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Peer-reviewedCC BYOrganic letters

A Modular Rapid-Injection NMR for Structure Elucidation and Kinetic Analysis.

  • Andrew J Ressler1
  • Han-Hsiang Hsu1
  • Andy A Thomas1
  1. 1Department of Chemistry, Texas A&M University, College Station, Texas77843-3255, United States.
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Abstract

Rapid-injection nuclear magnetic resonance (RI-NMR) spectroscopy transforms a standard NMR tube into a reaction vessel within the NMR spectrometer, enabling kinetic and spectroscopic characterization of intermediates under synthetically relevant conditions. Despite its versatility as a tool for mechanistic analysis, the broad adoption of RI-NMR has been hindered by the lack of cost- and space-efficient instrument designs, which can be operated with negligible interference to the NMR facility. Herein, we describe an RI apparatus that is compatible with most NMR spectrometers, requires no modification of the NMR instrument or probe, and may be easily transported to and from the laboratory. Accurate reagent delivery is achieved across a range of solvents and temperatures, and samples can be mixed within seconds after injection. The utility of this apparatus is highlighted through four case studies chosen to illustrate different aspects of the instrument.

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Cite

BibTeXRIS
BibTeX
@article{ressler2026modular,
  title = {{A Modular Rapid-Injection NMR for Structure Elucidation and Kinetic Analysis.}},
  author = {Andrew J Ressler and Han-Hsiang Hsu and Andy A Thomas},
  journal = {Organic letters},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.orglett.6c02870},
  url = {https://europepmc.org/article/MED/42917793},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - A Modular Rapid-Injection NMR for Structure Elucidation and Kinetic Analysis.
AU  - Andrew J Ressler
AU  - Han-Hsiang Hsu
AU  - Andy A Thomas
PY  - 2026
DA  - 2026/10/01
JO  - Organic letters
DO  - 10.1021/acs.orglett.6c02870
UR  - https://europepmc.org/article/MED/42917793
AB  - Rapid-injection nuclear magnetic resonance (RI-NMR) spectroscopy transforms a standard NMR tube into a reaction vessel within the NMR spectrometer, enabling kinetic and spectroscopic characterization of intermediates under synthetically relevant conditions. Despite its versatility as a tool for mechanistic analysis, the broad adoption of RI-NMR has been hindered by the lack of cost- and space-efficient instrument designs, which can be operated with negligible interference to the NMR facility. Herein, we describe an RI apparatus that is compatible with most NMR spectrometers, requires no modification of the NMR instrument or probe, and may be easily transported to and from the laboratory. Accurate reagent delivery is achieved across a range of solvents and temperatures, and samples can be mixed within seconds after injection. The utility of this apparatus is highlighted through four case studies chosen to illustrate different aspects of the instrument.
SN  - 1523-7060
SN  - 1523-7052
ER  -