Crosstalk between chemotherapeutics and tumor-associated macrophages (TAMs): implications for tumor response.
- 1Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza 11/12, 80-233, Gdańsk, Poland.
- 2Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1a, 02- 097, Warsaw, Poland.
- 3Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza 11/12, 80-233, Gdańsk, Poland. [email protected].
Abstract
The understanding of cancer has evolved from a group of mutated cancerous cells to a complex ecosystem comprising many cellular and non-cellular components. Tumor-associated macrophages (TAMs) are one of the most abundant immune cells in the tumor microenvironment (TME). They actively contribute to cancer outcomes in two ways, either promoting its development and progression or stimulating immune response to combat tumor. Recently, TAMs have been recognized not only as prognostic markers for the outcome of anti-cancer therapy, but also as major players in shaping treatment response. It was also established that therapeutic agents may affect TAMs' phenotype, and in consequence modulate tumor's behavior. Therefore, reprogramming of TAMs in order to enhance tumor infiltration and overcome immune suppression is also currently a hot topic in preclinical research. In this review, we discuss the interactions between chemotherapeutic agents and tumor-associated macrophages and their potential consequences for tumor response.
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BibTeX
@article{pezala2026crosstalk,
title = {{Crosstalk between chemotherapeutics and tumor-associated macrophages (TAMs): implications for tumor response.}},
author = {Bożena Pezała and Magdalena Radziszewska and Ewa Augustin},
journal = {Journal of cancer research and clinical oncology},
year = {2026},
month = aug,
doi = {10.1007/s00432-026-06575-w},
url = {https://europepmc.org/article/MED/42967962},
note = {CC BY},
}
RIS
TY - JOUR
TI - Crosstalk between chemotherapeutics and tumor-associated macrophages (TAMs): implications for tumor response.
AU - Bożena Pezała
AU - Magdalena Radziszewska
AU - Ewa Augustin
PY - 2026
DA - 2026/08/04
JO - Journal of cancer research and clinical oncology
DO - 10.1007/s00432-026-06575-w
UR - https://europepmc.org/article/MED/42967962
AB - The understanding of cancer has evolved from a group of mutated cancerous cells to a complex ecosystem comprising many cellular and non-cellular components. Tumor-associated macrophages (TAMs) are one of the most abundant immune cells in the tumor microenvironment (TME). They actively contribute to cancer outcomes in two ways, either promoting its development and progression or stimulating immune response to combat tumor. Recently, TAMs have been recognized not only as prognostic markers for the outcome of anti-cancer therapy, but also as major players in shaping treatment response. It was also established that therapeutic agents may affect TAMs' phenotype, and in consequence modulate tumor's behavior. Therefore, reprogramming of TAMs in order to enhance tumor infiltration and overcome immune suppression is also currently a hot topic in preclinical research. In this review, we discuss the interactions between chemotherapeutic agents and tumor-associated macrophages and their potential consequences for tumor response.
SN - 0171-5216
SN - 1432-1335
ER -