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Peer-reviewedCC BY 4.0PLOS Biology

Cellular diversity in neural organoids is critical for neurodegenerative disease modeling

  • Shiying Liu1
  • Shi-Yan Ng1,2
  1. 1Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
  2. 2Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
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Abstract

Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. For organoids intended to model neurodegeneration, immune, and vascular cells should therefore be considered fundamental components, rather than optional additions.

Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. This Perspective argues that immune and vascular cells need to be fundamental components of organoids intended to model neurodegeneration, rather than optional extras.

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Cite

BibTeXRIS
BibTeX
@article{liu2026cellular,
  title = {{Cellular diversity in neural organoids is critical for neurodegenerative disease modeling}},
  author = {Shiying Liu and Shi-Yan Ng},
  journal = {PLOS Biology},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pbio.3004074},
  url = {https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004074},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Cellular diversity in neural organoids is critical for neurodegenerative disease modeling
AU  - Shiying Liu
AU  - Shi-Yan Ng
PY  - 2026
DA  - 2026/10/14
JO  - PLOS Biology
DO  - 10.1371/journal.pbio.3004074
UR  - https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004074
AB  - Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. For organoids intended to model neurodegeneration, immune, and vascular cells should therefore be considered fundamental components, rather than optional additions.  Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. This Perspective argues that immune and vascular cells need to be fundamental components of organoids intended to model neurodegeneration, rather than optional extras.
SN  - 1545-7885
SN  - 1544-9173
ER  -