/42898839
AB - This study investigated the effects of an evodiamine (EVO)-enriched functional diet on canine intestinal health, with a focus on its modulation of microbiota composition and promotion of intestinal well-being. After a one-week acclimatization period, dogs were randomly assigned to either the control group or the EVO group, receiving their respective diets for 8 weeks. Physiological and hematological parameters were assessed at 0, 4, and 8 weeks, and fresh feces were collected at 4 and 8 weeks for microbial analysis to evaluate the impact of the functional diet on canine intestinal microorganisms. The 8-week trial revealed that the functional gut diet regulated microbial composition, improving intestinal health without affecting body metrics or routine blood indicators, and the diet's safety was affirmed by normal biochemical indices. Comparative analysis indicated altered microbial abundance in model dogs, highlighting positive changes favoring intestinal barrier enhancement. Alpha diversity analysis confirmed increased species diversity in the EVO group, reflecting a healthier gut. Moreover, the study demonstrated the functional diet's regulatory impact on microbial metabolic pathways and species differences without observed side effects, reinforcing its positive influence on gut health. Therefore, the canine intestinal functional diet containing EVO showed no significant impact on physiological health but exhibited regulatory effects on intestinal microorganisms. EVO effectively modulated microbial abundance and diversity, fostering intestinal mucosal repair and barrier protection. Additionally, the diet improved microbial function by regulating canine intestinal metabolic pathways. This study serves as a valuable reference for future research in promoting canine intestinal health.
SN - 2055-0391
ER -