Enhanced antibacterial activities of zirconia nanoparticles modified with yttrium oxide and alumina
8 affiliations
- 1College of Applied Sciences, University of Technology, Baghdad, 10066, Iraq
- 2College of Pharmacy, Al-Turath University Baghdad, Baghdad, Iraq
- 3Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq
- 4Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, 252059, China
- 5College of Applied Sciences, University of Technology, Baghdad, 10066, Iraq. [email protected]
- 6Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, 11451, Saudi Arabia
- 7Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia
- 8Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, 11451, Saudi Arabia. [email protected]
Abstract
Antibacterial activities of ZrO2, binary mixture (ZrO2+ Y2O3),and triple mixture (ZrO2 + Y2O3 + Al2O3) were studied against pathogenic bacterial strains, Escherichia coli and Staphylococcus aureus. The study also revealed the bacterial biofilm inhibition and biocompatibility of ZrO2 + Y2O3 + Al2O3. The triple mixture, composed of zirconium dioxide, yttrium trioxide, and aluminum trioxide (ZrO2 + Y2O3 + Al2O3), exhibited highest anti-bacterial effects against Staphylococcus aureus as compared with the Escherichia coli, with inhibition zone diameters of 27.33 mm and 22.66 mm, respectively. The binary mixture (ZrO2 + Y2O3) was comparable with the triple mixture in their antibacterial effects with the inhibition zone diameters of 24.66 mm and 21 mm as against Staphylococcus aureus, and Escherichia coli, respectively. Finally, the ZrO2 alone showed the lowest antibacterial effects. Furthermore, after 24 h of incubation at 37 °C, the three composites were also evaluated for the potential anti-adherence for the microbial biofilm in Streptococcus mutans. The results showed the adhesion process was decreased with increasing the concentrations of the triple mixture. Moreover, the in vitro biocompatibility evaluations in Rat Embryonic Fibroblast (REF) cells showed that the nanoparticles possessed low cytotoxicity, and indicated good biocompatibility. Hence, it was inferred that the synthesized Zirconia–Yttria triple mixture system can be useful for biomedical applications, especially in the field of dental implant techniques.
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BibTeX
@article{saad2026enhanced,
title = {{Enhanced antibacterial activities of zirconia nanoparticles modified with yttrium oxide and alumina}},
author = {Sally Mazin Saad and Enas Muhi Hadi and Nehia Neama Hussein and Haydar M. Al-kuraishy and Muhammad Faheem Akhtar and Majid S. Jabir and Hani A. Ba-Awadh and Alaa Bassuny Ismael and Ayman A. Swelum},
journal = {Scientific Reports},
year = {2026},
month = may,
doi = {10.1038/s41598-025-29085-0},
url = {https://doi.org/10.1038/s41598-025-29085-0},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Enhanced antibacterial activities of zirconia nanoparticles modified with yttrium oxide and alumina
AU - Sally Mazin Saad
AU - Enas Muhi Hadi
AU - Nehia Neama Hussein
AU - Haydar M. Al-kuraishy
AU - Muhammad Faheem Akhtar
AU - Majid S. Jabir
AU - Hani A. Ba-Awadh
AU - Alaa Bassuny Ismael
AU - Ayman A. Swelum
PY - 2026
DA - 2026/05/11
JO - Scientific Reports
DO - 10.1038/s41598-025-29085-0
UR - https://doi.org/10.1038/s41598-025-29085-0
AB - Antibacterial activities of ZrO2, binary mixture (ZrO2+ Y2O3),and triple mixture (ZrO2 + Y2O3 + Al2O3) were studied against pathogenic bacterial strains, Escherichia coli and Staphylococcus aureus. The study also revealed the bacterial biofilm inhibition and biocompatibility of ZrO2 + Y2O3 + Al2O3. The triple mixture, composed of zirconium dioxide, yttrium trioxide, and aluminum trioxide (ZrO2 + Y2O3 + Al2O3), exhibited highest anti-bacterial effects against Staphylococcus aureus as compared with the Escherichia coli, with inhibition zone diameters of 27.33 mm and 22.66 mm, respectively. The binary mixture (ZrO2 + Y2O3) was comparable with the triple mixture in their antibacterial effects with the inhibition zone diameters of 24.66 mm and 21 mm as against Staphylococcus aureus, and Escherichia coli, respectively. Finally, the ZrO2 alone showed the lowest antibacterial effects. Furthermore, after 24 h of incubation at 37 °C, the three composites were also evaluated for the potential anti-adherence for the microbial biofilm in Streptococcus mutans. The results showed the adhesion process was decreased with increasing the concentrations of the triple mixture. Moreover, the in vitro biocompatibility evaluations in Rat Embryonic Fibroblast (REF) cells showed that the nanoparticles possessed low cytotoxicity, and indicated good biocompatibility. Hence, it was inferred that the synthesized Zirconia–Yttria triple mixture system can be useful for biomedical applications, especially in the field of dental implant techniques.
SN - 2045-2322
ER -